protein

EIF2Α

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

198Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

Page for EIF2α Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	EIF2Α
Molecular Weight	36.1 kDa
Pathways	Unfolded Protein Response
Interactions	ABCA7, ABCD3, ALZHEIMER, AMBRA1, AMPK, ATF4
KG Connections	196 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    EIF2_["EIF2Alpha"]
    GENES["GENES"]
    EIF2_ -->|"co discussed"| GENES
    RNA["RNA"]
    EIF2_ -->|"regulates"| RNA
    DRP1["DRP1"]
    EIF2_ -->|"activates"| DRP1
    BNIP3L["BNIP3L"]
    EIF2_ -->|"activates"| BNIP3L
    OPTINEURIN["OPTINEURIN"]
    EIF2_ -->|"activates"| OPTINEURIN
    PRESENILIN["PRESENILIN"]
    EIF2_ -->|"activates"| PRESENILIN
    MIRO1["MIRO1"]
    EIF2_ -->|"activates"| MIRO1
    UBIQUITIN["UBIQUITIN"]
    EIF2_ -->|"activates"| UBIQUITIN
    CATALASE["CATALASE"]
    EIF2_ -->|"activates"| CATALASE
    NLRP3["NLRP3"]
    EIF2_ -->|"activates"| NLRP3
    PARL["PARL"]
    EIF2_ -->|"activates"| PARL
    LC3B["LC3B"]
    EIF2_ -->|"activates"| LC3B
    DNM1L["DNM1L"]
    EIF2_ -->|"activates"| DNM1L
    BCL2L11["BCL2L11"]
    EIF2_ -->|"activates"| BCL2L11
    MFN1["MFN1"]
    EIF2_ -->|"activates"| MFN1
    LGALS3["LGALS3"]
    EIF2_ -->|"activates"| LGALS3
    ALZHEIMER["ALZHEIMER"]
    EIF2_ -->|"activates"| ALZHEIMER
    PARKINSON["PARKINSON"]
    EIF2_ -->|"activates"| PARKINSON
    apoptosis["apoptosis"]
    EIF2_ -->|"activates"| apoptosis
    DEMENTIA["DEMENTIA"]
    EIF2_ -->|"activates"| DEMENTIA
    AMPK["AMPK"]
    EIF2_ -->|"activates"| AMPK
    CELL_CYCLE["CELL CYCLE"]
    EIF2_ -->|"activates"| CELL_CYCLE
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    EIF2_ -->|"activates"| FRONTOTEMPORAL_DEMENTIA
    Alzheimer_Disease["Alzheimer Disease"]
    EIF2_ -->|"activates"| Alzheimer_Disease
    HIF1["HIF1"]
    EIF2_ -->|"activates"| HIF1
    EIF2S1["EIF2S1"]
    EIF2_ -->|"activates"| EIF2S1
    PGAM5["PGAM5"]
    EIF2_ -->|"activates"| PGAM5
    RIP3["RIP3"]
    EIF2_ -->|"activates"| RIP3
    RETREG1["RETREG1"]
    EIF2_ -->|"activates"| RETREG1
    disease["disease"]
    EIF2_ -->|"activates"| disease

Outgoing (103)

Target	Relation	Type	Str
GENES	co_discussed	gene	0.50
RNA	regulates	gene	0.50
MFN1	activates	gene	0.50
LGALS3	activates	gene	0.50
ALZHEIMER	activates	gene	0.50
PARKINSON	activates	gene	0.50
apoptosis	activates	process	0.50
DEMENTIA	activates	gene	0.50
AMPK	activates	protein	0.50
CELL CYCLE	activates	cell_type	0.50
FRONTOTEMPORAL DEMENTIA	activates	disease	0.50
Alzheimer Disease	activates	disease	0.50
HIF1	activates	concept	0.50
EIF2S1	activates	concept	0.50
PGAM5	activates	concept	0.50
RIP3	activates	concept	0.50
RETREG1	activates	concept	0.50
disease	activates	disease	0.50
ENDOTHELIAL	activates	concept	0.50
FRONTOTEMPORAL	activates	concept	0.50
COPD	activates	disease	0.50
SYNUCLEIN	activates	concept	0.50
Reactive Oxygen Species	activates	process	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
IRE1	activates	protein	0.50
Proteins	activates	protein	0.50
GABARAP	activates	protein	0.50
TIA1	activates	protein	0.50
SARS	activates	gene	0.50
LYSOSOME	activates	gene	0.50
ATG8	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
DRP1	activates	protein	0.50
Astrocytes	activates	cell_type	0.50
Unfolded Protein Response	activates	pathway	0.50
Astrocyte	activates	cell_type	0.50
BNIP3L	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
PRESENILIN	activates	protein	0.50
MIRO1	activates	protein	0.50
UBIQUITIN	activates	protein	0.50
CATALASE	activates	protein	0.50
NLRP3	activates	protein	0.50
PARL	activates	protein	0.50
LC3B	activates	protein	0.50
DNM1L	activates	gene	0.50
BCL2L11	activates	gene	0.50
NEURONS	activates	concept	0.50
ENDOPLASMIC RETICULUM STRESS	activates	concept	0.50

Incoming (95)

Source	Relation	Type	Str
Dolutegravir	activates	drug	0.80
EEF2	phosphorylates	gene	0.80
HSPA5	activates	gene	0.50
XBP1	activates	gene	0.50
PPP1R15A	activates	gene	0.50
ATF4	activates	protein	0.50
GABA	activates	gene	0.50
mTOR	activates	entity	0.50
EIF2A	activates	protein	0.50
PEX3	activates	gene	0.50
RB1CC1	activates	gene	0.50
RTN3	activates	gene	0.50
MUL1	activates	gene	0.50
CHOP	activates	gene	0.50
BCL2	activates	gene	0.50
EPAS1	activates	gene	0.50
CALCOCO2	activates	gene	0.50
SNCAIP	activates	gene	0.50
NBR1	activates	gene	0.50
AMBRA1	activates	protein	0.50
PERK	activates	gene	0.50
HIF1A	activates	gene	0.50
ABCD3	activates	gene	0.50
Autophagy	activates	process	0.50
MITOCHONDRIA	activates	cell_type	0.50
SNCA	activates	gene	0.50
STING1	activates	protein	0.50
G3BP1	activates	gene	0.50
EIF2AK3	activates	gene	0.50
DDIT3	activates	gene	0.50
CTSD	activates	gene	0.50
MAPK8	activates	gene	0.50
RIPK3	activates	gene	0.50
OPTN	activates	gene	0.50
PARKIN	activates	gene	0.50
LMNA	activates	gene	0.50
NDP52	activates	gene	0.50
PTEN	activates	gene	0.50
FIP200	activates	gene	0.50
BECN1	activates	gene	0.50
FAM134B	activates	gene	0.50
PINK1	activates	gene	0.50
ERN1	activates	gene	0.50
CANX	activates	gene	0.50
BNIP3	activates	gene	0.50
SQSTM1	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
SESN2	activates	gene	0.50
DISC1	activates	gene	0.50
PRKN	activates	gene	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2α Phosphorylation Imbalance Creates Integrated Stress Re	0.866	ALS	-
H6: Aberrant eIF2α Phosphorylation Creates Stalled Translati	0.856	neurodegeneration	How do pathological stress granules tran
eIF2α Phosphorylation Imbalance Disrupts Mitochondrial Prote	0.000	ALS	-
TBK1 Loss Triggers eIF2α-Mediated Translational Repression T	0.000	ALS	What are the mechanisms by which microgl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PERK Inhibitor GSK2606414 + GADD34 Mimetic Sephin1 Rescues eIF2alpha S	in_vitro	ALS / FTD	0.830	0.85	iPSC-derived motor neurons fro	proposed	$67,000

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Calcium release from damaged lysosomes triggers stress granule formation for cel [PMID:39962896]	Jayabalan AK, Ayeni A, Jia J	Autophagy	2025
Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzb [PMID:41453885]	Chen Y, Kunjamma RB, Lin K	Nat Commun	2025
Oligodendrocyte-selective deletion of the eIF2α kinase Perk/Eif2ak3 limits funct [PMID:38587137]	Saraswat Ohri S, Forston MD, Myers SA	Glia	2024
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and [PMID:31204559]	["Wan Huida", "Wang Qi", "Chen Xiuting",	Autophagy	2020
Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrate [PMID:32086012]	Horn M, Denzel SI, Srinivasan B	iScience	2020
Quercetin Regulates the Integrated Stress Response to Improve Memory. [PMID:31195662]	Nakagawa T, Ohta K	Int J Mol Sci	2019
The UPR and synaptic dysfunction in neurodegeneration. [PMID:27021956]	Freeman OJ, Mallucci GR	Brain Res	2016

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF2Α in their description or question text

No additional research found