gene

MAPK8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

637Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAPK8 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ALI, ALS. Connected to 283 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK8
Full Name	Mitogen-Activated Protein Kinase 8
Chromosome	10q11.22.
Protein Family	MAPK (Mitogen-Activated Protein Kinases)
Protein Type	Serine/Threonine Kinase
Function	- Transcription factors: c-Jun, JunB, JunD, ATF2, ELK-1
Molecular Weight	46 kDa
Amino Acids	427 aa
Pathways	MAPK, NF-κB
UniProt ID	P45985
NCBI Gene ID	5599
Ensembl ID	ENSG00000106789
GeneCards	MAPK8
Human Protein Atlas	MAPK8
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Polyphenols, rapamycin
Interactions	ABCD3, AKT1, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	637 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAPK8 — AlphaFold P45985 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK8["MAPK8"] -->|"Interacts With"| Dementia["Dementia"]
    MAPK8["MAPK8"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    MAPK8["MAPK8"] -->|"Interacts With"| Als["Als"]
    MAPK8["MAPK8"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    MAPK8["MAPK8"] -->|"Interacts With"| Parkinson["Parkinson"]
    MAPK8["MAPK8"] -->|"Interacts With"| Ms["Ms"]
    MAPK8["MAPK8"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MAPK8["MAPK8"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| MAPK8["MAPK8"]
    OPTN["OPTN"] -->|"Interacts With"| MAPK8["MAPK8"]
    DNM1L["DNM1L"] -->|"Interacts With"| MAPK8["MAPK8"]
    CANX["CANX"] -->|"Interacts With"| MAPK8["MAPK8"]
    LGALS3["LGALS3"] -->|"Interacts With"| MAPK8["MAPK8"]
    style MAPK8 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (362)

Target	Relation	Type	Str
Neurodegeneration	involved_in	process	0.90
ER Stress Response	mediates	process	0.85
Endoplasmic Reticulum Stress Response	mediates	process	0.85
Apoptosis	upregulates	process	0.85
PARP1	phosphorylates	protein	0.85
ANTI-APOPTOTIC PROTEINS	downregulates	protein	0.85
Inflammation	mediates	process	0.75
Parkinson	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Osteoarthritis	implicated_in	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Rheumatoid Arthritis	implicated_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Osteoporosis	implicated_in	disease	0.65
Ms	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Ftd	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Longevity	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Oxidative Stress	associated_with	pathway	0.60
Phagocytosis	associated_with	pathway	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60

Incoming (275)

Source	Relation	Type	Str
Ros	activates	process	0.90
Cholix	upregulates	entity	0.85
KDEL	activates	receptor	0.85
Scutellarein	downregulates	compound	0.80
Polyphenols	inhibits	compound	0.80
CASP3	interacts_with	gene	0.70
MIRNAS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
GFP	activates	gene	0.60
GLUT4	activates	gene	0.60
rapamycin	targets	drug	0.60
JNK	activates	entity	0.60
AGING	associated_with	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
GBA	activates	entity	0.60
HIF1A	activates	entity	0.60
MIRNAS	expressed_in	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK8 in their description or question text

No additional research found