protein

BNIP3L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BNIP3L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1019Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

BNIP3L is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 517 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BNIP3L
Full Name	BCL2 Interacting Protein 3 Like (NIX)
Chromosome	8p21.2
Function	Mitochondrial recruitment: Being anchored to the mitochondrial outer membrane, BNIP3L clusters at sites of autophagosome initiation
Primary Expression	Cerebral cortex, Mitochondria, Substantia nigra
Pathways	Adaptive Immunity, Apoptosis, Autophagy, Epigenetic, Immune Response
UniProt ID	O60238
NCBI Gene ID	665
OMIM	603588
GeneCards	BNIP3L
Human Protein Atlas	BNIP3L
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Interactions	ABCD3, ADORA2A, AGING, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	1016 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BNIP3L — AlphaFold O60238 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

gene · 738 words

→

BNIP3L Protein

protein · 711 words

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Pathway Diagram

flowchart TD
    BNIP3L(["BNIP3L"])
    Mitophagy["Mitophagy"]
    MITOPHAGY_RECEPTOR["MITOPHAGY RECEPTOR"]
    PROTEASOMES["PROTEASOMES"]
    mitophagy["mitophagy"]
    Damaged_Mitochondria("Damaged Mitochondria")
    Als["Als"]
    Proteasome["Proteasome"]
    Mitochondrial_Damage("Mitochondrial Damage")
    Autophagy["Autophagy"]
    MITOPHAGY(["MITOPHAGY"])
    NIX(["NIX"])
    Cancer["Cancer"]

    BNIP3L -->|"involved in"| Mitophagy
    BNIP3L -->|"associated with"| MITOPHAGY_RECEPTOR
    PROTEASOMES -.->|"degrades"| BNIP3L
    BNIP3L -->|"participates in"| mitophagy
    BNIP3L -->|"targets"| Damaged_Mitochondria
    BNIP3L -->|"mediates"| Mitophagy
    BNIP3L -->|"regulates"| Als
    Proteasome -.->|"degrades"| BNIP3L
    BNIP3L -->|"protects against"| Mitochondrial_Damage
    BNIP3L -->|"regulates"| Autophagy
    MITOPHAGY -->|"regulates"| BNIP3L
    NIX -->|"regulates"| BNIP3L
    BNIP3L -->|"regulates"| Cancer
    BNIP3L -->|"activates"| Mitophagy
    BNIP3L -->|"regulates"| Mitophagy

    style BNIP3L fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (665)

Target	Relation	Type	Str
Mitophagy	involved_in	process	0.95
MITOPHAGY RECEPTOR	associated_with	receptor	0.95
Damaged Mitochondria	targets	phenotype	0.90
Mitophagy	mediates	process	0.90
mitophagy	participates_in	pathway	0.90
Mitophagy Deficiency	involved_in	phenotype	0.90
Cerebral Ischemia	protects_against	disease	0.90
cerebral ischemic injury	protects_against	disease	0.87
neuronal survival	promotes	phenotype	0.85
Als	regulates	disease	0.85
Mitochondrial Damage	protects_against	process	0.80
autophagy pathway	participates_in	pathway	0.80
Mitochondria	interacts_with	cell_type	0.80
Autophagy	regulates	pathway	0.80
Cancer	regulates	disease	0.75
Mitophagy	regulates	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Alzheimer's disease	regulates	disease	0.70
PARKIN	regulates	gene	0.70
Mitophagy	activates	pathway	0.70
Ms	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Heart Failure	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
ALS	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Infection	regulates	disease	0.65
Aging	regulates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Als	associated_with	disease	0.65
Ischemia	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Inflammation	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Aging	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Senescence	activates	disease	0.65
Ms	inhibits	disease	0.65
Ms	activates	disease	0.65
Crohn Disease	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Als	activates	disease	0.65
Heart Failure	inhibits	disease	0.65
Cardiovascular	degrades	disease	0.65
Aging	degrades	disease	0.65
Cardiac	activates	disease	0.65

Incoming (354)

Source	Relation	Type	Str
PROTEASOMES	degrades	enzyme	0.95
cerebral ischemia	causes	disease	0.90
h-2a4e4ad2	targets_gene	hypothesis	0.90
NIX	regulates	gene	0.80
MITOPHAGY	regulates	gene	0.80
CANCER	regulates	gene	0.70
MITOCHONDRIA	regulates	gene	0.70
P62	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
MITOCHONDRIA	associated_with	gene	0.70
AUTOPHAGY	regulates	gene	0.70
NEURODEGENERATION	biomarker_for	gene	0.60
MITOCHONDRIA	activates	gene	0.60
FTLD	biomarker_for	gene	0.60
LYSOSOMAL BIOGENESIS	biomarker_for	gene	0.60
MITOPHAGY	biomarker_for	gene	0.60
DEMENTIA	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AUTOPHAGY	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
CATALASE	interacts_with	gene	0.60
ATM	regulates	gene	0.60
LC3B	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	regulates	gene	0.60
TGFB	activates	gene	0.60
NIX	activates	gene	0.60
RAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
NIX	associated_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Mitochondrial transfer between neurons and glia?

closed · Rounds: 4 · Score: 0.71 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.81 · 2026-04-06