protein

GABARAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABARAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

970Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

GABARAP is a protein involved in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with ALS, Aging, Als. Connected to 490 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GABARAP
Full Name	GABA Type A Receptor Associated Protein
Chromosome	17p13.1
Function	GABARAP is a member of the ATG8 family (MAP1LC3/GABARAP family) with multiple cellular functions
Pathways	Akt, Autophagy, Endocytosis, Er Stress, Lysosomal Degradation
UniProt ID	O95166
NCBI Gene ID	23710
Ensembl ID	ENSG00000138967
OMIM	607418
GeneCards	GABARAP
Human Protein Atlas	GABARAP
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Cancer
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT1, AKT1S1, AMBRA1, AMPK, AMYLOID
KG Connections	969 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GABARAP — AlphaFold O95166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABARAP["GABARAP"] -->|"interacts"| Cancer["Cancer"]
    GABARAP["GABARAP"] -->|"interacts"| Als["Als"]
    GABARAP["GABARAP"] -->|"interacts"| Ms["Ms"]
    GABARAP["GABARAP"] -->|"interacts"| Fibrosis["Fibrosis"]
    GABARAP["GABARAP"] -->|"interacts"| Aging["Aging"]
    GABARAP["GABARAP"] -->|"associated"| Ms_1["Ms"]
    OPTN["OPTN"] -->|"interacts"| GABARAP["GABARAP"]
    CASP3["CASP3"] -->|"interacts"| GABARAP["GABARAP"]
    AKT1["AKT1"] -->|"interacts"| GABARAP["GABARAP"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| GABARAP["GABARAP"]
    style GABARAP fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (599)

Target	Relation	Type	Str
LRRK2	binds	gene	0.95
PLEKHM1	interacts_with	protein	0.90
FLCN-FNIP complex	binds_to	protein	0.90
NUFIP2	interacts_with	protein	0.90
autophagy pathway	participates_in	pathway	0.90
TFEB	inhibits	protein	0.88
FNIP	binds	protein	0.85
FNIP1	binds	protein	0.85
FLCN-FNIP Complex	binds	protein	0.85
lysosomal damage	mediates	process	0.85
Damaged Lysosomes	interacts_with	cell_type	0.85
FLCN	binds	protein	0.85
mTORC1	inhibits	enzyme	0.82
autophagy receptors	component_of	protein	0.80
chaperone-assisted selective autophagy	participates_in	pathway	0.80
autophagy	participates_in	pathway	0.80
LRRK2	regulates	protein	0.80
TFEB	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
RNA	regulates	gene	0.80
LC3	activates	gene	0.80
RNA	activates	gene	0.80
neural stem cells	activates	cell_type	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Autophagy	interacts_with	pathway	0.80
Parkinson	associated_with	disease	0.75
Gaba Receptor Trafficking	promotes	process	0.75
Als	associated_with	disease	0.75
ATG	associated_with	gene	0.70
LC3	associated_with	gene	0.70
LAMP2	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
Autophagy	associated_with	pathway	0.70
UBIQUITIN	associated_with	gene	0.70
TFEB	associated_with	gene	0.70
WIPI2	associated_with	gene	0.70
RB1CC1	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
PIK3C3	associated_with	gene	0.70
Lysosomal Degradation	regulates	pathway	0.70
RAS	regulates	gene	0.70
stem cells	expressed_in	cell_type	0.70
MTOR	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
Mtor	associated_with	pathway	0.70
RAS	activates	gene	0.70
RB1	activates	gene	0.70
MTORC1	regulates	gene	0.70
RB1	regulates	gene	0.70

Incoming (371)

Source	Relation	Type	Str
TRIM22	mediates	protein	0.92
GABA	regulates	gene	0.90
rapamycin	targets	drug	0.90
STING	upregulates	protein	0.85
STING	modulates	protein	0.85
CASM	modulates	protein	0.80
STING	interacts_with	gene	0.80
ATG	regulates	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
LC3	interacts_with	gene	0.80
RB1	associated_with	gene	0.70
GABARAPL1	associated_with	gene	0.70
TAX1BP1	interacts_with	gene	0.70
SQSTM1	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
ATG	activates	gene	0.70
BECN1	regulates	gene	0.70
TRIM22	interacts_with	protein	0.70
CANCER	activates	gene	0.70
LC3B	associated_with	gene	0.70
DNA	regulates	gene	0.70
AMPK	activates	entity	0.60
FTD	activates	entity	0.60
RNA	associated_with	gene	0.60
CYP19A1	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
TRIM22	activates	gene	0.60
DNA	activates	gene	0.60
ATG8	activates	gene	0.60
ATG8	associated_with	gene	0.60
AND	interacts_with	gene	0.60
AND	regulates	gene	0.60
ATG8	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
LYSOSOME	regulates	gene	0.60
CANCER	phosphorylates	entity	0.60
NEURON	associated_with	gene	0.60
ALS	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
RAS	associated_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
ATG8	regulates	gene	0.60
FLCN	interacts_with	gene	0.60
DNAJC13	regulates	gene	0.60
ATG16L1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABARAP in their description or question text

No additional research found

GABARAP

Understanding Entity Pages

Summary

Wiki Pages (8)

GABARAP Gene

GABARAP Protein

STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease

GABARAPL2 Protein

GABARAPL1 — GABA Type A Receptor Associated Protein Like 1

GABARAPL2 Gene

GAIN Protein (GABARAPL2) - GABA-A Receptor Associated Protein Like 2

GABARAPL1 Protein