gene

NBR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NBR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1419Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NBR1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 674 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NBR1
Full Name	Neighbor of BRCA1 Gene 1
Chromosome	17q21.31
Protein Type	Receptor
Function	NBR1 is a selective autophagy receptor
Primary Expression	all brain cell types:
Pathways	Akt, Autophagy, Chaperone, Innate Immunity, Lysosomal Degradation
UniProt ID	Q14596
NCBI Gene ID	10327
Ensembl ID	ENSG00000132716
OMIM	605085
GeneCards	NBR1
Human Protein Atlas	NBR1
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	dimethyl fumarate, rapamycin
Interactions	ABCD3, ABP, ACAT1, ACTB, Actin, Akt
KG Connections	1419 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NBR1 — AlphaFold Q14596 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NBR1 Gene

gene · 778 words

→

NBR1 Protein

protein · 643 words

→

Pathway Diagram

graph TD
    NBR1["NBR1"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NBR1["NBR1"] -->|"interacts"| Dementia["Dementia"]
    NBR1["NBR1"] -->|"interacts"| Als["Als"]
    NBR1["NBR1"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    NBR1["NBR1"] -->|"interacts"| Alzheimer["Alzheimer"]
    NBR1["NBR1"] -->|"interacts"| Parkinson["Parkinson"]
    ACTB["ACTB"] -->|"interacts"| NBR1["NBR1"]
    OPTN["OPTN"] -->|"interacts"| NBR1["NBR1"]
    ULK1["ULK1"] -->|"interacts"| NBR1["NBR1"]
    SMCR8["SMCR8"] -->|"interacts"| NBR1["NBR1"]
    style NBR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (771)

Target	Relation	Type	Str
Autophagy	activates	pathway	1.00
Als	regulates	disease	0.95
Aggrephagy	biomarker_for	process	0.95
Aggrephagy	involved_in	process	0.95
Lipophagy	involved_in	process	0.95
TRIM32	inhibits	protein	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
Myofibrillar Myopathy	biomarker_for	disease	0.90
STAT2	inhibits	protein	0.90
STING	inhibits	protein	0.90
interferon	inhibits	protein	0.90
Myofibrillar Myopathies	biomarker_for	disease	0.90
Disease Severity	correlates_with	phenotype	0.90
Lipid Droplet	binds	organelle	0.85
Selective Autophagy	involved_in	process	0.85
NLR	regulates	gene	0.80
neural stem cells	activates	cell_type	0.80
RB1CC1	regulates	gene	0.80
RB1	regulates	gene	0.80
NDP52	regulates	gene	0.80
neural stem cells	regulates	cell_type	0.80
hepatocellular carcinoma	contributes_to	disease	0.80
SQSTM1	regulates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
RB1	activates	gene	0.80
UBIQUITIN	activates	gene	0.80
Autophagy	associated_with	pathway	0.80
OPTN	associated_with	gene	0.80
Cancer	regulates	disease	0.75
Neurodegeneration	regulates	disease	0.75
Als	interacts_with	disease	0.75
Parkinson	associated_with	disease	0.75
Als	activates	disease	0.75
protein aggregates	recognizes	process	0.70
muscle	expressed_in	cell_type	0.70
autophagy	regulates	pathway	0.70
myofibrillar myopathy	biomarker_for	disease	0.70
lysosomal degradation	activates	process	0.70
aggrephagy	regulates	process	0.70
cargo recognition	regulates	process	0.70
autophagy initiation	activates	process	0.70
ubiquitin	interacts_with	protein	0.70
lipid droplets	recognizes	process	0.70
neurological diseases	associated_with	disease	0.70
necroptosis	participates_in	pathway	0.70
autophagy	activates	process	0.70
MAPT	interacts_with	protein	0.70
amyloid-β	regulates	protein	0.70
MAPT	regulates	protein	0.70
lipophagy	regulates	process	0.70

Incoming (648)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
CALCOCO2	regulates	gene	0.80
LC3	regulates	gene	0.80
BECN1	regulates	gene	0.80
PSMB1	interacts_with	gene	0.80
FIP200	regulates	gene	0.80
p62	interacts_with	protein	0.80
TFEB	associated_with	gene	0.80
STING	activates	gene	0.80
LC3B	activates	gene	0.80
NDP52	associated_with	gene	0.70
CALCOCO2	associated_with	gene	0.70
RB1CC1	associated_with	gene	0.70
BAG3	regulates	protein	0.70
P62	activates	gene	0.70
EIF2AK3	regulates	gene	0.70
BAG3	interacts_with	protein	0.70
LC3	associated_with	gene	0.70
rapamycin	targets	drug	0.70
MAP1LC3	activates	gene	0.70
RB1	associated_with	gene	0.70
OPTN	associated_with	gene	0.70
PIK3C3	associated_with	gene	0.70
P62	associated_with	gene	0.70
Mirc1/Mir17-92a	inhibits	gene	0.70
ERN1	regulates	gene	0.70
GFP	regulates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
BECN1	associated_with	gene	0.70
NDP52	interacts_with	gene	0.70
BAG3	activates	protein	0.70
OPTN	activates	gene	0.70
NDP52	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
CGAS	regulates	gene	0.70
P62	interacts_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
ATG	activates	gene	0.70
ATG	regulates	gene	0.70
DNA	regulates	gene	0.70
MTOR	regulates	gene	0.70
MAP1LC3	regulates	gene	0.70
DNA	activates	gene	0.70
ATG	associated_with	gene	0.70
G3BP1	regulates	gene	0.70
DDIT3	regulates	gene	0.70
NF-ΚB	regulates	gene	0.70
PARKINSON	associated_with	gene	0.70
ALS	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NBR1 in their description or question text

No additional research found