protein

AMBRA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMBRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1091Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AMBRA1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with AD, ALI, ALS. Connected to 563 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	AMBRA1
Aliases	KIAA1731
Chromosome	11p15.5
Protein Family	WD40 repeat-containing proteins
Function	encodes a critical positive regulator of autophagy that plays essential roles in cellular homeostasis, development, and disease pathogenesis[@cecconi2008][@fimia2012].
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Immune Response
UniProt ID	Q9C0A1
NCBI Gene ID	55626
Ensembl ID	ENSG00000164024
GeneCards	AMBRA1
Human Protein Atlas	AMBRA1
Associated Diseases	AD, age-related macular degeneration, aging-related diseases, ALI, Als
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, Actin, ADORA2A, AKT, AKT1, AKT1S1
KG Connections	1091 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AMBRA1 — AlphaFold Q9C0A1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

AMBRA1 Gene

gene · 1882 words

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Pathway Diagram

graph TD
    AMBRA1["AMBRA1"] -->|"regulates"| FAS["FAS"]
    AMBRA1["AMBRA1"] -->|"regulates"| ribosome_protein_biosynthesis["ribosome protein biosynthesis"]
    AMBRA1["AMBRA1"] -->|"regulates"| T_cell_death["T cell death"]
    AMBRA1["AMBRA1"] -->|"protects against"| MAPK_inhibitor_resistance["MAPK inhibitor resistance"]
    AMBRA1["AMBRA1"] -.->|"inhibits"| FAK1["FAK1"]
    AMBRA1["AMBRA1"] -->|"modifies"| Smad4["Smad4"]
    CD28_PI3K_mTORC1_EIF4F_pathway["CD28-PI3K-mTORC1-EIF4F pathway"] -->|"regulates"| AMBRA1["AMBRA1"]
    USP7["USP7"] -->|"modifies"| AMBRA1["AMBRA1"]
    TCR["TCR"] -->|"regulates"| AMBRA1["AMBRA1"]
    CAT["CAT"] -->|"interacts"| AMBRA1["AMBRA1"]
    style AMBRA1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (784)

Target	Relation	Type	Str
BECLIN1	interacts_with	protein	0.95
Macroautophagy	activates	process	0.90
MAPK inhibitor resistance	protects_against	phenotype	0.90
Smad4	modifies	protein	0.90
genomic integrity	protects_against	phenotype	0.90
NRF2	inhibits	protein	0.90
ribosome protein biosynthesis	regulates	pathway	0.90
cyclin D	inhibits	protein	0.90
S-phase entry	regulates	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
epithelial-to-mesenchymal transition	activates	pathway	0.90
CDK6	inhibits	protein	0.90
colitis	causes	disease	0.90
DUB3	inhibits	protein	0.90
T cell death	regulates	phenotype	0.90
breast cancer metastasis	causes	disease	0.90
FAS	regulates	protein	0.90
replication stress	protects_against	phenotype	0.90
oxidative stress	causes	phenotype	0.90
TGF-beta signaling	activates	pathway	0.90
FAK1	inhibits	protein	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.85
PARKINSON'S DISEASE	associated_with	disease	0.85
Cell Proliferation	regulates	process	0.85
NEURODEGENERATION	associated_with	process	0.85
aging-related diseases	implicated_in	disease	0.80
neural stem cells	activates	cell_type	0.80
TFEB	inhibits	protein	0.80
TFE3	inhibits	protein	0.80
apoptosis pathway	participates_in	pathway	0.80
melanoma	protects_against	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Alzheimer Disease	associated_with	disease	0.80
neural stem cells	regulates	cell_type	0.80
Parkinson Disease	associated_with	disease	0.80
ATG	activates	gene	0.80
autophagy	regulates	process	0.80
Autophagy	regulates	pathway	0.80
Age-Related Macular Degeneration	associated_with	disease	0.78
Muscular Dystrophy	associated_with	disease	0.78
age-related macular degeneration	associated_with	disease	0.78
muscular dystrophy	associated_with	disease	0.78
Aging	regulates	disease	0.75
Parkinson	associated_with	disease	0.75
Apoptosis	associated_with	process	0.75
Parkinson's disease	regulates	disease	0.70
Mtor	activates	pathway	0.70
Parkinson's disease	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
HMGB1	interacts_with	gene	0.70

Incoming (307)

Source	Relation	Type	Str
BCL2	associated_with	protein	0.95
CD28-PI3K-mTORC1-EIF4F pathway	regulates	pathway	0.90
USP7	modifies	protein	0.90
TCR	regulates	protein	0.90
AUTOPHAGY	regulates	gene	0.80
PI3K	activates	gene	0.70
BCL-2	interacts_with	gene	0.70
AUTOPHAGY	interacts_with	gene	0.70
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
MTORC1	activates	gene	0.60
GENES	regulates	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
CASP3	regulates	gene	0.60
AKT1	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CGAS	regulates	gene	0.60
CFTR	regulates	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	regulates	gene	0.60
GABARAP	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AMBRA1 in their description or question text

No additional research found