protein

EIF2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

534Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EIF2A is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 296 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	EIF2A
Full Name	Eukaryotic Translation Initiation Factor 2A
Chromosome	3q27.1
Function	Binds the 40S ribosomal subunit
Pathways	Akt, Apoptosis, Er Stress, Wnt
UniProt ID	Q9Y5Q3
NCBI Gene ID	27185
Ensembl ID	ENSG00000144895
OMIM	609994
GeneCards	EIF2A
Human Protein Atlas	EIF2A
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, ALS, ALZHEIMER
KG Connections	533 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EIF2A — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EIF2A["EIF2A"] -->|"regulates"| stress_granules["stress granules"]
    EIF2A["EIF2A"] -->|"interacts"| Cancer["Cancer"]
    EIF2A["EIF2A"] -->|"interacts"| Als["Als"]
    EIF2A["EIF2A"] -->|"interacts"| Ms["Ms"]
    EIF2A["EIF2A"] -->|"interacts"| Fibrosis["Fibrosis"]
    EIF2A["EIF2A"] -->|"interacts"| Aging["Aging"]
    OPTN["OPTN"] -->|"interacts"| EIF2A["EIF2A"]
    CASP3["CASP3"] -->|"interacts"| EIF2A["EIF2A"]
    AKT1["AKT1"] -->|"interacts"| EIF2A["EIF2A"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2A["EIF2A"]
    style EIF2A fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (350)

Target	Relation	Type	Str
protein synthesis	regulates	process	0.90
Protein Translation	regulates	process	0.85
Endoplasmic Reticulum Stress	involved_in	process	0.85
autophagy pathway	participates_in	pathway	0.80
Als	activates	disease	0.75
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
stress granules	regulates	process	0.70
oxidative stress response	participates_in	pathway	0.70
Cancer	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	regulates	disease	0.65
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	activates	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Fibrosis	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Ms	regulates	disease	0.65
Ischemia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Als	contributes_to	disease	0.65
Inflammation	interacts_with	disease	0.65
BCL-2	expressed_in	gene	0.60
Apoptosis	regulates	pathway	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ATG	activates	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
Angiogenesis	interacts_with	pathway	0.60
Immune Response	interacts_with	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Stem Cell	interacts_with	cell_type	0.60
Epithelial	interacts_with	cell_type	0.60
Dendritic Cell	interacts_with	cell_type	0.60
DNA	activates	gene	0.60
RNA	activates	gene	0.60
GENES	activates	gene	0.60
MAP1LC3	activates	gene	0.60
TAR	activates	gene	0.60
frontotemporal dementia	activates	disease	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
TFEB	activates	gene	0.60
Akt	contributes_to	pathway	0.60

Incoming (184)

Source	Relation	Type	Str
TMTD	phosphorylates	compound	0.90
DTG	upregulates	drug	0.85
PERK	phosphorylates	protein	0.85
Stress Granules	phosphorylates	process	0.85
rapamycin	targets	drug	0.70
CYP1A1	activates	gene	0.60
ALS	activates	gene	0.60
RICTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
MITOPHAGY	inhibits	gene	0.60
RB1CC1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EGF	activates	gene	0.60
ATG16L1	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
ATG	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
PHGDH	activates	gene	0.60
ROS	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMPK	activates	gene	0.60
CANCER	phosphorylates	entity	0.60
WNT	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
GABARAP	associated_with	gene	0.60
ATF4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF2A in their description or question text

No additional research found