protein

EEF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EEF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

0Experiments

0Debates

Summary

EEF2 is a protein involved in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Autism. Connected to 80 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	EEF2
Full Name	Eukaryotic Translation Elongation Factor 2 (EEF2)
Chromosome	19p13.3
Protein Type	Gene
Function	is a GTP-dependent molecular motor that catalyzes the translocation step of protein synthesis, moving the peptidyl-tRNA from the A-site to the P-site of the ribosome with each elongation cycle.
Molecular Weight	95.4 kDa
Amino Acids	739 aa
Pathways	Mtor, Synaptic Plasticity, Wnt
GeneCards	EEF2
Human Protein Atlas	EEF2
Associated Diseases	Als, Cardiovascular, Ischemia, Ms
Interactions	ACTB, AGING, AKT, AND, ANG, Bdnf
KG Connections	152 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Eukaryotic Translation Elongation Factor 2 (EEF2)

gene · 2794 words

→

EEF2K — Eukaryotic Elongation Factor 2 Kinase

gene · 1026 words

→

Pathway Diagram

graph TD
    EEF2["EEF2"] -->|"regulates"| BDNF["BDNF"]
    EEF2["EEF2"] -.->|"inhibits"| NMDAR["NMDAR"]
    EEF2["EEF2"] -.->|"inhibits"| eEF2K["eEF2K"]
    EEF2["EEF2"] -->|"phosphorylates"| TAOK2["TAOK2"]
    EEF2["EEF2"] -->|"binds"| CPEB2["CPEB2"]
    EEF2["EEF2"] -->|"phosphorylates"| LRRK2["LRRK2"]
    P38["P38"] -->|"activates"| EEF2["EEF2"]
    AKT["AKT"] -->|"activates"| EEF2["EEF2"]
    CD4["CD4"] -->|"interacts"| EEF2["EEF2"]
    MAPK3["MAPK3"] -->|"interacts"| EEF2["EEF2"]
    style EEF2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:EEF2	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
BDNF	upregulates	gene	0.90
NMDAR	inhibits	receptor	0.90
CPEB2	binds	gene	0.90
TAOK2	phosphorylates	gene	0.90
eEF2K	inhibits	gene	0.90
eIF2α	phosphorylates	protein	0.80
eIF2s2	phosphorylates	protein	0.80
HIF-1α	inhibits	gene	0.80
LDHA	binds	gene	0.80
NADH	binds	chemical	0.80
Stm1	binds	protein	0.80
LRRK2	phosphorylates	gene	0.80
Antidepressant Response	mediates	phenotype	0.78
Necroptosis	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Fibrosis	expressed_in	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Depression	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Depression	inhibits	disease	0.65
Aging	activates	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Autism	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Ras	inhibits	protein	0.60
TNF	activates	gene	0.60
REST	inhibits	gene	0.60
SOD1	regulates	gene	0.60
FZD9	regulates	gene	0.60
FZD2	regulates	gene	0.60
GRB2	regulates	gene	0.60
EIF2AK2	regulates	gene	0.60
CREBBP	regulates	gene	0.60
ANG	activates	gene	0.60
DDB1	activates	gene	0.60
Mapk	activates	pathway	0.60
Mapk	interacts_with	pathway	0.60
Wnt	regulates	pathway	0.60
APOPTOSIS	associated_with	gene	0.60

Incoming (47)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:EEF2	data_in	dataset_row	0.00
Cholix	targets	entity	1.00
ds-83b31ef18d49	data_in	dataset	1.00
P38	activates	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD19	interacts_with	gene	0.60
BNIP3	associated_with	gene	0.60
TNF	activates	gene	0.60
NLRP3	inhibits	gene	0.60
BDNF	activates	gene	0.60
GFAP	activates	gene	0.60
SNAP25	activates	gene	0.60
PSD95	activates	gene	0.60
EEF2K	inhibits	gene	0.60
HDAC1	activates	gene	0.60
ROS	activates	gene	0.60
CHR2	activates	gene	0.60
RPL14	associated_with	gene	0.60
MITOPHAGY	associated_with	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
PIK3CA	regulates	gene	0.60
CD44	regulates	gene	0.60
SRC	regulates	gene	0.60
ARID1A	associated_with	gene	0.60
CANX	associated_with	gene	0.60
UBE2K	associated_with	gene	0.60
AND	activates	gene	0.60
DEPRESSION	activates	gene	0.60
AND	regulates	gene	0.60
DEPRESSION	inhibits	gene	0.60
PKC	activates	gene	0.60
ERK	activates	gene	0.60
JNK	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
MIRNAS	regulates	gene	0.60
MAPK	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
GENES	activates	gene	0.60
CAMKII	activates	gene	0.60
AKT	activates	gene	0.60
BDNF	regulates	gene	0.60
MET	inhibits	gene	0.60
MTOR	activates	gene	0.60
mTOR	activates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EEF2 in their description or question text

No additional research found