disease

COPD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COPD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

430Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	6 GENES, AMPK, BCL2, BECN1, CTSD, DRP1, FEATURE DEGS, FOXO3
Therapeutic Agents	Anti-Inflammatory Therapy, BYF
KG Connections	309 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    COPD["COPD"] -->|"associated"| Persistent_Cough["Persistent Cough"]
    style Persistent_Cough fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"associated"| Sputum_Production["Sputum Production"]
    style Sputum_Production fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"associated"| Sarcopenia["Sarcopenia"]
    style Sarcopenia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"interacts"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style FRONTOTEMPORAL_DEMENTIA fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| ROS["ROS"]
    style ROS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    COPD["COPD"] -->|"activates"| ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    style ENDOPLASMIC_RETICULUM fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Chronic_Inflammation["Chronic Inflammation"] -->|"associated"| COPD["COPD"]
    style Chronic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Neutrophilic_Inflammation["Neutrophilic Inflammation"] -->|"contributes to"| COPD["COPD"]
    style Neutrophilic_Inflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    STAT3["STAT3"] -->|"therapeutic target"| COPD["COPD"]
    style STAT3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    HUB_GENES["HUB GENES"] -->|"risk factor for"| COPD["COPD"]
    style HUB_GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Cytokines["Cytokines"] -->|"contributes to"| COPD["COPD"]
    style Cytokines fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    style COPD fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (170)

Target	Relation	Type	Str
Airflow Limitation	causes	phenotype	0.95
Persistent Cough	causes	phenotype	0.90
Persistent Cough	associated_with	phenotype	0.90
Sputum Production	associated_with	phenotype	0.90
Sputum Production	causes	phenotype	0.90
Als	activates	disease	0.85
Inflammation	activates	disease	0.75
Als	regulates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Immune Response	contributes_to	pathway	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
Sarcopenia	associated_with	disease	0.70
Oxidative Stress	causes	pathway	0.70
Pi3K/Akt	inhibits	pathway	0.70
Inflammation	causes	disease	0.65
Inflammation	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Lung Cancer	contributes_to	disease	0.65
Autophagy	associated_with	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Dysbiosis	implicated_in	pathway	0.60
Mtor	associated_with	pathway	0.60
Senescence	causes	pathway	0.60
Ferroptosis	regulates	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Nf-Κb	causes	pathway	0.60
Senescence	therapeutic_target	pathway	0.60
Mapk	inhibits	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Epigenetic	contributes_to	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Immune Response	inhibits	pathway	0.60
Autophagy	activates	pathway	0.60
Senescence	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Als	associated_with	disease	0.55
Pulmonary Fibrosis	associated_with	disease	0.55
Als	inhibits	disease	0.55
Aging	activates	disease	0.55
Als	expressed_in	disease	0.55
Hepatitis	therapeutic_target	disease	0.55
Aging	inhibits	disease	0.55
PYROPTOSIS	implicated_in	phenotype	0.55
Asthma	regulates	disease	0.55
Cystic Fibrosis	associated_with	disease	0.55
Asthma	contributes_to	disease	0.55
Aging	therapeutic_target	disease	0.55
Fibrosis	associated_with	disease	0.55
Proteins	activates	protein	0.50

Incoming (260)

Source	Relation	Type	Str
Byf	treats	drug	0.95
Chronic Inflammation	associated_with	process	0.95
Neutrophilic Inflammation	contributes_to	process	0.95
STAT3	therapeutic_target	protein	0.90
Inflammation	involved_in	process	0.90
Hub Genes (9 Novel)	biomarker_for	biomarker	0.90
Hub Genes (2 Genes)	risk_factor_for	biomarker	0.85
INFLAMMATION	activates	gene	0.85
HUB GENES	risk_factor_for	gene	0.85
INFLAMMATION	therapeutic_target	gene	0.85
Cytokines	contributes_to	biological_process	0.80
FEATURE DEGS	causes	gene	0.80
OXIDATIVE STRESS	causes	gene	0.75
INFLAMMATION	causes	gene	0.75
CHIP	associated_with	disease	0.75
OXIDATIVE STRESS	therapeutic_target	gene	0.75
6 GENES	causes	gene	0.75
Anti-Inflammatory Therapy	treats	drug	0.75
AKT	inhibits	gene	0.75
PI3K	inhibits	gene	0.75
INFLAMMATION	regulates	gene	0.75
INFLAMMATION	associated_with	gene	0.75
CANCER	contributes_to	gene	0.75
BYF	treats	drug	0.72
Epigenetic Factors	contributes_to	biological_process	0.70
Protease-Antiprotease Imbalance	contributes_to	biological_process	0.70
AKT	therapeutic_target	gene	0.65
MMP9	therapeutic_target	gene	0.65
CANCER	therapeutic_target	gene	0.65
NFKB1	therapeutic_target	gene	0.65
ESR1	therapeutic_target	gene	0.65
CASP3	therapeutic_target	gene	0.65
PTGS2	therapeutic_target	gene	0.65
EGFR	therapeutic_target	gene	0.65
PPARG	therapeutic_target	gene	0.65
HSP90AA1	therapeutic_target	gene	0.65
SRC	therapeutic_target	gene	0.65
NRF2	regulates	gene	0.65
FERROPTOSIS	regulates	gene	0.65
KEAP1	activates	gene	0.65
GPX4	causes	gene	0.65
GENES	contributes_to	gene	0.65
OXIDATIVE STRESS	associated_with	gene	0.65
Cancer	contributes_to	disease	0.65
NF-ΚB	inhibits	gene	0.65
CYTOKINES	inhibits	gene	0.65
PI3K	therapeutic_target	gene	0.65
RAGE	therapeutic_target	gene	0.65
DNA	therapeutic_target	gene	0.65
DSDNA	therapeutic_target	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COPD in their description or question text

No additional research found