gene

PINK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PINK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3547Connections

14Hypotheses

7Analyses

50Outgoing

50Incoming

2Experiments

13Debates

Summary

PINK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 1749 entities in the SciDEX knowledge graph.

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AI-generated illustration · click image to enlarge

Regenerate portrait ↻

🧬 Gene Info

Gene Symbol	PINK1
Chromosome	1p36.12
Protein Family	Serine/threonine kinase family
Protein Type	Kinase
Function	is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary Expression	Mitochondrial outer membrane
Subcellular Localization	</th><td>Mitochondrial inner membrane (OMM upon activation)</td></tr>
Molecular Weight	63 kDa
Pathways	Amyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt ID	Q9BXM7
NCBI Gene ID	65018
Ensembl ID	ENSG00000158828
OMIM	608309
GeneCards	PINK1
Human Protein Atlas	PINK1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	BGP-15, Canagliflozin, CANAGLIFLOZIN, DEFERIPRONE, dimethyl fumarate, Gastrodin
Interactions	ABCD3, ABP, ACHE, Actin, AD, AGING
SciDEX Hypotheses	Mitophagy collapse via PINK1-PRKN is the primary a Dose-Response Framework: PINK1/Parkin Mitophagy as PINK1/PARK2-Mediated Mitophagy Enhancement for Neu (+4 more)
KG Connections	3546 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — PINK1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6EQI — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q9BXM7 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PINK1["PINK1"] -->|"causes"| PD["PD"]
    PINK1["PINK1"] -->|"phosphorylates"| UBIQUITIN["UBIQUITIN"]
    PINK1["PINK1"] -->|"activates"| PARKIN["PARKIN"]
    PINK1["PINK1"] -->|"activates"| MITOPHAGY["MITOPHAGY"]
    PINK1["PINK1"] -->|"recruits"| NDP52["NDP52"]
    PINK1["PINK1"] -->|"recruits"| OPTINEURIN["OPTINEURIN"]
    propionic_acid["propionic acid"] -->|"activates"| PINK1["PINK1"]
    CAT["CAT"] -->|"interacts"| PINK1["PINK1"]
    OPTN["OPTN"] -->|"interacts"| PINK1["PINK1"]
    DNM1L["DNM1L"] -->|"interacts"| PINK1["PINK1"]
    style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1941)

Target	Relation	Type	Str
AUTOPHAGY	regulates	gene	1.00
Cancer	therapeutic_target	disease	1.00
PARKINSON'S DISEASE	activates	gene	1.00
PARKINSON	activates	gene	1.00
MITOPHAGY	activates	pathway	1.00
NEURODEGENERATION	activates	gene	1.00
Autophagy	regulates	pathway	1.00
Tumor	activates	disease	1.00
PARKIN	activates	protein	1.00
Mitophagy	regulates	pathway	1.00
UBIQUITIN	regulates	gene	1.00
Mitophagy	inhibits	pathway	1.00
CANCER	activates	gene	1.00
Neurodegeneration	activates	disease	1.00
PARKIN	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
PRKN	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
Als	activates	disease	1.00
Als	regulates	disease	1.00
ROS	activates	gene	1.00
Parkinson	associated_with	disease	1.00
Mitochondrial Function	associated_with	pathway	1.00
MITOPHAGY	inhibits	gene	1.00
Inflammation	activates	disease	1.00
Parkinson	causes	disease	1.00
Mtor	activates	pathway	1.00
Aging	activates	disease	1.00
Alzheimer	activates	disease	1.00
PARKIN	regulates	protein	1.00
Neuroinflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
MTOR	activates	gene	1.00
Mitophagy	activates	pathway	1.00
AMPK	activates	gene	1.00
Parkinson	regulates	disease	1.00
MITOCHONDRIA	associated_with	gene	1.00
P62	activates	gene	1.00
Mitochondrial Function	activates	pathway	1.00
PTEN	activates	gene	1.00
PARKINSON	associated_with	gene	1.00
MITOCHONDRIA	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
ALZHEIMER	activates	gene	1.00
Apoptosis	activates	pathway	1.00
Parkinson	activates	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
GENES	activates	gene	1.00
MITOCHONDRIA	regulates	gene	1.00
PARKIN	inhibits	gene	1.00

Incoming (1606)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	1.00
PARKIN	activates	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
MITOPHAGY	associated_with	gene	1.00
MITOPHAGY	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PTEN	activates	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
PARKIN	regulates	gene	1.00
PARKIN	associated_with	gene	1.00
MITOPHAGY	regulates	gene	0.98
PHB2	associated_with	protein	0.95
MTK458	activates	drug	0.95
SRT2104	upregulates	drug	0.92
MYC	activates	gene	0.90
PARK2	phosphorylates	gene	0.90
ATAD3A	inhibits	protein	0.90
MAPK pathway inhibition	contributes_to	drug	0.90
SPAUTIN-1	stabilizes	compound	0.90
SIRT3	deacetylates	protein	0.90
Mitochondrial Import Pathway Blockade	activates	mechanism	0.90
MIF	inhibits	protein	0.90
P53	represses	protein	0.90
APOPTOSIS	associated_with	gene	0.90
mitochondrial membrane potential loss	activates	phenotype	0.90
AMYLOID	associated_with	gene	0.90
Mitochondrial membrane potential loss	activates	mechanism	0.90
TOM	binds	protein	0.90
Mitochondrial Import Pathway	associated_with	process	0.90
Spautin-1	associated_with	compound	0.90
h-a11f71b5	targets	hypothesis	0.90
TIM23	interacts_with	protein	0.90
PSMD14	activates	protein	0.90
DIZE	upregulates	drug	0.90
PARL	associated_with	protein	0.90
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.90
icaritin	activates	drug	0.88
mitochondrial damage	activates	phenotype	0.88
Hesperetin	upregulates	compound	0.85
Gastrodin	activates	drug	0.85
Nrf2	upstream_of	gene	0.85
FOXO3	upregulates	gene	0.85
CRISPR-Cas9	targets	process	0.85
PINK1	encodes	gene	0.85
isoginkgetin	associated_with	compound	0.85
BAP31	interacts_with	protein	0.85
TIMM23 complex disruption	activates	mechanism	0.85
APOE	inhibits	gene	0.85
SIRT1	upregulates	protein	0.85
CKLF	upregulates	protein	0.85

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifie	0.780	neurodegeneration	-
GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Si	0.747	neurodegeneration	-
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.738	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
OPTN/TBK1 mutations create selective vulnerability by blocki	0.670	neurodegeneration	What are the neuron-specific effects of
Dose-Response Framework: PINK1/Parkin Mitophagy as the Criti	0.614	neurodegeneration	View

Mitophagy collapse via PINK1-PRKN is the primary autophagy l	0.614	neurodegeneration	What specific autophagy pathways are def
PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflamma	0.571	Neuroinflammation	Immune atlas neuroinflammation analysis
TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma	0.560	neurodegeneration	Does TRPML1 enhancement cause therapeuti
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor	0.529	neurodegeneration	Mitochondrial transfer between neurons a
Mitochondrial-Targeted PINK1/Parkin Pathway Activation for N	0.500	neurodegeneration	Test Hypothesis Fixtures
PINK1/PARK2-LC3 Mitophagy Enhancement	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis
Mitophagy Enhancement Blocks STING-Mediated Neuroinflammatio	0.380	Neuroinflammation	Immune atlas neuroinflammation analysis
PINK1/PARK2 Mitophagy Enhancement for Microglial Polarizatio	0.380	Neuroinflammation	Immune atlas neuroinflammation analysis
Combination Gene Therapy Targeting RGS6 and Parkin or PINK1	0.317	neurodegeneration	Does RGS6 upregulation or D2 autorecepto

Mentioning Analyses (7)

Scientific analyses that reference this entity

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

neurodegeneration | 2026-04-11 | 0 hypotheses

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

neurodegeneration | 2026-04-11 | 0 hypotheses

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

neurodegeneration | 2026-04-08 | 1 hypotheses Top: 0.380

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.869

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.822

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A
PINK1 mutation carriers frequently report experiencing pain.	genetic_association	Parkinson's disease	0.500	0.00	human	extracted	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026	0
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026	0
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026	0
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Yuanyuan Fang; Mengqiu Deng; Kesheng Hua	Cell communication and signali	2026	0
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026	0
SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189]	["Cho S", "Jo E", "Jang H"]	Scientific reports	2026	0
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026	0
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026	0
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026	0
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025	0
Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832]	["Tang M", "Outissint I", "Chen Y", "Gon	Journal of cellular biochemist	2025	0
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025	0
Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261]	Yang R, Meng X, Zhao W, Xu SQ, Wang SY,	Bioorganic chemistry	2025	0
Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458]	Pradeepkiran JA, Kshirsagar S, Alvir RV,	Biochimica et biophysica acta.	2025	0
The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632]	Wang H, Liu J, Tian YR, Zhu F, Li H	Journal of Alzheimer's disease	2025	0
Identification of mitophagy-associated proteins profile as potential plasma biom [PMID:37990436]	["Qian S", "He H", "Xiong X", "Ai R", "W	CNS neuroscience & therapeutic	2024	0
Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the [PMID:38405353]	["Pinjala P", "Tryphena K", "Kulkarni A"	Journal of Alzheimer's disease	2024	0

Debates (13)

Multi-agent debates referencing this entity

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

closed · Rounds: 4 · Score: 0.12 · 2026-04-27

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

closed · Rounds: 4 · Score: 0.42 · 2026-04-27

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

closed · Rounds: 4 · Score: 0.47 · 2026-04-27

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

closed · Rounds: 4 · Score: 0.52 · 2026-04-27

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

closed · Rounds: 4 · Score: 0.72 · 2026-04-27

The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed a critical gap: while excitatory neurons show mitochondrial

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

closed · Rounds: 4 · Score: 0.94 · 2026-04-10

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning PINK1 in their description or question text

PINK1

Understanding Entity Pages

Summary

Wiki Pages (16)

PINK1 Protein

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

PINK1-Parkin Mitophagy Complex

Mitophagy Gate Therapy: PINK1/Parkin + TFEB Priming

PINK1-Deficient Dopaminergic Neurons

PINK1 Activators for Parkinson's Disease

PINK1/PARKIN Mitophagy Activators for Parkinson's Disease

PINK1-Parkin Mitophagy Activators

PINK1 — PTEN Induced Kinase 1

PINK1

PINK1-Deficient Dopamine Neurons

PINK1/Parkin Pathway in Parkinson's Disease

PINK1/Parkin Activators

PINK1 (PTEN-Induced Kinase 1)

PINK1-Deficient Dopamine Neurons

PINK1 — PTEN Induced Kinase 1 (PARK6)

Pathway Diagram

Outgoing (1941)

Incoming (1606)

Targeting Hypotheses (14)

Mentioning Analyses (7)

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Mitochondrial transfer between astrocytes and neurons

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Mechanistic role of APOE in neurodegeneration

Experiments (2)

Related Papers (20)

Debates (13)

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit

The debate revealed a critical gap: while excitatory neurons show mitochondrial

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

Related Research

Mitophagy collapse via PINK1-PRKN is the primary autophagy lesion after irradiat

PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control

TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis

PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor Mitochondria

Mitochondrial-Targeted PINK1/Parkin Pathway Activation for Neuroprotection

PINK1/PARK2-LC3 Mitophagy Enhancement

Mitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS

PINK1/PARK2 Mitophagy Enhancement for Microglial Polarization

Combination Gene Therapy Targeting RGS6 and Parkin or PINK1 to Address Mitochond