gene

DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6612Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DEMENTIA is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, ALZHEIMER. Connected to 1765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DEMENTIA
Amyloid-beta	Antibodies, small molecules, and vaccines targeting Aβ production, aggregation, and clearance
Tau pathology	Tau aggregation inhibitors, anti-tau antibodies, and tau vaccination strategies
Neuroinflammation	Microglial modulators, NLRP3 inhibitors, and anti-inflammatory approaches
Synaptic protection	Synaptic plasticity enhancers and neuroprotective compounds[@Cummings2024][@long2024]
Alpha-synuclein	Targeting a-synuclein aggregation, propagation, and clearance
LRRK2	Kinase inhibitors and genetic modifiers for LRRK2-associated PD
GBA	Enzyme modulators for GBA-associated Parkinson's disease
Dopaminergic preservation	Neuroprotective and disease-modifying approaches[@smith2023]
TDP-43 pathology	Targeting protein aggregation and cellular stress pathways
C9orf72	Approaches addressing hexanucleotide repeat expansions
FTD subtypes	Behavior variant FTD and primary progressive aphasia therapeutics
Gene therapy	AAV-delivered gene silencing and replacement
Cell therapy	Cell replacement and cellular rejuvenation approaches
AI/ML drug discovery	Machine learning approaches to target identification and compound optimization
Biomarker-driven development	Precision medicine approaches using biomarkers for patient stratification[@chen2024]
Associated Diseases	Aging, Als, Alzheimer, Alzheimer Disease
Known Drugs/Compounds	EMPAGLIFLOZIN, Ginsenoside Rg1, LECANEMAB, MEMANTINE, Quercetin, RAPAMYCIN
Interactions	6-OHDA, ABCB1, ABCD3, ACTB, Actin, AGING
KG Connections	3973 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

dementia-discovery-fund

institution · 3270 words

→

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Dementia["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Aging["Aging"]
        DEMENTIA["DEMENTIA"] -->|"associated with"| Alzheimer_1["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Alzheimer_2["Alzheimer"]
        DEMENTIA["DEMENTIA"] -->|"causes"| Dementia_3["Dementia"]
        APP["APP"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER["ALZHEIMER"] -->|"associated with"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_S_DISEASE_6["ALZHEIMER'S DISEASE"] -->|"causes"| DEMENTIA["DEMENTIA"]
        ALZHEIMER_7["ALZHEIMER"] -->|"causes"| DEMENTIA["DEMENTIA"]
    end
    subgraph Signaling["Signaling"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Alzheimer["Alzheimer"]
        DEMENTIA["DEMENTIA"] -.->|"inhibits"| Dementia_4["Dementia"]
        DEMENTIA["DEMENTIA"] -->|"activates"| Dementia_5["Dementia"]
    end
    subgraph Interactions["Interactions"]
        ALS["ALS"] -->|"interacts with"| DEMENTIA["DEMENTIA"]
    end
    style DEMENTIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_3 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_4 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Dementia_5 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE_6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (2932)

Target	Relation	Type	Str
Als	therapeutic_target	disease	1.00
Alzheimer	causes	disease	1.00
Alzheimer	biomarker_for	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Als	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Aging	biomarker_for	disease	1.00
Alzheimer	associated_with	disease	1.00
Dementia	treats	disease	1.00
Alzheimer	treats	disease	1.00
Aging	biomarker_for	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
ALZHEIMER	causes	gene	1.00
Inflammation	therapeutic_target	disease	1.00
ALZHEIMER	associated_with	gene	1.00
Als	treats	disease	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Dementia	activates	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Als	biomarker_for	disease	1.00
ALZHEIMER'S DISEASE	biomarker_for	gene	1.00
Alzheimer	causes	disease	1.00
Als	activates	disease	1.00
ALZHEIMER	activates	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
Als	causes	disease	1.00
Aging	associated_with	disease	1.00
Alzheimer	activates	disease	1.00
Dementia	causes	disease	1.00
Neurodegeneration	activates	disease	1.00
MICROGLIA	activates	cell_type	1.00
Dementia	regulates	disease	1.00
ALZHEIMER	biomarker_for	gene	1.00
Neuroinflammation	associated_with	disease	1.00
Dementia	biomarker_for	disease	1.00
Neurodegeneration	causes	disease	1.00
Dementia	associated_with	disease	1.00
ALZHEIMER	therapeutic_target	gene	1.00
AMYLOID	therapeutic_target	gene	1.00
Parkinson	associated_with	disease	1.00
Aging	activates	disease	1.00
Dementia	therapeutic_target	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
Inflammation	activates	disease	1.00
Parkinson	causes	disease	1.00

Incoming (3680)

Source	Relation	Type	Str
entities-astrocytes	associated_with	wiki	0.00
Neuroinflammation	activates	disease	1.00
ALZHEIMER	therapeutic_target	gene	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
APOPTOSIS	associated_with	gene	1.00
APOE	associated_with	gene	1.00
Neurodegeneration	causes	disease	1.00
ALZHEIMER	causes	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
APP	associated_with	gene	1.00
ALZHEIMER'S DISEASE	causes	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Inflammation	associated_with	disease	1.00
MAPT	associated_with	gene	1.00
ALZHEIMER	causes	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
ALZHEIMER'S DISEASE	causes	gene	1.00
DEMENTIA	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
PARKINSON	associated_with	gene	1.00
ALZHEIMER	activates	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
TAU	causes	gene	1.00
Neurodegeneration	associated_with	disease	1.00
INFLAMMATION	associated_with	gene	1.00
DEMENTIA	causes	gene	1.00
Alzheimer	biomarker_for	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
DEMENTIA	activates	gene	1.00
Neurodegeneration	activates	disease	1.00
NEURON	causes	gene	1.00
Parkinson	associated_with	disease	1.00
TNF	associated_with	gene	1.00
NEURODEGENERATION	causes	gene	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
ALZHEIMER	treats	gene	1.00
GENES	activates	gene	1.00
Aging	biomarker_for	disease	1.00
TAU	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
TARDBP	associated_with	gene	1.00
TAU	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
Als	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
NEURON	associated_with	gene	1.00
AMYLOID	associated_with	gene	1.00

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Direct ISR target engagement likely requires trazodone doses	0.590	neurodegeneration	-
A lower trazodone dose of 50-100 mg nightly may be sufficien	0.580	neurodegeneration	-
C1Q-Glia Cross-Talk in Vascular Dementia Pathogenesis	0.470	neuroinflammation	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEMENTIA in their description or question text

No additional research found