protein

STING1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STING1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1294Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

STING1 is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ALI, ALS. Connected to 592 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	STING1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	DNA sensing: cGAS (cyclic GMP-AMP synthase) binds cytosolic dsDNA from any source — mitochondrial, nuclear, microbial, or retrotransposon-derived
Mechanism of Action	Small molecule agonists or antagonists of cGAS-STING pathway activation
Druggability	Low (0.40)
Clinical Stage	Phase II
Pathways	Akt, Autophagy, Immune Response, Wnt, innate_immune_response
UniProt ID	A0A494C1N5
Ensembl ID	ENSG00000184584
GeneCards	STING1
Human Protein Atlas	STING1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	cGAMP, palmitic acid, Palmitic Acid, PA treatment, rapamycin, VS-X4
Interactions	ABCD3, ACOX1, Actin, Adiponectin, ADIPOQ, AKT1
SciDEX Target	View Target Profile (3 clinical trials)
SciDEX Hypotheses	Mitochondrial NAD+ Salvage Enhancement
KG Connections	1293 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — STING1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

4LOH — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A494C1N5 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STING1 Gene

gene · 977 words

→

Pathway Diagram

graph TD
    STING1["STING1"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    STING1["STING1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    STING1["STING1"] -->|"interacts"| CGAS["CGAS"]
    STING1["STING1"] -->|"interacts"| DNASE2["DNASE2"]
    STING1["STING1"] -->|"co discussed"| C3["C3"]
    STING1["STING1"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    MITOCHONDRIAL_DNA["MITOCHONDRIAL_DNA"] -->|"activates"| STING1["STING1"]
    CGAS_1["CGAS"] -->|"interacts"| STING1["STING1"]
    DNASE2_2["DNASE2"] -->|"interacts"| STING1["STING1"]
    MMP9["MMP9"] -->|"co discussed"| STING1["STING1"]
    style STING1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (633)

Target	Relation	Type	Str
Type I Interferon Signaling	activates	pathway	0.95
Savi	causes	disease	0.95
Interferon-Stimulated Genes	upregulates	pathway	0.90
Autoimmunity	associated_with	disease	0.90
INTERFERON ALPHA	upregulates	protein	0.90
PD-L1	associated_with	protein	0.90
Type I Interferonopathy	causes	disease	0.90
IRF3	activates	protein	0.90
type I interferon	associated_with	protein	0.90
DNA Sensing Pathway	mediates	pathway	0.90
Macroautophagy	activates	process	0.90
TYPE_I_IFN	activates	protein	0.87
Niemann-Pick Disease Type C	mediates	disease	0.85
MTORC1 Complex Formation	mediates	process	0.85
Lipid Accumulation	regulates	phenotype	0.85
Autophagy	mediates	process	0.85
Ferroptotic Cell Death	mediates	process	0.85
MTORC1	activates	protein	0.82
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
BRAIN INFLAMMATION	causes	gene	0.80
NFKB	regulates	gene	0.80
FERROPTOSIS	causes	gene	0.80
NEURODEGENERATION	causes	gene	0.80
GPX4	regulates	gene	0.80
NF-κB	activates	protein	0.80
MAPK	activates	protein	0.80
neural stem cells	regulates	cell_type	0.80
neural stem cells	activates	cell_type	0.80
SQSTM1	interacts_with	protein	0.80
autophagy	associated_with	phenotype	0.80
TRAF6	interacts_with	protein	0.80
lysosome-dependent cell death	associated_with	phenotype	0.80
neuroinflammation	triggers	process	0.80
Infection	regulates	disease	0.75
Autoimmune	activates	disease	0.75
interferon response	suppresses	process	0.75
Als	therapeutic_target	disease	0.75
Nonalcoholic Steatohepatitis	involved_in	disease	0.75
Als	activates	disease	0.75
AUTOPHAGY	activates	pathway	0.74
autophagy	activates	pathway	0.74
lipophagy	inhibits	pathway	0.72
SAVI	causes	disease	0.72
DNA	regulates	gene	0.70
Parkinson's disease	associated_with	disease	0.70
microglia	expressed_in	cell_type	0.70
multiple sclerosis	associated_with	disease	0.70
Parkinson's disease	activates	disease	0.70
aging	associated_with	process	0.70

Incoming (661)

Source	Relation	Type	Str
Palmitic Acid	activates	compound	0.90
palmitic acid	activates	drug	0.90
Lipotoxicity	activates	process	0.90
cyclic GMP-AMP	activates	protein	0.90
CGAS	activates	gene	0.90
TLR2	regulates	protein	0.90
cGAS	activates	protein	0.90
Mitochondrial Dna Stress	activates	process	0.90
STIM1	binds	gene	0.90
h-bbe4540f	targets_gene	hypothesis	0.90
h-3da804f5	targets_gene	hypothesis	0.90
h-1a34778f	targets_gene	hypothesis	0.90
Mitochondrial DNA Stress	activates	process	0.85
CSNK1A1	phosphorylates	protein	0.85
SQSTM1	mediates	protein	0.85
h-bbe4540f	targets	hypothesis	0.80
PA treatment	activates	drug	0.80
LC3	regulates	gene	0.80
MTORC1	regulates	gene	0.80
h-1a34778f	targets	hypothesis	0.80
ATG	regulates	gene	0.80
ATG	activates	gene	0.80
ROS	regulates	gene	0.80
rapamycin	targets	drug	0.80
CSNK1A1	inhibits	gene	0.72
AUTOPHAGY	inhibits	pathway	0.72
MITOCHONDRIAL_DNA	activates	gene	0.72
PA	activates	drug	0.72
cGAMP	activates	drug	0.72
mtDNA_stress	activates	phenotype	0.72
NGLY1	activates	gene	0.70
SQSTM1	activates	gene	0.70
BECN1	regulates	gene	0.70
RB1	activates	gene	0.70
VS-X4	inhibits	drug	0.70
STAT3	regulates	protein	0.70
NLR	regulates	gene	0.70
ATM	regulates	gene	0.70
IFN	regulates	gene	0.70
MTOR	regulates	gene	0.70
NBR1	regulates	gene	0.70
NDP52	interacts_with	gene	0.70
MAP1LC3B	regulates	gene	0.70
NLR	activates	gene	0.70
JNK	regulates	gene	0.70
RB1	regulates	gene	0.70
OPTN	regulates	gene	0.70
CGAS	regulates	gene	0.70
alpha-synuclein	activates	protein	0.70
FIP200	regulates	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial NAD+ Salvage Enhancement	0.639	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (2)

Scientific analyses that reference this entity

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 45 hypotheses Top: 0.990

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107]	Lan T, Shang D, Lin L, Wang H, Zou J et	Autophagy	2026
cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeut [PMID:41481960]	Fazal F, Dar NJ, Ahamad S, Khan S, Bano	Mol Aspects Med	2026
Opportunities and challenges of targeting cGAS-STING in cancer. [PMID:41486397]	Lu C, Wang W, Fu YX	Nat Rev Cancer	2026
CircZBTB44-Encoded Peptide ZBTB44-342aa Alleviates Aortic Valve Calcification Vi [PMID:41487094]	Hu D, Lin Y, Huang H, Xian G, Chen Y et	Circ Res	2026
Inhibiting macrophage-derived lactate transport restores cGAS-STING signalling a [PMID:41495200]	Li D, Cui G, Yang K, Lu C, Jiang Y et al	Nat Cell Biol	2026
cGAS-STING activation in Parkinson's Disease: From mechanisms to Disease-Modifyi [PMID:41500413]	Solomon J, Mandal S, Aran KR	Gene	2026
Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated im [PMID:41512867]	Li L, Ye Q, Ma J, Wang Z, Liu T et al.	Cancer Cell	2026
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026
Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheim [PMID:41742243]	Zhang M, Lan Y, Yue Q, He J, Li L et al.	J Nanobiotechnology	2026

Debates (2)

Multi-agent debates referencing this entity

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03