gene

XBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

XBP1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 162 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	XBP1
Full Name	X-Box Binding Protein 1
Aliases	Page for XBP1
Chromosome	22q12.1
Protein Type	Transcription Factor
Function	ER Expansion and Biogenesis: Increases ER membrane synthesis and volume
Primary Expression	Brain, Liver, Pancreas, Immune cells
Molecular Weight	29 kDa
Amino Acids	261 aa
Pathways	Autophagy, Er Stress, Glycolysis, Mitophagy, Unfolded Protein Response
UniProt ID	P17861
NCBI Gene ID	7499
Ensembl ID	ENSG00000143419
GeneCards	XBP1
Human Protein Atlas	XBP1
Associated Diseases	Tumor
Interactions	AKT, AND, APOE4, ATF3, ATF4, ATF6
KG Connections	261 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: XBP1 — AlphaFold P17861 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    XBP1["XBP1
ER Stress
Response Factor"]
    
    ER_Stress["ER Stress
Pathway"]
    HSPA5["HSPA5
(BiP/GRP78)
ER Chaperone"]
    DDIT3["DDIT3
(CHOP)
Pro-apoptotic"]
    ATF3["ATF3
Stress Response
Transcription Factor"]
    
    BBB["Blood-Brain
Barrier
Integrity"]
    CLDN5["CLDN5
Claudin-5
Tight Junction"]
    OCLN["OCLN
Occludin
Tight Junction"]
    
    Neuroinflammation["Neuroinflammation
Process"]
    CXCL1["CXCL1
Chemokine
Signaling"]
    IL23A["IL23A
Interleukin-23
Inflammatory"]
    
    ALS["Amyotrophic
Lateral Sclerosis
(ALS)"]
    MS["Multiple
Sclerosis
(MS)"]
    Dementia["Dementia
Cognitive Decline"]
    
    Mitochondria["TOMM20
Mitochondrial
Import"]
    
    XBP1 -->|"activates"| ER_Stress
    XBP1 -->|"activates"| HSPA5
    XBP1 -->|"activates"| DDIT3
    XBP1 -->|"activates"| ATF3
    XBP1 -->|"activates"| Mitochondria
    
    XBP1 -->|"therapeutic_target"| BBB
    XBP1 -->|"therapeutic_target"| CLDN5
    XBP1 -->|"therapeutic_target"| OCLN
    
    XBP1 -->|"therapeutic_target"| CXCL1
    XBP1 -->|"therapeutic_target"| IL23A
    CXCL1 -->|"promotes"| Neuroinflammation
    IL23A -->|"promotes"| Neuroinflammation
    
    ER_Stress -->|"contributes"| ALS
    ER_Stress -->|"contributes"| MS
    ER_Stress -->|"contributes"| Dementia
    
    DDIT3 -->|"promotes"| ALS
    Neuroinflammation -->|"contributes"| MS
    BBB -->|"dysfunction"| Dementia
    
    style XBP1 fill:#006494
    style HSPA5 fill:#1b5e20
    style BBB fill:#1b5e20
    style CLDN5 fill:#1b5e20
    style OCLN fill:#1b5e20
    style ER_Stress fill:#ef5350
    style DDIT3 fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style ATF3 fill:#4a1a6b
    style CXCL1 fill:#4a1a6b
    style IL23A fill:#4a1a6b
    style Mitochondria fill:#4a1a6b
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Dementia fill:#5d4400

Outgoing (154)

Target	Relation	Type	Str
SESTRIN2	upregulates	gene	0.92
Als	activates	disease	0.75
Mitophagy	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Er Stress	activates	pathway	0.70
STING	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
Fibrosis	activates	disease	0.65
Aging	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Carcinoma	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Obesity	interacts_with	disease	0.65
Hepatitis	activates	disease	0.65
Glioblastoma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Cardiovascular	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Obesity	activates	disease	0.65
Tumor	activates	disease	0.65
PDIA6	protects_against	gene	0.60
CXCL2	therapeutic_target	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
GENES	regulates	gene	0.60
Unfolded Protein Response	regulates	pathway	0.60
Autophagy	regulates	pathway	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	activates	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60
Proteostasis	activates	pathway	0.60
Mtor	activates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Er Stress	interacts_with	pathway	0.60
AND	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60

Incoming (107)

Source	Relation	Type	Str
DTG	upregulates	drug	0.85
NLRP3	activates	gene	0.70
APOE4	inhibits	protein	0.70
OPTN	activates	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
DDIT3	activates	gene	0.60
CLDN5	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60
OCLN	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
MBP	activates	gene	0.60
SOX9	activates	gene	0.60
ERN1	activates	gene	0.60
TREM2	activates	gene	0.60
ATF6	activates	gene	0.60
GADD34	activates	gene	0.60
BNIP3	regulates	gene	0.60
CD44	inhibits	gene	0.60
IL12B	activates	gene	0.60
HSPA5	activates	gene	0.60
CXCL2	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
MAP1LC3B	activates	gene	0.60
SREBF1	regulates	gene	0.60
MYO7A	activates	gene	0.60
APOE	regulates	gene	0.60
FOXO3	regulates	gene	0.60
RNA	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
SESTRIN2	activates	gene	0.60
HK2	activates	gene	0.60
PERK	activates	entity	0.60
CYTOKINES	activates	gene	0.60
LC3B	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ROS	activates	gene	0.60
CANCER	activates	gene	0.60
PARKINSON	regulates	gene	0.60
AND	activates	gene	0.60
IL6	therapeutic_target	gene	0.60
ATF4	activates	gene	0.60
PPP1R15A	activates	gene	0.60
IL12B	therapeutic_target	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XBP1 in their description or question text

No additional research found

XBP1

Understanding Entity Pages

Summary

Wiki Pages (10)

XBP1 - X-Box Binding Protein 1

Munc18-1 Protein (STXBP1)

STXBP1 Protein

STXBP1 Encephalopathy

STXBP1 Encephalopathy — Preclinical Gene Therapy Program

STXBP1 — Syntaxin Binding Protein 1

STXBP1

STXBP1 Foundation

XBP1 — X-Box Binding Protein 1

XBP1 Protein