concept

EIF2S1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2S1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

466Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EIF2S1 is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with AD, ALI, Als. Connected to 213 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	EIF2S1
Key Genes/Proteins	ACTIN, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
Related Diseases	AD, ALI, Als, Alzheimer, Alzheimer Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EIF2S1 (eIF2α)

gene · 673 words

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Pathway Diagram

graph TD
    EIF2S1["EIF2S1"]
    EIF2S1 -->|"interacts"| Dementia["Dementia"]
    EIF2S1 -->|"interacts"| Cardiovascular["Cardiovascular"]
    EIF2S1 -->|"interacts"| Als["Als"]
    EIF2S1 -->|"interacts"| Alzheimer["Alzheimer"]
    EIF2S1 -->|"interacts"| Parkinson["Parkinson"]
    EIF2S1 -->|"interacts"| Ms["Ms"]
    EIF2S1 -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    EIF2S1 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    EIF2S1 -->|"interacts"| Ftd["Ftd"]
    CAT["CAT"] -->|"interacts"| EIF2S1
    OPTN["OPTN"] -->|"interacts"| EIF2S1
    DNM1L["DNM1L"] -->|"interacts"| EIF2S1
    CANX["CANX"] -->|"interacts"| EIF2S1
    LGALS3["LGALS3"] -->|"interacts"| EIF2S1
    CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2S1
    G3BP1["G3BP1"] -->|"interacts"| EIF2S1
    PEX3["PEX3"] -->|"interacts"| EIF2S1
    SQSTM1["SQSTM1"] -->|"interacts"| EIF2S1
    BCL2["BCL2"] -->|"interacts"| EIF2S1

Outgoing (250)

Target	Relation	Type	Str
Dementia	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Ischemia	associated_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Ftd	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
FTD	activates	entity	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
HIF	activates	gene	0.60
HIF1	activates	gene	0.60
LC3B	activates	gene	0.60
NIX	activates	gene	0.60
NLR	activates	gene	0.60
ROS	activates	gene	0.60
PKR	activates	gene	0.60
RIPK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60

Incoming (216)

Source	Relation	Type	Str
CATALASE	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
DNM1L	activates	entity	0.60
DRP1	activates	entity	0.60
PARL	interacts_with	gene	0.60
EIF2AK3	activates	entity	0.60
NIX	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
BNIP3	associated_with	gene	0.60
EEF2	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF2S1 in their description or question text

No additional research found