gene

BNIP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BNIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1292Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

BNIP3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 615 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BNIP3
Full Name	BCL2 Interacting Protein 3
Chromosome	10q26.3
Function	is a pro-apoptotic BH3-only protein that plays a dual role in regulating both apoptosis and mitophagy.
Primary Expression	Ubiquitous; high expression in brain, heart, and skeletal muscle
Pathways	Apoptosis, Autophagy, Chaperone, Histone Modification, Lipid Metabolism
UniProt ID	Q12986
NCBI Gene ID	664
Ensembl ID	ENSG00000176171
OMIM	604488
GeneCards	BNIP3
Human Protein Atlas	BNIP3
Associated Diseases	AD, ALI, Als, Alzheimer, brain ischemia
Known Drugs/Compounds	dimethyl fumarate
Interactions	ABCD3, ACETYL-COA, Actin, ADORA2A, AGING, ALS
KG Connections	1292 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BNIP3 — AlphaFold Q12986 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    BNIP3(["BNIP3"])
    Mitophagy("Mitophagy")
    MITOPHAGY(["MITOPHAGY"])
    Autophagy["Autophagy"]
    Als["Als"]
    Ischemia["Ischemia"]
    mitophagy("mitophagy")
    Programmed_Mitophagy("Programmed Mitophagy")
    AUTOPHAGY(["AUTOPHAGY"])
    MITOCHONDRIA(["MITOCHONDRIA"])
    NIX(["NIX"])
    LC3B(["LC3B"])

    BNIP3 -->|"activates"| Mitophagy
    BNIP3 -->|"regulates"| Mitophagy
    MITOPHAGY -->|"regulates"| BNIP3
    MITOPHAGY -->|"activates"| BNIP3
    BNIP3 -->|"activates"| Autophagy
    BNIP3 -->|"activates"| Als
    BNIP3 -->|"regulates"| Ischemia
    BNIP3 -->|"participates in"| mitophagy
    BNIP3 -->|"activates"| mitophagy
    BNIP3 -->|"mediates"| Programmed_Mitophagy
    BNIP3 -->|"activates"| AUTOPHAGY
    BNIP3 -->|"activates"| MITOCHONDRIA
    BNIP3 -->|"regulates"| NIX
    BNIP3 -->|"interacts with"| LC3B
    BNIP3 -->|"involved in"| Mitophagy

    style BNIP3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (949)

Target	Relation	Type	Str
Mitophagy	regulates	pathway	1.00
Mitophagy	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	0.95
Mitophagy	mediates	process	0.95
Ischemia	regulates	disease	0.95
programmed mitophagy	regulates	process	0.90
Programmed Mitophagy	mediates	process	0.90
mitophagy	participates_in	pathway	0.90
autophagy pathway	participates_in	pathway	0.90
mitophagy	activates	phenotype	0.90
NIX	regulates	gene	0.90
MITOCHONDRIA	activates	gene	0.90
AUTOPHAGY	activates	gene	0.90
MITOPHAGY	mediates	process	0.85
Mitophagy	involved_in	process	0.80
autophagy	activates	pathway	0.80
LC3B	interacts_with	protein	0.80
oxidative stress response	participates_in	pathway	0.80
MITOPHAGY	downregulation_by_copper_impairs	process	0.80
WIPI-ATG13 complex	interacts_with	protein	0.80
GENES	activates	gene	0.80
Apoptosis	activates	pathway	0.80
Tumor	activates	disease	0.75
Ischemia	activates	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Cancer	inhibits	disease	0.75
Inflammation	activates	disease	0.75
Als	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cancer	regulates	disease	0.75
Cancer	activates	disease	0.75
PARKIN	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
Mitophagy	biomarker_for	pathway	0.70
Alzheimer's disease	regulates	disease	0.70
NIX	contributes_to	gene	0.70
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.70
MITOCHONDRIA	regulates	gene	0.70
Autophagy	regulates	pathway	0.70
APOPTOSIS	expressed_in	gene	0.70
CANCER	activates	gene	0.70
Mitophagy	contributes_to	pathway	0.70
CANCER	regulates	gene	0.70
Apoptosis	expressed_in	pathway	0.70
neurodegeneration	activates	process	0.70
CANCER	therapeutic_target	gene	0.70
AUTOPHAGY	regulates	gene	0.70
LC3	activates	gene	0.70
ATG7	activates	gene	0.70

Incoming (343)

Source	Relation	Type	Str
MITOPHAGY	regulates	gene	1.00
MITOPHAGY	activates	gene	1.00
Copper	downregulates	compound	0.95
h-2a4e4ad2	targets_gene	hypothesis	0.90
NFKB	downregulates	protein	0.85
SIRT1	upregulates	protein	0.85
Srt2104	upregulates	drug	0.80
FOXO	activates	protein	0.80
HIF1	activates	protein	0.80
HIF1A	activates	protein	0.80
FOXO3	regulates	protein	0.80
NLRP3 inhibition	contributes_to	phenotype	0.80
APOPTOSIS	activates	gene	0.80
ATG	regulates	gene	0.70
MITOPHAGY	contributes_to	gene	0.70
PINK1	regulates	gene	0.70
PINK1	activates	gene	0.70
ischemia	regulates	process	0.70
NIX	regulates	gene	0.70
SIRT1	regulates	gene	0.70
NIX	interacts_with	gene	0.60
NIX	contributes_to	gene	0.60
HIF-1Α	activates	gene	0.60
AND	activates	gene	0.60
BCL-2	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
HIF	activates	gene	0.60
ROS	activates	gene	0.60
AGING	activates	gene	0.60
CYTOKINES	activates	gene	0.60
TNF-Α	activates	gene	0.60
GENES	regulates	gene	0.60
AUTOPHAGY-RELATED GENES	regulates	gene	0.60
DNA	interacts_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
BCL-2	interacts_with	gene	0.60
HIF-1Α	therapeutic_target	gene	0.60
HIF	therapeutic_target	gene	0.60
BCL-2	inhibits	gene	0.60
NAD	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
SESTRIN2	interacts_with	gene	0.60
ATP	inhibits	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
CALCOCO2	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Mitochondrial transfer between neurons and glia?

closed · Rounds: 4 · Score: 0.71 · 2026-04-12

Analysis question not specified

closed · Rounds: 4 · Score: 0.81 · 2026-04-06