gene

BCL2L11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2L11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

462Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BCL2L11 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, therapeutic target. Associated with AD, ALI, Als. Connected to 190 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BCL2L11
Full Name	BCL2 Like 11 (BIM)
Chromosome	2q13
Function	is a potent pro-apoptotic BH3-only protein that belongs to the Bcl-2 family.
Primary Expression	Ubiquitous; high expression in neuronal tissues
Pathways	MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway, autophagy pathway
UniProt ID	O43521
NCBI Gene ID	10018
Ensembl ID	ENSG00000113194
OMIM	603677
GeneCards	BCL2L11
Human Protein Atlas	BCL2L11
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Interactions	ABCD3, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AMPK
KG Connections	462 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BCL2L11 — AlphaFold O43521 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BCL2L11 Gene

gene · 579 words

→

BCL2L11 Protein — BIM

protein · 587 words

→

Pathway Diagram

flowchart TD
    FOXO["FOXO
Transcription Factor"] -->|"activates"| BCL2L11["BCL2L11 (BIM)
Pro-apoptotic Protein"]
    
    BCL2L11 --> Apoptosis["Neuronal Apoptosis
Cell Death"]
    
    PTEN["PTEN
Tumor Suppressor"] -->|"interacts_with"| BCL2L11
    MAPK8["MAPK8 (JNK)
Stress Kinase"] -->|"activates"| BCL2L11
    
    BCL2L11 -->|"interacts_with"| BNIP3["BNIP3
Mitochondrial Death Protein"]
    BCL2L11 -->|"interacts_with"| CHOP["CHOP/DDIT3
ER Stress Response"]
    
    ER_Stress["ER Stress
Protein Misfolding"] --> CHOP
    Oxidative_Stress["Oxidative Stress
ROS Production"] --> MAPK8
    
    BCL2L11 -->|"interacts_with"| DRP1["DRP1
Mitochondrial Fission"]
    DRP1 --> Mito_Dysfunction["Mitochondrial
Dysfunction"]
    
    BCL2L11 -->|"interacts_with"| BECN1["BECN1
Autophagy Regulator"]
    BECN1 --> Autophagy["Impaired Autophagy
Protein Clearance"]
    
    Apoptosis --> Alzheimer["Alzheimer's
Disease"]
    Apoptosis --> Parkinson["Parkinson's
Disease"]
    Apoptosis --> ALS["Amyotrophic Lateral
Sclerosis"]
    Apoptosis --> FTD["Frontotemporal
Dementia"]
    
    Mito_Dysfunction --> Neurodegeneration["Neurodegeneration
Process"]
    Autophagy --> Neurodegeneration
    
    style BCL2L11 fill:#006494
    style FOXO fill:#4a1a6b
    style PTEN fill:#4a1a6b
    style MAPK8 fill:#4a1a6b
    style BECN1 fill:#1b5e20
    style Apoptosis fill:#ef5350
    style ER_Stress fill:#ef5350
    style Oxidative_Stress fill:#ef5350
    style Mito_Dysfunction fill:#ef5350
    style Autophagy fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style FTD fill:#5d4400

Outgoing (294)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
miRNAs	targets	mirna	0.80
organelle-specific autophagy	modulates	process	0.75
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
PHB2	activates	gene	0.60
DEMENTIA	interacts_with	gene	0.60
RB1	activates	gene	0.60
frontotemporal	associated_with	disease	0.60
NIX	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
BCL2L13	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
Alzheimer	associated_with	disease	0.60
dementia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Mapk	interacts_with	pathway	0.60
JNK	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60

Incoming (168)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
FOXO	activates	protein	0.80
AMPK	activates	entity	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ALS	activates	entity	0.60
ABCD3	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
ATG	activates	gene	0.60
ATP	activates	gene	0.60
EIF2S1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BCL2L11 in their description or question text

No additional research found