gene

OPTN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPTN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2650Connections

4Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

OPTN is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 1179 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OPTN
Full Name	Optineurin
Chromosome	10p13
Protein Type	Adaptor Protein
Function	is a 66 kDa coiled-coil domain-containing protein encoded by the OPTN gene on chromosome 10p13.
Primary Expression	Motor cortex, Spinal cord, Retina, Brain
Molecular Weight	66 kDa
Amino Acids	577 aa
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Immune Response
UniProt ID	Q96CV9
NCBI Gene ID	10133
Ensembl ID	ENSG00000123240
OMIM	602432
GeneCards	OPTN
Human Protein Atlas	OPTN
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	DEFERIPRONE, dimethyl fumarate, loganin, rapamycin, RAPAMYCIN
Interactions	ABCD3, ABP, ACAT1, ACHE, ACSL4, ACTB
SciDEX Hypotheses	OPTN/TBK1 mutations create selective vulnerability
KG Connections	2650 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OPTN — AlphaFold Q96CV9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OPTN["OPTN"] -->|"associated"| ALS["ALS"]
    OPTN["OPTN"] -.->|"inhibits"| RIPK1["RIPK1"]
    OPTN["OPTN"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    OPTN["OPTN"] -->|"interacts"| Dementia["Dementia"]
    OPTN["OPTN"] -->|"interacts"| Als["Als"]
    OPTN["OPTN"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    ACTB["ACTB"] -->|"interacts"| OPTN["OPTN"]
    CAT["CAT"] -->|"interacts"| OPTN["OPTN"]
    MYO7A["MYO7A"] -->|"activates"| OPTN["OPTN"]
    MAP1LC3B["MAP1LC3B"] -->|"activates"| OPTN["OPTN"]
    style OPTN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1484)

Target	Relation	Type	Str
Autophagy	activates	pathway	1.00
Neurodegeneration	activates	disease	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Als	interacts_with	disease	1.00
Als	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Mitophagy	activates	pathway	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
Autophagy	inhibits	pathway	1.00
Nf-Κb	regulates	pathway	1.00
Anterograde Axonal Mitochondrial Transport	regulates	process	0.95
Ubiquitin-Dependent Mitophagy	mediates	process	0.95
mitophagy	initiates	process	0.95
Lipophagy	involved_in	process	0.95
PINK1/Parkin Mitophagy	associated_with	process	0.95
Mitophagy	mediates	process	0.95
TRAK1	interacts_with	protein	0.95
Drug-Induced Liver Injury	protects_against	disease	0.95
Tumor	activates	disease	0.95
ALS	risk_factor_for	disease	0.95
glaucoma	risk_factor_for	disease	0.95
normal tension glaucoma	risk_factor_for	disease	0.95
Glaucoma	associated_with	disease	0.95
inflammatory signalling	regulates	pathway	0.95
vesicle trafficking	modulates	process	0.95
Als	regulates	disease	0.95
glaucoma	associated_with	disease	0.95
Axonal Mitochondrial Transport	mediates	process	0.95
NLRP3 degradation	promotes	process	0.95
Dementia	associated_with	disease	0.95
Axonal Mitochondria Delivery	associated_with	process	0.95
UBIQUITIN	binds_to	entity	0.95
Normal Tension Glaucoma	associated_with	disease	0.95
TRAK1/KIF5B	interacts_with	protein	0.95
diabetic cardiomyopathy	therapeutic_target	disease	0.93
ALS	associated_with	disease	0.92
endoplasmic reticulum stress	inhibits	process	0.92
Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.92
mitochondrial homeostasis	maintains	process	0.92
bone metabolism	regulates	process	0.92
polyubiquitin	binds_to	protein	0.92
Multisystem Proteinopathy	causes	disease	0.90
glycophagy	inhibits	process	0.90
motor neuron degeneration	causes	process	0.90
UBIQUITIN	binds	gene	0.90
GCDH	degrades	gene	0.90
osteogenic differentiation	promotes	process	0.90
osteoclastogenesis	inhibits	process	0.90

Incoming (1166)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
UBIQUITIN	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
PINK1	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
SQSTM1	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
USP25	interacts_with	protein	0.95
SINTBAD	inhibits	protein	0.90
NAP1	inhibits	protein	0.90
MAP3K1	interacts_with	protein	0.90
TBK1	binds	protein	0.90
KENNY	associated_with	gene	0.90
NDP52	activates	gene	0.90
MITOCHONDRIA	activates	gene	0.90
P62	activates	gene	0.90
P62	interacts_with	gene	0.90
AUTOPHAGY	inhibits	gene	0.90
TNF	activates	gene	0.90
FLNA	interacts_with	gene	0.87
CKLF	upregulates	protein	0.85
AGEs	inhibits	protein	0.85
TBK1	phosphorylates	protein	0.85
GSK3B	phosphorylates	gene	0.83
RAB10	interacts_with	protein	0.82
VCP	stabilizes	protein	0.82
FOXO1	regulates	gene	0.81
CKLF	contributes_to	protein	0.80
CALCOCO2	regulates	gene	0.80
AGING	associated_with	phenotype	0.80
NLR	regulates	gene	0.80
FIP200	regulates	gene	0.80
VCP	interacts_with_to_stabilize_BECN1	protein	0.80
MAP1LC3B	regulates	gene	0.80
ALS	activates	disease	0.80
MITOCHONDRIA	associated_with	gene	0.80
TBK1	regulates	protein	0.80
PTEN	activates	gene	0.80
OXIDATIVE STRESS	activates	gene	0.80
ROS	activates	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
ALZHEIMER	activates	disease	0.80
NBR1	associated_with	gene	0.80
MITOPHAGY	interacts_with	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
NF-ΚB	regulates	gene	0.80
UBIQUITIN	interacts_with	gene	0.80
ALS	causes	gene	0.80

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle	0.772	neurodegeneration	How do different organelle-specific auto
OPTN/TBK1 mutations create selective vulnerability by blocki	0.670	neurodegeneration	What are the neuron-specific effects of
ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascad	0.648	neurodegeneration	How do pathological stress granules in n
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

OPTN

Understanding Entity Pages

Summary

Wiki Pages (5)

OPTN — Optineurin

OPTN Protein (Optineurin)

OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal Chain

OPTN Protein (Optineurin)

OPTN Protein (Optineurin)

Pathway Diagram

Outgoing (1484)

Incoming (1166)

Targeting Hypotheses (4)

Mentioning Analyses (1)

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

Experiments (0)

Related Papers (0)

Debates (1)

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d