gene

BCL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2860Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

B-cell lymphoma 2 - anti-apoptotic protein critical for neuronal survival in neurodegeneration

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🧬 Gene Info

Gene Symbol	BCL2
Aliases	B-cell lymphoma 2
Protein Family	BCL-2 family (anti-apoptotic subfamily)
Function	Direct BAX/BAK inhibition
Molecular Weight	26 kDa
Pathways	Akt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain
UniProt ID	P10415
GeneCards	BCL2
Human Protein Atlas	BCL2
BH3 domain	Required for interaction with pro-apoptotic family members
Transmembrane domain	Anchors BCL2 to the outer mitochondrial membrane, ER, and nuclear envelope
BH1 domain	Forms part of the hydrophobic pocket that binds BH3 domains
BH2 domain	Contributes to the binding interface for pro-apoptotic proteins
N-terminal flexible region	Contains regulatory sequences
Phosphorylation	BCL2 is phosphorylated on multiple serine/threonine residues
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Abt263, ABT263, ABT-737, Adcs, berberine, BERBERINE
Interactions	ABCD3, ABP, ACETYL-COA, ACHE, Actin, AD
KG Connections	2857 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BCL2 — AlphaFold P10415 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BCL2["BCL2"] -->|"expressed in"| MITOCHONDRIA["MITOCHONDRIA"]
    BCL2["BCL2"] -.->|"inhibits"| BECN1["BECN1"]
    BCL2["BCL2"] -->|"interacts"| Dementia["Dementia"]
    BCL2["BCL2"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    BCL2["BCL2"] -->|"interacts"| Als["Als"]
    BCL2["BCL2"] -->|"interacts"| Alzheimer["Alzheimer"]
    STAT3["STAT3"] -->|"regulates"| BCL2["BCL2"]
    BMAL1["BMAL1"] -->|"regulates"| BCL2["BCL2"]
    CAT["CAT"] -->|"interacts"| BCL2["BCL2"]
    OPTN["OPTN"] -->|"interacts"| BCL2["BCL2"]
    style BCL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1924)

Target	Relation	Type	Str
Tumor	inhibits	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
Als	regulates	disease	1.00
Cancer	regulates	disease	1.00
CASP3	associated_with	gene	1.00
Apoptosis	activates	pathway	1.00
Apoptosis	therapeutic_target	pathway	1.00
Als	therapeutic_target	disease	1.00
Leukemia	inhibits	disease	1.00
Als	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Tumor	therapeutic_target	disease	1.00
Leukemia	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Autophagy	activates	pathway	1.00
Lymphoma	activates	disease	1.00
Apoptosis	inhibits	pathway	1.00
CANCER	inhibits	gene	1.00
Cancer	inhibits	disease	1.00
AKT	therapeutic_target	gene	1.00
Oxidative Stress	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
Intrinsic Apoptosis	regulates	pathway	0.98
AMBRA1	associated_with	protein	0.95
chronic lymphocytic leukaemia	therapeutic_target	disease	0.95
cancer	therapeutic_target	disease	0.95
chronic lymphocytic leukemia	therapeutic_target	disease	0.95
Cytochrome C Release	regulates	process	0.95
Cancer	associated_with	disease	0.95
Lymphoma	associated_with	disease	0.95
Als	inhibits	disease	0.95
cell survival	regulates	process	0.95
cytochrome c release	regulates	process	0.95
Cytochrome C	regulates	protein	0.95
acute myeloid leukemia	therapeutic_target	disease	0.92
acute myeloid leukemia	biomarker_for	disease	0.92
cancer cell death	inhibits	process	0.90
intrinsic apoptosis pathway	upstream_of	pathway	0.90
BECLIN1	associated_with	protein	0.90
diffuse large B-cell lymphoma	associated_with	disease	0.90
proapoptotic proteins	interacts_with	protein	0.90
Macroautophagy	inhibits	process	0.90
IP3R	binds	protein	0.90
autophagy pathway	participates_in	pathway	0.90
BECN1	associated_with	protein	0.90
apoptosis	inhibits	phenotype	0.90
mantle cell lymphoma	therapeutic_target	disease	0.90
apoptosis	regulates	phenotype	0.90
Mitochondrial Outer Membrane Permeabilization	causes	process	0.90

Incoming (936)

Source	Relation	Type	Str
APOPTOSIS	associated_with	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
TP53	interacts_with	protein	1.00
venetoclax	inhibits	drug	0.95
T3 (triiodothyronine)	increases	drug	0.95
ABT263	inhibits	drug	0.95
Cyclosporine A	downregulates	drug	0.92
HB68	downregulates	compound	0.92
HB147	downregulates	compound	0.92
BH3-Mimetics	targets	compound	0.90
CTSG	inhibits	protein	0.90
R-phycoerythrin	associated_with	drug	0.90
Akt/mTOR pathway	activates	pathway	0.90
Venetoclax	inhibits	drug	0.90
gallic acid	associated_with	drug	0.90
Bh3-Mimetics	targets	compound	0.90
Rotenone	downregulates	compound	0.90
sonrotoclax	binds_to	drug	0.90
venetoclax	binds_to	drug	0.90
cardamom nanoemulsion	downregulates	compound	0.90
Abt263	inhibits	drug	0.90
STAT3	activates	gene	0.90
OXIDATIVE STRESS	activates	gene	0.90
PI3K	therapeutic_target	gene	0.90
PI3K	regulates	protein	0.90
PI3K	activates	gene	0.90
JAK2/STAT3 Signaling Pathway	upregulates	pathway	0.88
melamine	downregulates	compound	0.87
BCL-xL	coexpressed_with	protein	0.87
MCL1	coexpressed_with	protein	0.87
Oxidative Stress	downregulates	process	0.85
TP53	associated_with	protein	0.85
miR-195	downregulates	gene	0.85
AKR1B10	regulates	gene	0.85
HB147	targets	compound	0.85
Nomilin	binds	compound	0.85
BPF	binds_to	drug	0.85
LYPLAL1-DT	activates	gene	0.85
Bisphenol F	binds	compound	0.85
sonrotoclax	inhibits	drug	0.85
Adcs	targets	compound	0.85
BMAL1	upregulates	gene	0.85
lisaftoclax	inhibits	drug	0.85
Protacs	targets	compound	0.85
SQDS	upregulates	drug	0.85
BAX	associated_with	gene	0.82
nomilin	binds_to	drug	0.80
TP53	regulates	gene	0.80
STAT3	regulates	protein	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BCL2 in their description or question text

No additional research found

BCL2

Understanding Entity Pages

Summary

Wiki Pages (17)

BCL2 Gene

BOK — BCL2 Family Ovarian Killer

BBC3 — BCL2 Binding Component 3 (PUMA)

BCL2L2 Gene

BCL2L12 Gene

BCL2 (B-Cell Lymphoma 2)

BCL2A1 Protein

BNIP3L — BCL2 Interacting Protein 3 Like (NIX)

BCL2L10

BCL2A1 Gene

BCL2L1 Gene

BCL2L13

BCL2L1 Protein — BCL-XL

BCL2L11 Protein — BIM

BAD Gene - BCL2-Associated Agonist of Cell Death

BCL2L11 Gene

BCL2 Protein