gene

RIPK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIPK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1530Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RIPK3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 632 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RIPK3
Function	Necrosome formation: RHIM-RHIM interactions recruit RIPK3 to activated RIPK1; RIPK1 undergoes conformational change exposing its RHIM
Primary Expression	Restrictive — immune cells, neurons, some epithelial cells
Molecular Weight	56.8 kDa (527 amino acids)
Amino Acids	527 aa
Pathways	Apoptosis, Autophagy, Dna Methylation, Ferroptosis, Immune Response
GeneCards	RIPK3
Human Protein Atlas	RIPK3
Associated Diseases	AD, ALI, Als, Alzheimer
Known Drugs/Compounds	Adeno-Associated Virus, HSYA, metformin, Mitochondrial ROS, Ponicidin, rapamycin
Interactions	ABCD3, ACOD1, ACSL4, Actin, AD, ADAR1
KG Connections	1530 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    RIPK3(["RIPK3"])
    Necroptosis["Necroptosis"]
    Inflammation["Inflammation"]
    Cell_Death("Cell Death")
    MLKL(["MLKL"])
    INFLAMMATION(["INFLAMMATION"])
    Cancer["Cancer"]
    RIPK1(["RIPK1"])
    Apoptosis["Apoptosis"]
    Pyroptosis["Pyroptosis"]
    Inflammasome["Inflammasome"]
    TNF(["TNF"])

    RIPK3 -->|"regulates"| Necroptosis
    RIPK3 -->|"activates"| Inflammation
    RIPK3 -->|"regulates"| Cell_Death
    RIPK3 -->|"activates"| Necroptosis
    RIPK3 -->|"regulates"| MLKL
    INFLAMMATION -->|"activates"| RIPK3
    RIPK3 -->|"therapeutic target"| Cancer
    RIPK3 -->|"regulates"| RIPK1
    RIPK3 -->|"activates"| Apoptosis
    RIPK3 -->|"therapeutic target"| Pyroptosis
    RIPK3 -->|"therapeutic target"| Apoptosis
    RIPK3 -->|"regulates"| Apoptosis
    RIPK3 -->|"activates"| Inflammasome
    RIPK3 -->|"therapeutic target"| Necroptosis
    TNF -->|"activates"| RIPK3

    style RIPK3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (754)

Target	Relation	Type	Str
Necroptosis	regulates	pathway	1.00
PANoptosis	component_of	process	0.95
Necroptosis	mediates	process	0.95
Antiviral gene transcription	activates	process	0.95
Necroptosis	component_of	pathway	0.95
Inflammation	activates	disease	0.95
Neuron	expressed_in	entity	0.90
PANoptosis	regulates	process	0.90
NF-κB	activates	protein	0.90
Axonal Degeneration	mediates	process	0.90
Necroptosis	associated_with	process	0.90
Necroinflammation	involved_in	process	0.90
necroptosis	participates_in	pathway	0.90
Panoptosis	activates	process	0.90
TRIF	interacts_with	protein	0.90
MLKL	phosphorylates	protein	0.90
tumor cell death	associated_with	phenotype	0.90
Cell Death	regulates	process	0.90
Necroptosis	activates	pathway	0.90
MLKL	regulates	gene	0.90
Lytic Cell Death	mediates	process	0.88
Proinflammatory Mediators	upregulates	process	0.88
myocardial inflammation	promotes	process	0.88
NFKB	activates	protein	0.87
Antitumor Immunity	contributes_to	process	0.85
IL-6	upstream_of	protein	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
Cancer	therapeutic_target	disease	0.85
PANoptosis	mediates	process	0.85
Lytic Cell Death	associated_with	process	0.85
DAMPs	associated_with	compound	0.85
Cytokines	regulates	protein	0.85
oxidative stress response	participates_in	pathway	0.80
neuroinflammation	activates	disease	0.80
antitumor immunity	potentiates	process	0.80
Pyroptosis	therapeutic_target	pathway	0.80
Inflammasome	activates	pathway	0.80
Apoptosis	activates	pathway	0.80
Apoptosis	therapeutic_target	pathway	0.80
Apoptosis	regulates	pathway	0.80
Necroptosis	therapeutic_target	pathway	0.80
RIPK1	regulates	gene	0.80
Als	therapeutic_target	disease	0.75
Als	activates	disease	0.75
Als	regulates	disease	0.75
Tumor	activates	disease	0.75
Amyotrophic Lateral Sclerosis	regulates	disease	0.75
Cancer	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Stevens-Johnson Syndrome	biomarker_for	disease	0.75

Incoming (776)

Source	Relation	Type	Str
PARP12	associated_with	gene	0.90
INFLAMMATION	activates	gene	0.90
Mitochondrial ROS	activates	compound	0.85
adeno-associated viruses	associated_with	drug	0.85
HSYA	binds	compound	0.85
Metformin	inhibits	gene	0.80
Ponicidin	inhibits	compound	0.80
THSG	inhibits	compound	0.80
EPILEPSY	associated_with	gene	0.80
Adeno-Associated Virus	targets	drug	0.80
TNF	activates	gene	0.80
APOPTOSIS	activates	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
NECROPTOSIS	activates	pathway	0.70
LRRK2	interacts_with	gene	0.70
NFKB	activates	gene	0.70
NEURONS	activates	cell_type	0.70
MICROGLIA	markers	cell_type	0.70
MLKL	causes	gene	0.70
NECROPTOSIS	mediates	pathway	0.70
MLKL	protects_against	gene	0.70
MULTIPLE SCLEROSIS	associated_with	disease	0.70
ASTROCYTE	activates	cell_type	0.70
NEURONS	interacts_with	cell_type	0.70
RIPK1	expressed_in	gene	0.70
NECROPTOSIS	markers	pathway	0.70
NECROPTOSIS	regulates	pathway	0.70
NLR	activates	gene	0.70
ATG	regulates	gene	0.70
NLR	regulates	gene	0.70
ATG	activates	gene	0.70
PYROPTOSIS	therapeutic_target	gene	0.70
INFLAMMATION	regulates	gene	0.70
PYROPTOSIS	activates	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.70
APOPTOSIS	regulates	gene	0.70
ERN1	regulates	gene	0.70
PYROPTOSIS	regulates	gene	0.70
RIPK1	associated_with	gene	0.70
BECN1	regulates	gene	0.70
NLRP3	regulates	gene	0.70
LC3	regulates	gene	0.70
RIPK1	regulates	gene	0.70
BAX	activates	gene	0.70
DENDRITIC CELL	activates	cell_type	0.65
ATP	activates	gene	0.65
NEURONS	causes	cell_type	0.65
PYCARD	activates	gene	0.65
MTOR	activates	gene	0.65
PI3K	activates	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity