concept

RETREG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RETREG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

339Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RETREG1 is a concept in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 158 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	RETREG1
Key Genes/Proteins	ABCD3, Actin, AKT, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
Related Diseases	AD, ALI, Als, ALS, Alzheimer
Related Pathways	Akt

Pathway Diagram

graph TD
    RETREG1["RETREG1"]
    RETREG1 -->|"interacts"| Alzheimer["Alzheimer"]
    RETREG1 -->|"interacts"| ALS["ALS"]
    RETREG1 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    RETREG1 -->|"interacts"| Dementia["Dementia"]
    RETREG1 -->|"interacts"| Cardiovascular["Cardiovascular"]
    RETREG1 -->|"interacts"| Parkinson["Parkinson"]
    RETREG1 -->|"interacts"| AUTOPHAGY["AUTOPHAGY"]
    RETREG1 -->|"interacts"| STING1["STING1"]
    RETREG1 -->|"interacts"| LC3["LC3"]
    RETREG1 -->|"interacts"| MAPK8["MAPK8"]
    SQSTM1["SQSTM1"] -->|"activates"| RETREG1
    BCL2L11["BCL2L11"] -->|"interacts"| RETREG1
    DNA["DNA"] -->|"interacts"| RETREG1
    NIX["NIX"] -->|"interacts"| RETREG1
    HIF1["HIF1"] -->|"interacts"| RETREG1
    RB1["RB1"] -->|"interacts"| RETREG1
    NLRP3["NLRP3"] -->|"interacts"| RETREG1
    PARKINSON["PARKINSON"] -->|"interacts"| RETREG1
    FMR1["FMR1"] -->|"interacts"| RETREG1
    RB1CC1["RB1CC1"] -->|"interacts"| RETREG1

Outgoing (154)

Target	Relation	Type	Str
Reticulophagy	mediates	process	0.90
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Dementia	interacts_with	disease	0.65
Als	activates	disease	0.65
Carcinoma	activates	disease	0.65
HIF	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60

Incoming (185)

Source	Relation	Type	Str
USP20	associated_with	enzyme	0.95
SQSTM1	activates	gene	0.80
DNA	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity