gene

EIF2AK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2AK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

856Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

Page for EIF2AK3 - Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3

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🧬 Gene Info

Gene Symbol	EIF2AK3
Full Name	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3
Aliases	Page for EIF2AK3
Chromosome	2p22.2
Protein Type	Kinase
Function	EIF2AK3 (also known as PERK or EIF2AK1) is an ER transmembrane kinase that initiates the integrated stress response (ISR).
Primary Expression	neurons and glia, with activation in response to ER stress
Molecular Weight	165 kDa
Amino Acids	1448 aa
Pathways	APOPTOSIS, Akt, Apoptosis, Wnt
UniProt ID	[Q9BXJ6](https://www.uniprot.org/uniprot/Q9BXJ6)
Ensembl ID	ENSG00000168269
OMIM	604032
GeneCards	EIF2AK3
Human Protein Atlas	EIF2AK3
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, ADSL, AKT, AKT1
KG Connections	855 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

EIF2AK3 - Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3

gene · 703 words

→

EIF2AK3 Protein (PERK)

protein · 1678 words

→

Pathway Diagram

graph TD
    A["ER Stress"] -->|"activates"| B["EIF2AK3/PERK"]
    B -->|"phosphorylates"| C["EIF2S1/eIF2alpha"]
    C -->|"inhibits"| D["General Translation"]
    C -->|"promotes"| E["ATF4"]
    E -->|"activates"| F["CHOP/DDIT3"]
    F -->|"triggers"| G["Apoptosis"]
    B -->|"interacts with"| H["PRKN"]
    B -->|"interacts with"| I["BCL2L11/BIM"]
    I -->|"promotes"| G
    B -->|"interacts with"| J["BNIP3"]
    J -->|"promotes"| G
    F -->|"leads to"| K["Neurodegeneration"]
    G -->|"contributes to"| K
    H -->|"modulates"| L["Mitochondrial Quality"]
    L -->|"dysfunction leads to"| K

Outgoing (563)

Target	Relation	Type	Str
EIF2AK3	encodes	protein	0.00
Endoplasmic Reticulum Stress	activates	process	0.90
ERN1	regulates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
Autophagy	activates	pathway	0.80
AUTOPHAGY	activates	gene	0.80
autophagy	activates	process	0.80
Als	activates	disease	0.75
ER stress response	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
necroptosis	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
ROS	activates	gene	0.70
NLR	activates	gene	0.70
MAPK signaling	participates_in	pathway	0.70
ROS	regulates	gene	0.70
NLR	regulates	gene	0.70
neural stem cells	activates	cell_type	0.70
RB1	activates	gene	0.70
MTORC1	regulates	gene	0.70
neural stem cells	regulates	cell_type	0.70
NBR1	regulates	gene	0.70
OPTN	regulates	gene	0.70
Er Stress	activates	pathway	0.70
LC3	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
STING1	regulates	gene	0.70
FIP200	regulates	gene	0.70
RB1	regulates	gene	0.70
JNK	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
Atherosclerosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Fibrosis	regulates	disease	0.65
ALS	regulates	disease	0.65
Ftd	interacts_with	disease	0.65
Osteoarthritis	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Cardiovascular	activates	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65

Incoming (293)

Source	Relation	Type	Str
EIF2AK3	encodes	gene	0.00
Endoplasmic Reticulum Stress	activates	process	0.90
ERN1	activates	gene	0.70
DNA	activates	gene	0.70
BECN1	activates	gene	0.70
DDIT3	regulates	gene	0.70
DNA	regulates	gene	0.70
ERS	activates	pathway	0.64
ATG	activates	gene	0.60
ATP	activates	gene	0.60
BIM	activates	gene	0.60
DRP1	interacts_with	gene	0.60
AND	activates	gene	0.60
AKT1S1	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
GCN2	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
AKT1	regulates	gene	0.60
DNM1L	activates	entity	0.60
PIK3C3	activates	gene	0.60
YWHAG	activates	gene	0.60
SEL1L	activates	gene	0.60
TIMM17B	activates	gene	0.60
DISC1	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
PERK	activates	gene	0.60
TNF	activates	gene	0.60
ATG5	activates	gene	0.60
IL1B	activates	gene	0.60
IL6	activates	gene	0.60
GSK3B	activates	gene	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
MITOPHAGY	associated_with	gene	0.60
RAS	interacts_with	gene	0.60
rapamycin	targets	drug	0.60
EGFR	regulates	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60