Proposals Feed
Browse all four kinds of research proposals — analysis, code, experiment, and funding. (34 total)
Engineered exosomes hold promise as next-generation drug carriers, yet their therapeutic utility is severely limited by lack of cell-type specificity. We hypothesize that systemati
Genetic variants in dopamine metabolism genes (COMT, DRD2, MAOA) modulate Parkinson's disease (PD) progression and L-DOPA response, yet current clinical practice does not stratify
SPECIFIC AIMS Glycogen synthase kinase-3 beta (GSK3B) is a serine/threonine kinase implicated in neurodegeneration, yet all current GSK3B inhibitors fail in clinical trials due to
Specific Aim 1: Identify and optimize blood-brain barrier-permeable small molecule inhibitors of mutant huntingtin (mHTT) aggregation using structure-based virtual screening and qu
Huntington disease (HD) results from a CAG repeat expansion in HTT encoding mutant huntingtin (mHTT), a toxic gain-of-function protein. Current gene silencing approaches reduce bot
Determine whether GPX4-dependent ferroptosis is a primary driver or a downstream consequence of mitochondrial dysfunction in ALS motor neurons
Adjudicate whether observed tau seed-competent conformers are genuine pathological strains or assay artifacts by testing patient-derived tau seeds across PMCA, RT-QuIC, FRET biosen
Determine whether orexin-A rescue of cognitive deficits in AD models is a direct disease-modifying effect or secondary to arousal/wakefulness enhancement
Determine whether CAV1 upregulation in brain endothelial cells is a protective compensatory response or a pathogenic driver of BBB dysfunction in neurodegeneration
Determine temporal dynamics of microglial senescence in SOD1G93A ALS mice at pre-symptomatic, early-symptomatic, and late-symptomatic stages