gene

PARKINSON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARKINSON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9153Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

PARKINSON is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 2646 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PARKINSON
Sample Size	4,018 whole-genome sequencing (WGS) data of blood samples
Cohorts	Two independent PD cohorts for validation
Analytical Pipeline	Kraken 2 and Bracken software with PlusPF database for microbial annotation
Validation	Population-based cross-cohort filtration process with resampling validation
Motor dysfunction	Specific bacterial species showed association with motor symptom severity
Cognitive impairment	Certain signatures correlated with cognitive decline in PD patients
Associated Diseases	Addiction, aging, Als, Alzheimer
Known Drugs/Compounds	LEVODOPA, RAPAMYCIN, RESVERATROL
Interactions	6-OHDA, AADC, ABCB1, ABCD3, ACETYL-COA, ACHE
KG Connections	5660 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Blood Microbial Signatures in Parkinson's Disease

biomarker · 3060 words

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PARKINSON

entity · 667 words

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Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        PARKINSON["PARKINSON"] -->|"associated with"| ALS["ALS"]
        PARKINSON["PARKINSON"] -->|"associated with"| Parkinson["Parkinson"]
        PARKINSON["PARKINSON"] -->|"associated with"| CANCER["CANCER"]
        PARKINSON["PARKINSON"] -->|"associated with"| AGING["AGING"]
        PARKINSON["PARKINSON"] -->|"associated with"| Aging["Aging"]
        PARKINSON["PARKINSON"] -->|"associated with"| Alzheimer["Alzheimer"]
        PARKINSON["PARKINSON"] -->|"associated with"| Cancer["Cancer"]
        PARKINSON["PARKINSON"] -->|"associated with"| NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
        PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated with"| PARKINSON["PARKINSON"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| PARKINSON["PARKINSON"]
        APOPTOSIS["APOPTOSIS"] -->|"associated with"| PARKINSON["PARKINSON"]
    end
    subgraph Interactions["Interactions"]
        PARKINSON["PARKINSON"] -->|"interacts with"| Parkinson_1["Parkinson"]
    end
    subgraph Signaling["Signaling"]
        PARKINSON_S_DISEASE_2["PARKINSON'S DISEASE"] -.->|"inhibits"| PARKINSON["PARKINSON"]
        PARKINSON_S_DISEASE_3["PARKINSON'S DISEASE"] -->|"regulates"| PARKINSON["PARKINSON"]
        PARKINSON_S_DISEASE_4["PARKINSON'S DISEASE"] -->|"activates"| PARKINSON["PARKINSON"]
    end
    style PARKINSON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ALS fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Parkinson_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style CANCER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AGING fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURODEGENERATIVE_DISEASES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PARKINSON_S_DISEASE_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PARKINSON_S_DISEASE_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PARKINSON_S_DISEASE_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (4112)

Target	Relation	Type	Str
DEMENTIA	associated_with	gene	1.00
Infection	associated_with	disease	1.00
Oxidative Stress	associated_with	pathway	1.00
Dementia	associated_with	disease	1.00
STROKE	associated_with	gene	1.00
Stroke	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Aging	associated_with	disease	1.00
Dementia	associated_with	disease	1.00
Als	associated_with	disease	1.00
Mitochondrial Function	associated_with	pathway	1.00
Oxidative Stress	associated_with	pathway	1.00
Depression	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Aging	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
UBIQUITIN	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
Neuroinflammation	associated_with	disease	1.00
Apoptosis	associated_with	pathway	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
NEURON	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
Stroke	associated_with	disease	1.00
PARKINSON'S DISEASE	targets	gene	1.00
GENES	associated_with	gene	1.00
Parkinson	associated_with	disease	1.00
ALPHA-SYNUCLEIN	associated_with	gene	1.00
Als	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Huntington	associated_with	disease	1.00
INFLAMMATION	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
NEURODEGENERATIVE DISORDERS	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
Mitophagy	associated_with	pathway	1.00
Alzheimer	associated_with	disease	1.00
Multiple Sclerosis	associated_with	disease	1.00
Mitophagy	associated_with	pathway	1.00
Neuroinflammation	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Autophagy	associated_with	pathway	1.00
ALS	associated_with	disease	1.00
Multiple Sclerosis	associated_with	disease	1.00
MITOCHONDRIA	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00

Incoming (5041)

Source	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
GENES	therapeutic_target	gene	1.00
Cancer	associated_with	disease	1.00
GENES	activates	gene	1.00
Neuroinflammation	associated_with	disease	1.00
GENES	regulates	gene	1.00
ALPHA-SYNUCLEIN	associated_with	gene	1.00
NRF2	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
Infection	associated_with	disease	1.00
NEURODEGENERATION	associated_with	gene	1.00
DEPRESSION	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
OXIDATIVE STRESS	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
HUNTINGTON'S DISEASE	associated_with	gene	1.00
MITOPHAGY	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
Huntington	associated_with	disease	1.00
PARKINSON	associated_with	gene	1.00
LRRK2	associated_with	gene	1.00
CANCER	associated_with	gene	1.00
MICROGLIA	associated_with	gene	1.00
STROKE	associated_with	gene	1.00
GENES	associated_with	gene	1.00
PARKIN	associated_with	gene	1.00
OXIDATIVE STRESS	associated_with	gene	1.00
AGING	associated_with	gene	1.00
HUNTINGTON	associated_with	gene	1.00
HUNTINGTON	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
PINK1	associated_with	gene	1.00
LRRK2	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
NEURODEGENERATIVE DISORDERS	associated_with	gene	1.00
ALS	associated_with	gene	1.00
FERROPTOSIS	associated_with	gene	1.00
NEURON	associated_with	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
MITOPHAGY	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
PINK1	associated_with	gene	1.00
OVERVIEW	associated_with	gene	1.00
AMYLOID	associated_with	gene	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
PTEN	activates	gene	1.00

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
Age-Accelerated miR-155 Upregulation Primes Nigral Microglia	0.610	neuroinflammation	How do regional, age, and sex-dependent
Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microg	0.500	neurodegeneration	How can AQP4 be effectively targeted the
Multi-Clock Ensemble Discordance as a Parkinson's Disease Pr	0.377	-	Epigenetic clocks as biomarkers for Alzh

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARKINSON in their description or question text

No additional research found