gene

PPP1R15A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1R15A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

40Outgoing

24Incoming

0Experiments

0Debates

Summary

PPP1R15A is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, implicated in. Associated with ALS, Als, Ms. Connected to 44 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPP1R15A
Aliases	GADD34
Chromosome	19q13
Protein Type	Gene
Function	encodes a stress-inducible scaffold that recruits catalytic PP1 phosphatase to phospho-eIF2alpha substrates.
Pathways	Blood-Brain Barrier, Er Stress
GeneCards	PPP1R15A
Human Protein Atlas	PPP1R15A
Neurons	PPP1R15A may influence synaptic maintenance versus stress-induced dendritic simplification via translational control.[@scheper2015][@halliday2015]
Associated Diseases	neurodegeneration
Interactions	AND, ATF4, CLDN5, CXCL1, CXCL2, CYTOKINES
KG Connections	64 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PPP1R15A Gene

gene · 890 words

→

PPP1R15A Protein (GADD34)

protein · 604 words

→

Pathway Diagram

graph TD
    PPP1R15A["PPP1R15A"]
    Ms{"Ms"}
    PPP1R15A -->|"therapeutic target"| Ms
    Als{"Als"}
    PPP1R15A -->|"therapeutic target"| Als
    PPP1R15A -->|"activates"| Als
    ALS{"ALS"}
    PPP1R15A -->|"activates"| ALS
    IL12B["IL12B"]
    PPP1R15A -->|"therapeutic target"| IL12B
    XBP1["XBP1"]
    PPP1R15A -->|"activates"| XBP1
    CXCL1["CXCL1"]
    PPP1R15A -->|"therapeutic target"| CXCL1
    DDIT3["DDIT3"]
    PPP1R15A -->|"activates"| DDIT3
    CLDN5["CLDN5"]
    PPP1R15A -->|"therapeutic target"| CLDN5
    HSPA5["HSPA5"]
    PPP1R15A -->|"activates"| HSPA5
    OCLN["OCLN"]
    PPP1R15A -->|"therapeutic target"| OCLN
    IL23A["IL23A"]
    PPP1R15A -->|"therapeutic target"| IL23A
    CXCL2["CXCL2"]
    CXCL2 -->|"therapeutic target"| PPP1R15A
    IL6["IL6"]
    IL6 -->|"therapeutic target"| PPP1R15A
    ATF4["ATF4"]
    ATF4 -->|"activates"| PPP1R15A
    IL12B -->|"therapeutic target"| PPP1R15A
    DDIT3 -->|"activates"| PPP1R15A
    CLDN5 -->|"therapeutic target"| PPP1R15A
    IL23A -->|"therapeutic target"| PPP1R15A
    OCLN -->|"therapeutic target"| PPP1R15A
    CXCL1 -->|"therapeutic target"| PPP1R15A
    CLDN5 -->|"activates"| PPP1R15A
    XBP1 -->|"activates"| PPP1R15A
    HSPA5 -->|"activates"| PPP1R15A
    style PPP1R15A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
Als	activates	disease	0.65
ALS	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
IL23A	activates	gene	0.60
CLDN5	activates	gene	0.60
ATF4	activates	gene	0.60
CXCL2	activates	gene	0.60
PERK	activates	gene	0.60
Er Stress	activates	pathway	0.60
Erk	activates	protein	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
App	therapeutic_target	protein	0.60
Endothelial	therapeutic_target	cell_type	0.60
Chemokine	therapeutic_target	protein	0.60
Cytokine	therapeutic_target	protein	0.60
CXCL2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
IL12B	therapeutic_target	gene	0.60
XBP1	activates	gene	0.60
CXCL1	therapeutic_target	gene	0.60
DDIT3	activates	gene	0.60
CLDN5	therapeutic_target	gene	0.60
HSPA5	activates	gene	0.60
OCLN	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60
IL12B	activates	gene	0.60
OCLN	activates	gene	0.60
IRE1	activates	gene	0.60
IL6	activates	gene	0.60
CXCL1	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
Blood-Brain Barrier	activates	pathway	0.60
CYTOKINES	activates	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Proteins	activates	protein	0.50
EIF2Α	activates	protein	0.50

Incoming (24)

Source	Relation	Type	Str
RNA	therapeutic_target	gene	0.60
CLDN5	activates	gene	0.60
IL12B	activates	gene	0.60
OCLN	activates	gene	0.60
IL6	activates	gene	0.60
IRE1	activates	gene	0.60
CXCL1	activates	gene	0.60
AND	activates	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
CXCL2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
ATF4	activates	gene	0.60
IL12B	therapeutic_target	gene	0.60
DDIT3	activates	gene	0.60
CLDN5	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60
OCLN	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
XBP1	activates	gene	0.60
HSPA5	activates	gene	0.60
CXCL2	activates	gene	0.60
IL23A	activates	gene	0.60
PERK	activates	gene	0.60
CYTOKINES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP1R15A in their description or question text

No additional research found