concept

RAPAMYCIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAPAMYCIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1395Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	RAPAMYCIN
Key Genes/Proteins	ACTB, ACTIN, AIF1, AKT, ALPHA-SYNUCLEIN, ALS4
Related Diseases	aging, AGING, ALS, ALZHEIMER, Alzheimer Disease

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

clinical · 4511 words

→

Pathway Diagram

graph TD
    RAPAMYCIN["RAPAMYCIN"]
    RAPAMYCIN -->|"inhibits"| MTORC1["MTORC1"]
    RAPAMYCIN -->|"inhibits"| MTOR["MTOR"]
    RAPAMYCIN -->|"activates"| SQSTM1["SQSTM1"]
    RAPAMYCIN -->|"activates"| RAS["RAS"]
    RAPAMYCIN -->|"activates"| STEM_CELLS["STEM CELLS"]
    RAPAMYCIN -->|"activates"| TFEB["TFEB"]
    RAPAMYCIN -->|"activates"| ULK1["ULK1"]
    PEROXISOME["PEROXISOME"] -->|"activates"| RAPAMYCIN
    LYSOSOME["LYSOSOME"] -->|"activates"| RAPAMYCIN
    LAMP1["LAMP1"] -->|"activates"| RAPAMYCIN
    PI3K["PI3K"] -->|"activates"| RAPAMYCIN
    AKT["AKT"] -->|"activates"| RAPAMYCIN
    BECN1["BECN1"] -->|"activates"| RAPAMYCIN
    AMPK["AMPK"] -->|"activates"| RAPAMYCIN
    LC3["LC3"] -->|"activates"| RAPAMYCIN

Outgoing (662)

Target	Relation	Type	Str
MTORC1	inhibits	protein	0.95
MTOR	inhibits	gene	0.95
MTORC1	targets	protein	0.95
ULK1	activates	gene	0.95
STEM CELLS	activates	cell_type	0.95
TFEB	activates	gene	0.95
SQSTM1	activates	gene	0.95
RAS	activates	gene	0.95
MTOR	inhibits	gene	0.92
GABARAP	targets	gene	0.90
LC3	targets	gene	0.90
aging	prevents	process	0.90
GABA	targets	gene	0.90
TFEB	targets	gene	0.90
Neuronal Death	suppresses	phenotype	0.90
Neurotoxic Astrocyte Effects	associated_with	phenotype	0.90
SQSTM1	downregulates	protein	0.90
autophagy	upregulates	process	0.90
seizures	treats	phenotype	0.90
Autophagy	activates	process	0.90
autophagy	activates	pathway	0.90
mTOR	inhibits	protein	0.90
ULK1	targets	gene	0.90
SQSTM1	targets	gene	0.90
MAP1LC3	targets	gene	0.90
LAMP1	targets	gene	0.90
GAPDH	targets	gene	0.90
RNA	targets	gene	0.90
ATG	targets	gene	0.90
BECN1	targets	gene	0.90
AMPK	targets	gene	0.90
AKT	targets	gene	0.90
RAS	targets	gene	0.90
PI3K	targets	gene	0.90
MTORC1	targets	gene	0.90
autophagy	activates	process	0.90
MAP1LC3B	targets	gene	0.90
MTOR	targets	gene	0.90
MTOR	targets	protein	0.89
MTORC1	inhibits	protein	0.87
Apoptosis	inhibits	process	0.86
autophagy pathway	modulates	pathway	0.85
Neurodegeneration	treats	disease	0.85
STING signaling	inhibits	process	0.85
Osteoarthritis	protects_against	disease	0.85
AUTOPHAGY	activates	process	0.85
Pericyte Senescence	treats	phenotype	0.82
MTOR	inhibits	gene	0.80
Depression	treats	disease	0.80
PIK3C3	targets	gene	0.80

Incoming (733)

Source	Relation	Type	Str
MTOR	regulates	gene	0.95
P62	activates	gene	0.95
PI3K	activates	gene	0.95
AUTOPHAGY	regulates	process	0.95
BECN1	activates	gene	0.95
LAMP1	activates	gene	0.95
LC3	activates	gene	0.95
AKT	activates	gene	0.95
MTOR	targets	gene	0.95
AMPK	activates	gene	0.95
MTOR	targets	gene	0.90
MTOR	targets	gene	0.80
GAPDH	activates	gene	0.80
APOPTOSIS	activates	process	0.80
BECN1	associated_with	gene	0.65
ASTROCYTES	targets	cell_type	0.65
BCL2	associated_with	gene	0.65
MICRORNA REGULATION	activates	process	0.65
CTSD	activates	gene	0.65
LAMP2	activates	gene	0.65
ALS	activates	disease	0.65
CREB	activates	gene	0.65
CANCER	activates	disease	0.65
TH	activates	gene	0.65
MTOR	interacts_with	gene	0.65
MICROGLIA	phosphorylates	cell_type	0.65
BCL2	activates	gene	0.65
MYC	activates	gene	0.65
HTT	inhibits	gene	0.65
P53	activates	gene	0.65
IGF1	regulates	gene	0.65
ALS	expressed_in	disease	0.65
TH	inhibits	gene	0.65
PARKIN	activates	gene	0.65
ENDOTHELIAL	interacts_with	cell_type	0.65
LC3	targets	gene	0.65
ISCHEMIA	targets	disease	0.65
IL1B	regulates	gene	0.65
BCL2	targets	gene	0.65
PI3K	phosphorylates	gene	0.65
CREB	interacts_with	gene	0.65
NEURON	interacts_with	cell_type	0.65
GSK3B	interacts_with	gene	0.65
P62	interacts_with	gene	0.65
DOPAMINERGIC	regulates	cell_type	0.65
NLRP3	expressed_in	gene	0.65
BAX	targets	gene	0.65
LAMP1	regulates	gene	0.65
OPTN	phosphorylates	gene	0.65
HUNTINGTON	interacts_with	disease	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.680

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Lysosomal membrane permeabilization releasing cathepsins triggers NLRP3 inflamma

closed · Rounds: 4 · Score: 0.76 · 2026-04-22

Related Research

Hypotheses and analyses mentioning RAPAMYCIN in their description or question text

No additional research found