Clinical Trials

RAPA-501 Therapy for ALS

NCT04220190 Phase II Recruiting

Rapa Therapeutics LLC 41 enrolled 2025-01-02 → 2026-07-01

RAPA-501-ALS is a phase 2/3 expansion cohort study of RAPA-501 autologous hybrid TREG/Th2 cells in patients living with amyotrophic lateral sclerosis (pwALS).

109

hypotheses

MAD Phase I Study to Investigate Contraloid Acetate

NCT03955380 Phase I Completed

Prof. Dr. Dieter Willbold 24 enrolled 2018-12-12 → 2019-04-03

This is a single-center multiple-ascending-dose clinical trial assessing the safety and tolerability of oral dosing of Contraloid acetate in healthy volunteers. The study drug Contraloid (alias RD2, a

109

hypotheses

Cerebrovascular Reactivity and Oxygen Metabolism as Markers of Neurodegeneration After Traumatic Brain Injury

NCT04820881 N/A Unknown

Washington D.C. Veterans Affairs Medical Center 60 enrolled 2021-10-01 → 2024-09

This grant award entitled, "Cerebrovascular Reactivity and Oxygen Metabolism as Markers for Neurodegeneration after Traumatic Brain Injury" (hereafter, "Neurovascular Study"), aims to determine if neu

109

hypotheses

Stereotactic Intracerebral Injection of Allogenic IPSC-DAPs in Patients With Parkinson's Disease

NCT07212088 Phase I Not Yet Recruiting

iCamuno Biotherapeutics Ltd. 12 enrolled 2026-02-28 → 2027-12-15

Parkinson's disease is a progressive neurodegenerative disorder characterized by high morbidity due to the limited regenerative capacity of dopaminergic neurons in the brain. Current drug treatments p

109

hypotheses

MRI Biomarkers in ALS

NCT02405182 N/A Completed

University of Alberta 145 enrolled 2014-09 → 2019-03

Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression. Increasing age is an important risk f

109

hypotheses

Activity of Cerebral Networks, Amyloid and Microglia in Aging and Alzheimer's Disease

NCT06224920 Unknown Completed

63

hypotheses

The Signature of Alzheimer's Disease in Subjective Cognitive Decline

NCT07402161 Unknown Recruiting

44

hypotheses

Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis

NCT06339190 Unknown Recruiting

43

hypotheses

Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease

NCT06206824 Phase I Recruiting

Perha Pharmaceuticals 164 enrolled 2024-01-18 → 2026-06

Leucettinib-21 First-in-Human Phase 1 Study in 6 Parts: Single (Part 1 and 5) and Multiple (Part 3 and 6) Ascending Doses, and Food-Effect (Part 2) in Healthy Subjects, and Single Dose (Part 4) in Peo

43

hypotheses

Cognitive-motor Training in Community-dwelling Older People With Mild Cognitive Impairment

NCT07241598 N/A Not Yet Recruiting

Mahidol University 70 enrolled 2025-12-01 → 2027-12-01

As the global population ages, the prevalence of mild cognitive impairment (MCI) among older adults, which ranges from 5% to 40%, is expected to rise. MCI significantly increases the risk of developin

40

hypotheses

The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Aging.

NCT05663918 N/A Unknown

McMaster University 36 enrolled 2023-02-13 → 2025-01-01

The research is focused on ameliorating cognitive decline in aging and in individuals diagnosed with Mild Cognitive Impairment (MCI). In the proposed research, we ask whether synaptic plasticity is mo

40

hypotheses

Clinical, Molecular and Electrophysiological Profiling of Parkinson's Disease: the Role of Non-pharmacological Therapies

NCT05807581 N/A Unknown

Fondazione Policlinico Universitario Agostino Geme 400 enrolled 2023-06-09 → 2025-05-30

In Parkinson's disease (PD), direct evidence linking inflammation to the harmful activities of alpha-synuclein (a-syn) aggregates, the disease onset, and its progression is still lacking. This transla

29

hypotheses

A Noval Tau Tracer in Young Onset Dementia

NCT04248270 Phase I Unknown

Chang Gung Memorial Hospital 100 enrolled 2020-02-20 → 2023-08-17

Dementia is a clinical syndrome which characterized by progressive cognitive impairment, behavior disturbance and dysfunction of daily activity. In aging population, Alzheimer's dementia (AD) is the m

28

hypotheses

Physical Activity in Patients With Parkinson's Disease: a "Disease Modifying" Intervention?

NCT05815524 N/A Terminated

Fondazione Policlinico Universitario Agostino Geme 30 enrolled 2022-05-02 → 2024-12-31

Parkinson's disease (PD) is a neurodegenerative disease characterized by bradykinesia, rigors, and tremor at rest. Distinctive neuropathological signs include progressive loss of dopaminergic neurons

27

hypotheses

An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Th

NCT06875739 Unknown Enrolling

Fondazione Don Carlo Gnocchi Onlus 310 enrolled 2025-02-14 → 2026-10-01

The aim of the study is to validate a salivary test that allows for rapid and accurate objective diagnosis in the context of neurodegenerative diseases, a complex of diseases that includes Alzheimer's

27

hypotheses

Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients

NCT04388254 Phase II Completed

Cassava Sciences, Inc. 220 enrolled 2020-03-24 → 2023-11-09

A two-year safety study of simufilam (PTI-125) 100 mg oral tablets twice daily for participants of the previous simufilam studies as wells as additional new mild-to-moderate Alzheimer's disease subjec

22

hypotheses

Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI

NCT04887675 N/A Unknown

University of Novi Sad 120 enrolled 2021-05-01 → 2022-06-01

Since the HIV changed its course to the chronic disease, high incidence of metabolic syndrome both in HIV positive and negative subjects has become an issue. Given the successful peripheral suppressio

20

hypotheses

Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

NCT00029965 Unknown Recruiting

National Human Genome Research Institute (NHGRI) 200 enrolled Started 2002-02-06

Study description: This is a natural history study that will evaluate any patient with enzyme or DNA confirmed GM1 or GM2 gangliosidosis, sialidosis or galactosialidosis. Patients may be evaluated ev

20

hypotheses

Retinal and Cognitive Dysfunction in Type 2 Diabetes

NCT04281186 Unknown Completed

Hospital Universitari Vall d'Hebron Research Insti 510 enrolled 2020-11-16 → 2024-12-12

The retina shares similar embryologic origin, anatomical features and physiological properties with the brain and hence offers a unique and accessible "window" to study the correlates and consequences

20

hypotheses

Randomized I/II Phase Study of ALZT-OP1 Combination Therapy in Alzheimer's Disease and Normal Healthy Volunteers

NCT04570644 Phase I Completed

17

hypotheses

DORA and LP in Alzheimer's Disease Biomarkers

NCT06274528 Phase II Recruiting

Washington University School of Medicine 201 enrolled 2024-03-11 → 2029-03-11

The purpose of this study is to see if the sleep aid, lemborexant, can decrease the amount of amyloid-beta and tau in the blood. Amyloid-beta and tau are proteins involved in the disease process leadi

15

hypotheses

Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder

NCT04048603 N/A Unknown

Chinese University of Hong Kong 182 enrolled 2019-05-15 → 2022-03-31

This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development

13

hypotheses

Efficacy of Dorzolamide as an Adjuvant After Focal Photocoagulation in Clinically Significant Macular Edema

NCT02227745 N/A Unknown

Hospital Juarez de Mexico 60 enrolled 2014-01 → 2015-03

Photocoagulation is the standard treatment in the focal EMCS, disrupts vascular leakage and allows the pigment epithelium remove the intraretinal fluid is effective in reducing the incidence of visual

13

hypotheses

Evaluation of the Frequency and Severity of Sleep Abnormalities in Patients With Parkinson's Disease

NCT04387812 N/A Unknown

Tel-Aviv Sourasky Medical Center 240 enrolled 2020-06-01 → 2023-12-31

Sleep disturbances are one of the most common non-motor symptoms in PD, with an estimated prevalence as high as 40-90%. Sleep disturbances (particularly sleep duration, sleep fragmentation, Rapid Eye

13

hypotheses

Ambroxol in Disease Modification in Parkinson Disease

NCT02941822 Phase II Completed

University College, London 23 enrolled 2016-12 → 2018-04

This study will evaluate the safety, tolerability and pharmacodynamics of ambroxol in participants with Parkinson Disease. Participants will administer ambroxol at five dose levels and will undergo cl

13

hypotheses

Development of a Novel 18F-DTBZ PET Imaging as a Biomarker to Monitor Neurodegeneration of PARK6 and PARK8 Parkinsonism

NCT01759888 Phase II Completed

Chang Gung Memorial Hospital 49 enrolled 2011-08 → 2014-12

The primary objective of this protocol is to access the utility of 18F-DTBZ PET imaging as an in vivo biomarker to monitor neurodegeneration of both PD mouse models and PD patients. Secondary, the inv

13

hypotheses

The Analysis of Gene Variants Related to POCD in Elderly Patients

NCT05419596 Unknown Unknown

12

hypotheses

Ferrochelating Treatment in Patients Affected by Neurodegeneration With Brain Iron Accumulation (NBIA)

NCT00907283 Phase II Unknown

Ente Ospedaliero Ospedali Galliera 20 enrolled 2008-11 → 2024-12

This trial is a multicenter, unblinded, single-arm pilot study, lasting one year (plus one year extension Amendment n.3 25 August 2009, plus two years follow-up Amendment n.7) , to evaluate the effica

11

hypotheses

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study

NCT04685590 Phase II Active

11

hypotheses

Association of VAgus Nerve Stimulation and Treadmill Training for GAit Rehabilitation in DE Novo Parkinson's Disease

NCT07337226 N/A Not Yet Recruiting

Fondazione Policlinico Universitario Campus Bio-Me 60 enrolled 2026-01 → 2027-10

The goal of this clinical trial is to learn if transcutaneous auricular vagus nerve stimulation (taVNS) can improve gait and brain function in people with diagnosis of idiopathic Parkinson's disease (

10

hypotheses

The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.

NCT04562831 N/A Active

Haukeland University Hospital 380 enrolled 2020-10-07 → 2026-10-31

Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The average survival from the time of diagnosis is 3 years. Apart from Riluzole, there is no effecti

10

hypotheses

Effect of the Vojta Therapy in Patients Multiple Sclerosis

NCT05558683 N/A Unknown

Aymara Abreu Corrales 25 enrolled 2022-12-01 → 2023-06-01

Multiple sclerosis is the most common disabling neurological disease in young adults. Inflammation, demyelination, neurodegeneration, gliosis and repair processes are involved in its process, which ar

10

hypotheses

The Effect of RNS60 on ALS Biomarkers

NCT03456882 Phase II Completed

Mario Negri Institute for Pharmacological Research 147 enrolled 2017-05-30 → 2020-11-23

Amyotrophic Lateral Sclerosis (ALS) is a rare lethal neurodegenerative disease involving inflammation. Riluzole, the only drug for ALS, improves median survival by 3 months. This prompts new treatment

10

hypotheses

N-Acetylcysteine for Neurodegeneration in PD

NCT03514875 Phase II Completed

10

hypotheses

A Study of an Investigational Drug to See How it Affects the People With Parkinson's Disease Complicated by Motor Fluctu

NCT03391882 Phase III Completed

Sumitomo Pharma America, Inc. 113 enrolled 2018-12-19 → 2021-08-11

A study of an investigational drug to see how it affects the people with Parkinson's Disease complicated by motor fluctuations ("OFF" Episodes) compared to an approved drug used to treat people with P

10

hypotheses

Protective Anesthesiological Management Procedure Imposes Control on Respiratory Comlications

NCT06282003 N/A Unknown

Masa Kontic 53 enrolled 2023-10-10 → 2024-06-30

Anesthetic effects, surgery, and invasive mechanical intubation can impair respiratory function during general anesthesia. The risk factors for postoperative pulmonary complications (PPCs) include the

10

hypotheses

Long-Term Safety of PRC-063 in Adolescents and Adults With ADHD

NCT02168127 Phase III Completed

Rhodes Pharmaceuticals, L.P. 360 enrolled 2014-05 → 2015-05

The purpose of this six month, open-label study is to evaluate the long-term safety and efficacy of PRC-063 in adults and adolescents with ADHD.

10

hypotheses

5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor

NCT02632370 N/A Completed

Constantinos Hadjipanayis 69 enrolled 2016-05 → 2018-12-31

In support of the US marketing application for 5-ALA, this single arm trial is being conducted to establish the efficacy and safety of Gliolan® (5-ALA) in patients with newly diagnosed or recurrent ma

10

hypotheses

Magnetic Resonance Imaging of Brain Development in Autism

NCT00449566 N/A Unknown

UMC Utrecht 300 enrolled Started 2006-01

The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We wil

10

hypotheses

PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer's Disease With Machine Learning

NCT05569083 N/A Unknown

Azienda Ospedaliero-Universitaria Careggi 350 enrolled 2020-10-01 → 2023-09-30

Alzheimer's disease (AD) has a presymptomatic course which can last from several years to decades. Identification of subjects at an early stage is crucial for therapeutic intervention and possible pre

10

hypotheses

Deferiprone for Iron Reduction in Alzheimer's Disease

NCT03234686 Phase II Completed

9

hypotheses

Effect of Selenium on Mild Cognitive Impairment

NCT03533257 Phase II Completed

9

hypotheses

Pioglitazone in Alzheimer Disease (TOMORROW)

NCT00000145 Phase III Completed

9

hypotheses

Vitamin E and Selenium in Preventing AD

NCT05081219 Phase II Recruiting

9

hypotheses

An Extension Study to Evaluate the Long-Term Safety and Tolerability of JNJ-54861911 in Participants in the Early Alzhei

NCT02406027 Phase II Terminated

9

hypotheses

The Effects of a Novel NMDA NR2B-Subtype Selective Antagonist, EVT 101, on Brain Function

NCT00526968 Phase I Completed

Evotec Neurosciences GmbH 19 enrolled 2007-09 → 2007-12

The purpose of this study is to investigate the neurophysiological changes following single doses of EVT 101 using fMRI during rest and during cognitive tasks in young healthy male subjects.

9

hypotheses

The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability

NCT05155397 N/A Active

Technical University of Dortmund 627 enrolled 2016-04 → 2035-12

The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabo

9

hypotheses

DL-3-n-butylphthalide Treatment in Patients With Mild to Moderate Alzheimer's Disease Already Receiving Donepezil

NCT02711683 N/A Completed

First Affiliated Hospital Xi'an Jiaotong Universit 92 enrolled 2016-03 → 2019-12

Alzheimer's disease (AD) is the commonest cause of dementia. There is no effective treatment to cure the disease. Cholinesterase inhibitors, such as donepezil, are widely recommended to patients with

9

hypotheses

ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults

NCT07392723 Phase II Recruiting

Michal Schnaider Beeri, Ph.D. 20 enrolled 2025-01-12 → 2027-04

This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain va

9

hypotheses

Neuroinflammation in FTLD

NCT06870838 N/A Active

The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are: 1. To elucidate the role and timing

9

hypotheses

Continuation of The Kronos Early Estrogen Prevention Study (KEEPS)

NCT03718494 Unknown Completed

8

hypotheses

Clinical Safety and Efficacy Evaluation of NanoLithium® NP03 in Patients With Mild-to-severe Alzheimer's Disease

NCT05423522 Phase II Completed

8

hypotheses

Efavirenz (CYP46A1 Activator) in Early AD

NCT03706885 Phase I Completed

8

hypotheses

A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease

NCT01928420 Phase II Completed

Humanetics Corporation 30 enrolled 2007-04 → 2014-06

The purpose of this study is to evaluate the safety and efficacy of NIC5-15 in the treatment of Alzheimer's Disease.

8

hypotheses

Predictive Role of sTREM in Endovascular Thrombectomy Outcomes

NCT06545591 Unknown Recruiting

The Affiliated Hospital of Xuzhou Medical Universi 300 enrolled 2024-07-01 → 2027-12-31

Soluble triggering receptor expressed on myeloid cells (sTREM), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. This study is to i

7

hypotheses

Rapamycin in AD (REACH)

NCT04629495 Phase II Recruiting

7

hypotheses

A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's Disease

NCT05541627 Phase I Active

Brainvectis, a subsidiary of Asklepios BioPharmace 5 enrolled 2022-10-12 → 2024-04-04

A Phase I/II Dose-Finding Study to Evaluate Striatal Administration of AB-1001 (previously BV-101) in Adults with Early Manifest Huntington's Disease

7

hypotheses

Clinical trial NCT03808389

NCT03808389 Unknown Unknown

7

hypotheses

Clinical trial NCT03671785

NCT03671785 Unknown Unknown

7

hypotheses

Clinical trial NCT02269150

NCT02269150 Unknown Unknown

7

hypotheses

Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease

NCT04838301 Phase II Recruiting

University of Arizona 100 enrolled 2023-08-15 → 2026-11-18

A phase 2, double-blind, randomized, placebo-controlled clinical trial to evaluate the safety and efficacy of Allopregnanolone as a regenerative therapeutic for Alzheimer's disease.

6

hypotheses

Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function

NCT02460783 N/A Completed

National Institute on Aging (NIA) 129 enrolled 2015-06-22 → 2022-01-14

6

hypotheses

Understanding Cerebral Blood Flow Dynamics for Alzheimer's Disease Prevention Through Exercise

NCT06584656 N/A Completed

6

hypotheses

Impact of Bosutinib on Safety, Tolerability, Biomarkers and Clinical Outcomes in Dementia With Lewy Bodies

NCT03888222 Phase II Completed

Georgetown University 26 enrolled 2019-04-23 → 2021-08-27

This study evaluates the effect of Bosutinib (Bosulif,Pfizer®) in the treatment of patients with Dementia with Lewy Bodies. Half participants will receive 100 mg of Bosutinib , while the other half wi

6

hypotheses

Hyperhomocysteinemia in Alzheimer's Disease

NCT05793372 Unknown Unknown

Central Hospital, Nancy, France 43 enrolled 2023-06 → 2023-06

6

hypotheses

Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging

NCT07474779 N/A Not Yet Recruiting

5

hypotheses

Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease

NCT05422885 Phase I Completed

5

hypotheses

Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease

NCT01689246 Phase III Completed

TauRx Therapeutics Ltd 891 enrolled 2013-01 → 2015-11

The purpose of this study is to determine the safety and efficacy of TRx0237 in the treatment of subjects with mild to moderate Alzheimer's Disease.

5

hypotheses

A Study of RO5313534 as Add-on to Donepezil Treatment in Patients With Mild to Moderate Alzheimer's Disease

NCT00884507 Phase II Completed

Hoffmann-La Roche 389 enrolled 2009-05 → 2010-11

This 4 arm study will assess the efficacy and safety of RO5313534 (MEM3454) versus placebo added to donepezil, in patients with mild to moderate Alzheimer's disease. Following a screening period, pati

5

hypotheses

Effects of a Cognitive-Engaging Strength Training Program on Health, Physical Condition, and Quality of Life in People W

NCT07022431 N/A Not Yet Recruiting

University of Seville 34 enrolled 2025-10 → 2025-10

The primary objective of this project is to examine the impact of a strength training program with high cognitive demands on cognitive function, motor skills, physical fitness, and quality of life in

5

hypotheses

A Study Of Oral PF-01913539 In Patients With Mild To Moderate Alzheimer's Disease

NCT01066481 Phase II Withdrawn

Pfizer 2010-04 → 2012-03

The purpose of this study is to demonstrate the safety and efficacy of PF-01913539 in the treatment of patients with mild-to-moderate Alzheimer's Disease. It is a 6-month study enrolling 651 patients

5

hypotheses

NMN Supplementation for Cognitive Function in Older Adults

NCT05617508 Phase II Recruiting

5

hypotheses

Brain Cholesterol Biomarkers in Preclinical AD

NCT05538455 Observational Recruiting

5

hypotheses

Sirtuin-NAD Activator in Alzheimer's Disease

NCT05040321 Phase I Active

Brigham and Women's Hospital 22 enrolled 2021-12-01 → 2025-12-15

The primary objectives are to: 1. To determine whether MIB-626, after its daily oral administration, penetrates the blood-brain barrier in humans by measuring the cerebrospinal fluid (CSF) concentrat

5

hypotheses

Safety Study of AADvac1, a Tau Peptide-KLH-Conjugate Active Vaccine to Treat Alzheimer's Disease

NCT01850238 Phase I Completed

5

hypotheses

Genetic Studies of Early-onset Dementia

NCT04906863 Unknown Recruiting

5

hypotheses

Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease

NCT04413344 Phase I Completed

5

hypotheses

Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Interven

NCT03978052 N/A Completed

5

hypotheses

Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial

NCT05189106 Phase I Completed

Massachusetts General Hospital 17 enrolled 2022-12-05 → 2025-04-24

5

hypotheses

Digital Evaluations and Technologies Enabling Clinical Translation for AD

NCT05385913 N/A Unknown

Oregon Health and Science University 200 enrolled 2022-04-01 → 2024-06-30

The DETECT-AD study (stands for "Digital Evaluations and Technologies Enabling Clinical Translation for Alzheimer's Disease") is a new study designed to improve clinical trials for early Alzheimer's d

5

hypotheses

Circadian Rhythm and Other Factors in Memory Clinic Patients

NCT05977712 N/A Recruiting

Assistance Publique - Hôpitaux de Paris 1,200 enrolled 2024-03-06 → 2027-03

The CIRCAME study is a bicentric study of patients from 2 memory clinics in Paris. The main objective is to identify circadian rhythm components and other individual risk factors (sociodemographic, be

5

hypotheses

Retinal Neurodegeneration in Type 2 Diabetes as Biomarker for Alzheimer´s Disease

NCT02360527 N/A Completed

Hospital Universitari Vall d'Hebron Research Insti 126 enrolled 2014-09 → 2015-11

A clear association between type 2 diabetes (T2D) and Alzheimer's disease (AD) has been reported. This association is independent of vascular impairment, and therefore, it could be attributed to neuro

5

hypotheses

Cognitive Functioning and Quality of Life in CNS Lymphoma

NCT00581737 N/A Completed

Memorial Sloan Kettering Cancer Center 50 enrolled 2000-07 → 2009-08

The purpose of this study is to evaluate several aspects of thinking abilities including attention and memory, and quality of life in patients who were diagnosed with and treated for Primary CNS Lymph

5

hypotheses

Effect of the Plantago Ovata Husk on the Lipid Profile of Patients With Hypercholesterolemia

NCT00502047 Phase II Completed

Rottapharm Spain 255 enrolled Started 2005-09

The hypothesis of this study is that soluble fibre may contribute to a reduction of the low density lipoprotein cholesterol (LDL-c), and the combined effect with a statin may achieve an optimisation o

5

hypotheses

EAGLE: Evaluating Genotypes Using Intravitreal Aflibercept Injection

NCT02689518 Phase IV Completed

University of California, San Diego 50 enrolled 2014-04 → 2019-11-12

Clinical and genetic evaluation of individuals treated with intravitreal aflibercept injection (Eylea) for neovascular age-related macular degeneration (wet AMD)

5

hypotheses

Peripheral Blood VA/TREM2 Levels and Their Correlation Analysis With the Development and Autistic Symptoms in Children W

NCT06188429 N/A Unknown

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social impairment, repetitive behaviors, and narrow interests. With advancements in diagnostic techniques, the prevalen

5

hypotheses

LIFE-DSR-Biomarker Sub-study of Biomarkers in Down Syndrome Related Alzheimer's Disease (DS-AD)

NCT06860373 Phase III Terminated

This is an optional sub-study that will enroll participants from the LIFE-DSR parent protocol. Participants will undergo assessments at two timepoints, including: additional blood samples for PBMC and

5

hypotheses

Resveratrol for Mild-to-Moderate Alzheimer's Disease

NCT04430517 Phase III Completed

4

hypotheses

SRT2104 (Selective SIRT1 Activator) in Healthy Elderly

NCT03482167 Phase I Completed

4

hypotheses

Niacin (NAD+ Precursor) in Parkinson's Disease

NCT02942888 Phase II Completed

4

hypotheses

Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis

NCT04688788 Phase III Active

Rigshospitalet, Denmark 600 enrolled 2021-04-28 → 2026-05-05

The DanNORMS study is a phase 3, non-inferiority clinical trial examining whether treatment of active multiple sclerosis with rituximab is non-inferior to ocrelizumab regarding efficacy and safety.

4

hypotheses

Effect of CT1812 Treatment on Brain Synaptic Density

NCT03493282 Phase I Completed

Cognition Therapeutics 43 enrolled 2018-03-28 → 2020-10-16

Study to Evaluate the Safety and Tolerability of Oral CT1812 in Subjects with Mild to Moderate Alzheimer's Disease.

4

hypotheses

Precision Medicine in the Treatment of Epilepsy

NCT05450822 N/A Recruiting

Gitte Moos Knudsen 550 enrolled 2022-02-18 → 2026-12-31

Primary objectives: The purpose of this study is to identify single and composite biomarkers (from neuroimaging, electrophysiological, and non-imaging biological measures), clinical measures (from co

4

hypotheses

Amyotrophic Lateral Sclerosis (ALS) Families Project

NCT03865420 Unknown Recruiting

Columbia University 300 enrolled 2018-09-11 → 2027-01

This program provides family members of individuals with familial ALS the opportunity to contribute to research focused on learning more about why motor neuron degeneration begins and how or why it pr

4

hypotheses

Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Dise

NCT05469009 Early Phase I Active

4

hypotheses

Everolimus in Aging (PEARL)

NCT04200911 Phase II Active

4

hypotheses

Study Of Rosiglitazone XR In Subjects With Mild-to-Moderate Alzheimers

NCT00550420 Phase III Terminated

4

hypotheses

A Nutritional Intervention for Body, Brain, and Longevity Effects (NIBBLE)

NCT06682767 N/A Not Yet Recruiting

4

hypotheses

Baricitinib for Neuroinflammation in AD

NCT04063124 Phase II Recruiting

4

hypotheses

Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.

NCT07361887 N/A Recruiting

This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults. EVs are small particles released by cells that carry proteins, lipid

4

hypotheses

Clinical trial NCT02303158

NCT02303158 Unknown Unknown

4

hypotheses

Clinical trial NCT04428684

NCT04428684 Unknown Unknown

4

hypotheses

Implementation and Evaluation of a Rare Disease Algorithm to Identify Persons at Risk of Gaucher Disease Using Data From

NCT05908656 N/A Completed

Sanofi 13 enrolled 2024-04-02 → 2024-08-26

This is a three-phase study comprising both retrospective and prospective components, as follows: Phase I: Deployment of Rare Disease Algorithm: A diagnostic screening algorithm was developed using

4

hypotheses

Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18

NCT02292654 Phase I Completed

Genzyme, a Sanofi Company 20 enrolled 2015-05-01 → 2019-12-09

Primary Objective: To evaluate the safety and tolerability of olipudase alfa administered intravenously in pediatric participants every 2 weeks for 64 weeks. Secondary Objective: To characterize th

4

hypotheses

Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase D

NCT02004691 Phase II Completed

Genzyme, a Sanofi Company 36 enrolled 2015-12-18 → 2021-03-15

Primary Objective: The primary objective of this phase 2/3 study was to evaluate the efficacy of olipudase alfa (recombinant human acid sphingomyelinase) administered intravenously once every 2 weeks

4

hypotheses

Data Analysis of Adult and Pediatric Participants With Acid Sphingomyelinase Deficiency (ASMD) on Early Access to Olipud

NCT05359276 Unknown Completed

Sanofi 40 enrolled 2022-06-10 → 2024-12-31

Primary Objective: To describe the lung, spleen and liver outcomes of olipudase alfa Secondary Objectives: * To describe the patient's characteristics * To describe conditions of olipudase alfa use

4

hypotheses

Compassionate Use Program for Olipudase Alfa Enzyme Replacement Therapy for Patients With Chronic Acid Sphingomyelinase

NCT04877132 Unknown APPROVED_FOR_MARKETING

The objective of this program is to provide access to enzyme replacement therapy (ERT) with olipudase alfa for certain patients with ASMD, a severe, life threatening disease, that could not participat

4

hypotheses

Dyslipidemia and Diabetic Retinopathy

NCT03403283 Unknown Completed

University of Alabama at Birmingham 45 enrolled 2014-01 → 2023-04-30

The purpose of this study is to determine if the reparative cells of blood vessels called endothelial progenitor cells(EPC) are defective in people with diabetes.

4

hypotheses

A Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention

NCT05269667 Phase IV Terminated

Hoffmann-La Roche 4 enrolled 2022-08-02 → 2023-10-26

Objective of the trial is to describe the efficacy and safety of satralizumab in patients with aquaporin-4 (AQP4) antibody seropositive NMOSD, either treatment naive or inadequate responders to previo

4

hypotheses

Low-Dose Lithium for AD Prevention

NCT04098666 Phase II Recruiting

4

hypotheses

Early Diagnosis of SCD Based on Radiogenomics

NCT04696315 Unknown Unknown

3

hypotheses

Ambroxol in New and Early DLB, A Phase IIa Multicentre Randomized Controlled Double Blind Clinical Trial

NCT04588285 Phase II Unknown

3

hypotheses

Prevent Cognitive Decline in GBA-associated Parkinson's Disease

NCT07055087 Phase II Not Yet Recruiting

3

hypotheses

Ioflupane I123 (DaTSCAN) and Positron Emission Tomography-computed Tomography Fludeoxyglucose (PET-CT FDG) to Assess Bra

NCT01089283 Unknown Unknown

3

hypotheses

Drug Discovery for Parkinson's With Mutations in the GBA Gene

NCT05536388 Unknown Recruiting

3

hypotheses

Detecting Early Myocardial Infiltration w/Amyloid & Light Chain Deposition Disease in Multiple Myeloma Subjects

NCT01018927 N/A Terminated

University of Arkansas 44 enrolled 2009-06 → 2017-05-30

The purpose of this study is to see if MRI techniques can be used for early evaluation of cardiac amyloidosis which is sometimes seen in individuals with multiple myeloma. Cardiac amyloidosis is a med

3

hypotheses

Post-stroke Cognitive Impairment and Dementia

NCT01339195 N/A Completed

Centre Hospitalier Universitaire, Amiens 1,635 enrolled 2010-08 → 2016-12

Projections from epidemiological studies suggest that, among the Western adult population, one in three will present a cerebrovascular accident (stroke), severe cognitive disorders, or both. To better

3

hypotheses

A Study Investigating the Effectiveness of a LifeSeasons NeuroQ Supplement With Lifestyle Changes to Improve Cognitive F

NCT04149639 N/A Completed

LifeSeasons Inc. 40 enrolled 2019-11-08 → 2020-07-07

The objective of this study is to evaluate the efficacy of a NeuroQ supplement designed by Dr. Bredesen to complement his Lifestyle modification protocol. Eligible participants will be expected to con

3

hypotheses

Improving Caregiver Mediated Medication Management- The 3M Study

NCT03127930 N/A Completed

University of Pittsburgh 183 enrolled 2010-06-01 → 2013-07-30

This study sought to improve medication management by caregivers of community dwelling patients with dementia or simple memory loss. This was done by testing a tailored intervention delivered both in-

3

hypotheses

Improving Mood and Behavior in Assisted Living Residents Through Skills Training for Their Caregivers

NCT00255866 Phase II Completed

University of Washington 90 enrolled 2004-01 → 2006-12

This study will develop a treatment program to reduce mood and behavior problems in assisted living residents who have dementia.

3

hypotheses

Long-term Prospective Study of Korean CADASIL Patients

NCT07497867 Unknown Recruiting

3

hypotheses

The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals

NCT03326648 N/A Completed

Truls Raastad 34 enrolled 2016-09-01 → 2017-12-20

The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors a

3

hypotheses

Trial for Relapsed or Refractory AML Patients Combining Cytarabine and Mitoxantrone With Venetoclax (RELAX)

NCT04330820 Phase I Unknown

Technische Universität Dresden 55 enrolled 2020-04-06 → 2023-10-11

This is an open-label Phase I dose-escalation study of oral venetoclax in combination with increasing cytarabine doses plus mitoxantrone to define the safety profile and MTD of cytarabine in subjects

3

hypotheses

NR (Nicotinamide Riboside) in Mild Cognitive Impairment

NCT03731923 Phase II Completed

3

hypotheses

Resveratrol for Alzheimer's Disease (Phase II)

NCT01504854 Phase II Completed

3

hypotheses

Omics of Rituximab-resistance

NCT07416942 N/A Not Yet Recruiting

Mario Negri Institute for Pharmacological Research 120 enrolled 2026-04 → 2029-03

The CONFUCIUS project aims to establish a personalised medicine framework for MN patients by integrating pharmacogenomics with other -omics technologies in order to identify biomarkers that predict re

3

hypotheses

The Effectivity of Anti Tuberculosis Therapy in Idiopathic Uveitis with Positive IGRA

NCT05005637 Phase II Completed

Fakultas Kedokteran Universitas Indonesia 78 enrolled 2021-08-27 → 2024-10-20

The reported incidence of uveitis is 52 persons per year per 100,000 population, with a greater incidence estimated in developing countries, including Indonesia. Uveitis has challenges in diagnosis an

3

hypotheses

Mobilising Tumour and Immune Cells Via Exercise in Chronic Lymphocytic Leukaemia

NCT05093192 N/A Completed

University of Bath 26 enrolled 2021-10-01 → 2022-12-06

Chronic lymphocytic leukaemia (CLL) is the most common adult blood cancer in the United Kingdom. CLL means that many cancer cells appear in the blood, bone marrow and other tissues, for example, the s

3

hypotheses

Combined Apheresis for ABO-incompatible Transplantation - a Pilot Study

NCT02120482 N/A Terminated

Medical University of Vienna 4 enrolled 2014-10 → 2022-07-31

Recipient desensitization is a prerequisite for successful ABO-incompatible kidney transplantation (ABOi-KTX). Published desensitization protocols commonly include the use of plasmapheresis or selecti

3

hypotheses

AAV-BDNF Gene Therapy for AD

NCT04885114 Phase I Recruiting

3

hypotheses

Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound

NCT04118764 N/A Completed

3

hypotheses

Condensate Biology Biomarkers in ALS

NCT05269381 Observational Recruiting

3

hypotheses

Lipoic Acid (Lipoamide Analog) in AD

NCT04070378 Phase II Active

3

hypotheses

Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment

NCT06321588 Unknown Recruiting

Azienda Usl di Bologna 300 enrolled 2023-05-10 → 2026-06-30

3

hypotheses

Venglustat (GCS inhibitor) for GBA-Parkinson's

NCT02906020 Phase II Completed

3

hypotheses

TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.

NCT07399418 Unknown Recruiting

Istituti Clinici Scientifici Maugeri SpA 80 enrolled 2025-09-01 → 2027-07-31

The study is based on the hypothesis that the integration of biological, psychological, and social factors, according to the biopsychosocial paradigm, allows for more accurate identification of the di

3

hypotheses

In Vivo CRISPR for Transthyretin Amyloidosis (NTLA-2001)

NCT05603312 Phase III Active

3

hypotheses

Adapting Connect-Home Transitional Care for the Unique Needs of Persons With Alzheimer's Disease and Other Dementias and

NCT05887388 N/A Completed

University of North Carolina, Chapel Hill 38 enrolled 2021-09-10 → 2022-02-27

This primary purpose of this study will be to (1) examine the feasibility and acceptability of transitional care focusing on care needs of skilled nursing facility (SNF) patients with dementia and the

3

hypotheses

Effects of Electroacupuncture on Cognitive Symptoms in Major Depressive Disorder

NCT06239740 N/A Completed

Thammasat University 60 enrolled 2022-12-24 → 2023-01-24

The goal of this pilot Study and Randomized Controlled Trial is to investigate the impact of electroacupuncture on cognitive function, quality of life (QoL), and depression severity in patients with m

3

hypotheses

Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment

NCT00306124 Phase IV Unknown

University Hospital Muenster 120 enrolled Started 2006-01

This study aims to determine whether levodopa is effective in boosting learning and memory in healthy subjects and patients with dementia or Mild Cognitive Impairment. We also examine in healthy subj

3

hypotheses

Deep Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease

NCT00753662 Phase II Unknown

Tel-Aviv Sourasky Medical Center 45 enrolled 2008-11 → 2012-11

The primary objective of this trial is to assess the ability of Transcranial Magnetic Stimulation with H2 coil to prefrontal and parieto-temporal cortex to improve cognitive performance in patients wi

3

hypotheses

Autologous Mitochondrial Transfer for Ischemia

NCT04998357 Phase I Recruiting

3

hypotheses

Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistic

NCT07146412 N/A Recruiting

3

hypotheses

AC-1204 26-Week Long Term Efficacy Response Trial With Optional Open-label Ext

NCT01741194 Phase II Completed

3

hypotheses

CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke

NCT06078215 Phase IV Unknown

The study investigates whether Cerebrolysin stabilizes blood-brain barrier integrity in a manner that can be monitored using serum levels of the principal tight junction proteins, e.g., occludin (OCL)

3

hypotheses

The Cognitive-Behavioral Dysfunctions and the Potential of Neuroplasticity in Brain Tumors Patients During Radiotherapy

NCT05192447 N/A Unknown

Primary and secondary brain tumors are a constant challenge for the medicine. Tissue sensitivity to ionizing radiation differs and depends on numerous factors and the same dose of radiation may produc

3

hypotheses

The Swedish BioFINDER Study

NCT01208675 N/A Completed

Skane University Hospital 1,150 enrolled 2010-09 → 2024-12

The present study aims at combining biochemical methods with various types of imaging techniques to identify the pathophysiology of Alzheimer's disease (AD). The main interest is to find markers assoc

3

hypotheses

Detection of Disease-Related Changes in Pre-Symptomatic Alzheimer's Disease

NCT01841905 N/A Unknown

Rhode Island Hospital 60 enrolled 2013-07 → 2016-12

The investigators are conducting a study to try to improve our ability to identify older adults who are at high-risk for progression to Alzheimer's disease, several years before they have symptoms tha

3

hypotheses

Exploring to Remediate Behavioral Disturbances of Spatial Cognition

NCT05944601 N/A Active

Istituto Auxologico Italiano 83 enrolled 2023-03-01 → 2024-02-28

Spatial navigation (SN) has been reported to be one of the first cognitive domains to be affected in Alzheimer's disease (AD), which occurs as a result of progressive neuropathology involving specific

3

hypotheses

Comfortage - AD Prevention Strategies

NCT06896201 N/A Not Yet Recruiting

Fondazione Policlinico Universitario Agostino Geme 200 enrolled 2025-09 → 2027-03

Study is Interventional, cross-sectional, clinical trial without drug and without device

3

hypotheses

Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease

NCT00348309 N/A Completed

GlaxoSmithKline 1,496 enrolled 2006-07-06 → 2009-01-01

Rosiglitazone (RSG) has been tested in clinical studies and is approved by the FDA as a treatment for type II diabetes mellitus, a disease that occurs when the body is unable to effectively use glucos

3

hypotheses

Study Evaluating the Safety and Efficacy of Bapineuzumab in Alzheimer Disease Patients

NCT00676143 Phase III Terminated

Pfizer 1,100 enrolled 2008-01 → 2012-10

This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab or placebo. Each pa

3

hypotheses

Cognitive Function in Obstructive Sleep Apnea

NCT07364318 N/A Recruiting

Comenius University 30 enrolled 2024-11-01 → 2027-08-31

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and has been increasingly recognized as a contributor to cognitive decline and a potential risk factor for neurodegene

3

hypotheses

Dapagliflozin In Alzheimer's Disease

NCT03801642 Phase I Completed

Jeff Burns, MD 46 enrolled 2019-01-29 → 2022-07-07

3

hypotheses

Phase II Study Investigating the Combination of Encorafenib and Binimetinib in BRAF V600E Mutated Chinese Patients With

NCT05195632 Phase II Active

This is a phase 2, multicenter, single-arm study with a safety lead-in to investigate the efficacy, safety and pharmacokinetics of encorafenib 450 mg once daily (QD) in combination with binimetinib 45

3

hypotheses

Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock

NCT05726825 N/A Recruiting

Randomized, prospective, multicenter, open-label, controlled, parallel-group interventional trial to test the adjunctive effect of therapeutic plasma exchange in patients with early septic shock.

3

hypotheses

Effects of Pea Proteins on Muscle Damage and Recovery

NCT05657314 N/A Completed

This study is a double-blind, randomized, placebo-controlled, crossover clinical trial of N=40 recreationally active men to be recruited a single investigational center in Ohio (i.e., The Center for A

3

hypotheses

Myotonic Dystrophy Type 1 and Resistance Exercise

NCT05036447 N/A Completed

The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1. There is still doubt about if these

3

hypotheses

During-exercise Physiological Effects of Nasal High-flow in Patients With Chronic Obstructive Pulmonary Disease

NCT04014868 N/A Completed

Chronic obstructive pulmonary disease is a major cause of disability and mortality worldwide. This disease progressively leads to dyspnea and exercise capacity impairment. Pulmonary rehabilitation tea

3

hypotheses

Cilostazol in Parkinson&#39;s Disease

NCT06612593 Phase II Not Yet Recruiting

Ain Shams University 50 enrolled 2024-10-01 → 2025-10-01

Parkinson's disease is the second most common neurodegenerative diseases. The conventional treatment for PD has included dopaminergic treatment as Levodopa\\carbidopa or dopamine agonists, anti-cholin

3

hypotheses

A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Di

NCT02565511 Phase II Terminated

3

hypotheses

Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS

NCT07095712 Phase I Active

n-Lorem Foundation 1 enrolled 2024-11-25 → 2025-11

This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in

3

hypotheses

Amyotrophic Lateral Sclerosis Registry in Thailand

NCT07175935 N/A Recruiting

Chulalongkorn University 100 enrolled 2025-03-01 → 2030-12-31

This is a prospective, observational, multicenter registry designed to collect comprehensive clinical, genetic, and outcome data from patients diagnosed with amyotrophic lateral sclerosis (ALS) across

3

hypotheses

Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS

NCT05852405 N/A Completed

Ambulanzpartner Soziotechnologie APST GmbH 2,000 enrolled 2021-08-01 → 2024-12-31

Patients with sporadic ALS (sALS), which refers to those without a family history of ALS, are typically not subjected to genetic investigations as part of their standard care. Therefore, their mutatio

3

hypotheses

This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of Galunisertib (TGF-βR1/ALK5 Inhibitor)Com

NCT07321860 Phase II Not Yet Recruiting

Gipfel Life Sciences GmbH 60 enrolled 2026-06-30 → 2027-06-30

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disorder characterized by loss of upper and lower motor neurons, leading to muscle weakness, respiratory decline, an

2

hypotheses

Study of LX1001 APOE Gene Therapy in APOE4 Homozygotes

NCT03634007 Phase I Active

15 enrolled Started 2019-01-15

2

hypotheses

A Study to Evaluate the Safety and Tolerability of AL002 in AD

NCT04592874 Phase I Completed

63 enrolled Started 2020-10-01

2

hypotheses

A Study of PY314 in Subjects With Advanced Solid Tumors

NCT04691375 Phase I Terminated

Ikena Oncology 86 enrolled 2020-10-29 → 2023-08-31

This is an open-label, multicenter, first in human, Phase 1a/1b study of PY314 in subjects with locally advanced (unresectable) and/or metastatic solid tumors that are refractory or relapsed to standa

2

hypotheses

Gut Microbiota and Parkinson's Disease

NCT03710668 Unknown Unknown

Alaa E Ahmed 50 enrolled 2019-01-01 → 2020-01-01

Over the past decade, experimental data has suggested a complex and bidirectional interaction between the gastrointestinal (GI) tract and the central nervous system (CNS), the so-called "Gut- Brain ax

2

hypotheses

Colchicine for Amyotrophic Lateral Sclerosis

NCT03693781 Phase II Completed

Azienda Ospedaliero-Universitaria di Modena 54 enrolled 2019-04-10 → 2022-04-14

The study evaluates the effects of two different Colchicine doses (0.01mg/kg/day or 0.005 mg/kg/day) compared to placebo in Amyotrophic Lateral Sclerosis (ALS) patients. Disease progression as defined

2

hypotheses

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

NCT06335771 N/A Recruiting

Bettina Mittendorfer 60 enrolled 2024-08-01 → 2028-03

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The

2

hypotheses

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

NCT06571474 Unknown Recruiting

Bettina Mittendorfer 60 enrolled 2024-08-01 → 2028-03

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The

2

hypotheses

Natural History of Coronary Atherosclerosis in Real-World Stable Chest Pain Patients Underwent Computed Tomography Angio

NCT02440646 Unknown Terminated

Central Clinical Hospital of the Russian Academy o 1,080 enrolled 2015-05 → 2016-12

2

hypotheses

Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults

NCT06284720 N/A Unknown

Universidade Católica Portuguesa 16 enrolled 2024-03-01 → 2024-10-31

2

hypotheses

Suvorexant and Glymphatic Function (MRI study)

NCT03289143 Phase IV Completed

2

hypotheses

Clonal Hematopoiesis in Giant Cell Arteritis

NCT06244069 N/A Not Yet Recruiting

ASST Fatebenefratelli Sacco 326 enrolled 2024-03 → 2028-03

The goal of this clinical trial is to verify whether CHIP is correlated with the clinical, instrumental, and histological characteristics of GCA, and to characterize the pathogenetic effects of clonal

2

hypotheses

Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies

NCT03682029 N/A Active

Rigshospitalet, Denmark 109 enrolled 2017-11-21 → 2023-09-27

The primary purpose of this multi-centre, randomized, placebo-controlled, double-blind phase II study is to investigate if oral vitamin C may change the biology of low-risk myeloid malignancies; i.e.,

2

hypotheses

TET2 Mutations in Myelodysplastic Syndromes and Acute Myeloid Leukemia With Azacitidine + Ascorbic Acid

NCT03397173 Phase II Completed

Case Comprehensive Cancer Center 12 enrolled 2018-03-16 → 2021-01-03

The purpose of this study is to evaluate the efficacy of treatment with azacitidine (an FDA approved drug for the treatment of MDS) and high dose ascorbic acid in patients with TET2 mutations. This ap

2

hypotheses

Sterile Inflammation and Molecular Aberrations in MDS

NCT04313231 N/A Unknown

Medical University Innsbruck 130 enrolled 2020-01-22 → 2023-01

The objective of this study is the description of the possible association between genetic mutation/aberration profiles, inflammatory tonus and clinical phenotype based on PROMs and HRQoL. Apart from

2

hypotheses

Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau

NCT06600880 Phase I Not Yet Recruiting

2

hypotheses

ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease

NCT03739905 N/A Completed

2

hypotheses

Daridorexant to Treat Insomnia in Patients With Mild Cognitive Impairment and Mild to Moderate Alzheimer Disease

NCT05924425 Phase IV Recruiting

2

hypotheses

Daridorexant for Alzheimer Disease Prevention

NCT07213349 Phase II Recruiting

2

hypotheses

Orexin and Tau Pathology in Cognitively Normal Elderly

NCT03053908 N/A Completed

NYU Langone Health 25 enrolled 2018-03-27 → 2019-05-13

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the accumulation of amyloid plaques and neurofibrillary tangles. Current consensus is that the AD pathological process b

2

hypotheses

A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.

NCT06823752 Phase II Recruiting

Woolcock Institute of Medical Research 20 enrolled 2025-05-13 → 2026-04

The goal of this clinical trial is to explore the potential neuroprotective benefits of a dual orexin receptor antagonist (DORA) in adults with insomnia. The main questions it aims to answer are: * D

2

hypotheses

Multicenter Study on the Role of Neurodegeneration Biomarkers in Obstructive Sleep Apnea Syndrome With Residual Excessiv

NCT05795270 N/A Unknown

Istituto Auxologico Italiano 100 enrolled 2020-12-15 → 2023-08-24

Excessive daytime sleepiness which still remains after an effective treatment with nocturnal ventilotherapy or with other specific treatments (positional therapy, oro-mandibular devices) in patients w

2

hypotheses

Comparison of Different Acceleration Modes of Transcranial Magnetic Stimulation

NCT06881030 N/A Not Yet Recruiting

First Affiliated Hospital of Zhejiang University 45 enrolled 2025-03-25 → 2025-08-31

To compare the efficacy and safety of 6 times a day, 10 times a day acceleration mode and sham stimulation intervention for TRD, and to explore the antidepressant mechanism of accelerated mode, so as

2

hypotheses

Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

NCT01238250 N/A Recruiting

Simons Searchlight 100,000 enrolled 2010-10 → 2050-10

Simons Searchlight is an observational, online, international research program for families with rare genetic variants that cause neurodevelopmental disorders and may be associated with autism. Simons

2

hypotheses

BIIB078 (C9orf72 ASO) in C9-ALS

NCT03568578 Phase I Completed

2

hypotheses

Arimoclomol (HSP70 co-inducer) in ALS

NCT03491462 Phase III Completed

2

hypotheses

AL003 (Anti-SIGLEC-3/CD33) in Alzheimer's

NCT04777396 Phase I Completed

2

hypotheses

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2647544

NCT01702467 Phase I Completed

GlaxoSmithKline 72 enrolled 2012-10-01 → 2014-06-30

PLA2 enzymes (including cPLA2/PLA2G4A) generate arachidonic acid substrates for NADPH oxidases, producing reactive oxygen species that trigger PARP1 overactivation. GSK2647544's PLA2 inhibition thus i

2

hypotheses

Brain NAD in Alzheimer's Disease

NCT07127510 Unknown (Observational) Recruiting

University of Iowa 60 enrolled 2023-09-01 → 2026-08-31

Directly measures brain NAD levels in AD patients via MRS imaging. PARP1 consumes NAD+ as a substrate — overactivated PARP1 depletes neuronal NAD+ pools, causing metabolic catastrophe. This study prov

2

hypotheses

Metabolic Cofactor Supplementation in Alzheimer's and Parkinson's Disease

NCT04044131 Phase II Completed

University of Helsinki 120 enrolled 2017-01-01 → 2020-12-31

Multi-center RCT of metabolic cofactor supplementation including L-carnitine tartrate and nicotinamide riboside in AD/PD patients. These cofactors support mitochondrial energy metabolism and increase

2

hypotheses

Medium Chain Triglycerides in ALS (KETO-ALS)

NCT03690193 Phase II Completed

2

hypotheses

11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET)

NCT05608395 Phase II Completed

Masaryk Memorial Cancer Institute 33 enrolled 2020-12-04 → 2024-06-20

Glioblastoma multiforme (GBM) is the most common primary brain cancer. The treatment of GBM consists of a combination of surgery and subsequent oncological therapy, i.e. radiotherapy, chemotherapy, or

2

hypotheses

Effect of Electroacupuncture on Sensitive Symptoms of Distal Diabetic Peripheral Neuropathy

NCT05521737 N/A Recruiting

Instituto Mexicano del Seguro Social 200 enrolled 2021-11-01 → 2024-12

This is a controlled clinical trial with the aim to study the effects of electroacupuncture on neuropathic pain reduction, quality of life and changes in sensory and motor nerve conduction velocity in

2

hypotheses

Longitudinal Study of Ultra-rare Inherited Metabolic and Degenerative Neurological Diseases.

NCT04880356 N/A Recruiting

General aim of the study is the improvement of the clinical knowledge of ultra-rare inherited metabolic and degenerative neurological diseases (prevalence less than 5:100,000) in adulthood through the

2

hypotheses

Study to Evaluate the Efficacy and Safety of KDS2010 in Patients With Alzheimer's Disease With Mild Cognitive Impairment

NCT07027072 Phase II Recruiting

NeuroBiogen Co., Ltd 114 enrolled 2025-08-06 → 2027-06-30

A randomized, double-blind, placebo-controlled, dose-finding Phase 2a clinical trial will be conducted to evaluate the efficacy and safety of KDS2010 in patients with Mild Cognitive Impairment (MCI) d

2

hypotheses

Benefits of Nicotinamide Riboside Upon Cognition and Sleep

NCT05500170 N/A Recruiting

State University of New York at Buffalo 50 enrolled 2023-04-04 → 2027-08-30

Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the avail

2

hypotheses