gene

HIF1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1183Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

2Debates

Summary

HIF1A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with AD, ALI, ALS. Connected to 477 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HIF
Full Name	1α Protein
GeneCards	HIF
Human Protein Atlas	HIF
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	quercetin, rapamycin
Interactions	ABCD3, AGING, AKK, AKT, AKT1, ALS
KG Connections	1341 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure Comparison — HIF1A Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

4H6J — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q16665 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HIF1A(["HIF1A"])
    Metabolic_Reprogramming("Metabolic Reprogramming")
    IDH2["IDH2"]
    Microglial_Metabolic_Reprogramming("Microglial Metabolic Reprogramming")
    AEROBIC_GLYCOLYSIS["AEROBIC GLYCOLYSIS"]
    GLYCOLYSIS["GLYCOLYSIS"]
    Aerobic_Glycolysis["Aerobic Glycolysis"]
    BMAL1["BMAL1"]
    Bladder_Tumorigenesis("Bladder Tumorigenesis")
    Cancer_Stemness("Cancer Stemness")
    HYPOXIA["HYPOXIA"]
    STRESS_GRANULE_FORMATION["STRESS GRANULE FORMATION"]
    AKT1(["AKT1"])
    VEGF(["VEGF"])
    BNIP3(["BNIP3"])

    HIF1A -->|"associated with"| Metabolic_Reprogramming
    IDH2 -->|"associated with"| HIF1A
    HIF1A -->|"associated with"| Microglial_Metabolic_Reprogramming
    HIF1A -->|"activates"| AEROBIC_GLYCOLYSIS
    HIF1A -->|"upregulates"| GLYCOLYSIS
    HIF1A -->|"regulates"| Aerobic_Glycolysis
    BMAL1 -->|"regulates"| HIF1A
    BMAL1 -->|"interacts with"| HIF1A
    HIF1A -->|"involved in"| Bladder_Tumorigenesis
    HIF1A -->|"associated with"| Cancer_Stemness
    HIF1A -->|"mediates"| HYPOXIA
    HIF1A -->|"regulates"| STRESS_GRANULE_FORMATION
    AKT1 -->|"regulates"| HIF1A
    HIF1A -->|"regulates"| VEGF
    HIF1A -->|"activates"| BNIP3

    style HIF1A fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (676)

Target	Relation	Type	Str
HIF1A	encodes	protein	0.00
Metabolic Reprogramming	associated_with	process	0.95
Oxidative Stress	upregulates	process	0.95
cancer stemness	promotes	phenotype	0.93
lenvatinib resistance	drives	phenotype	0.91
HIF1 target genes	regulates	gene	0.90
ERRΑ	inhibits	protein	0.90
Microglial Metabolic Reprogramming	associated_with	process	0.90
NEURODEGENERATION	involved_in	disease	0.90
Metabolic Reprogramming	mediates	process	0.90
GLYCOLYSIS	upregulates	pathway	0.90
angiogenesis	promotes	process	0.90
SLC2A1	upregulates	gene	0.90
Aerobic Glycolysis	upregulates	pathway	0.90
Aerobic Glycolysis	regulates	pathway	0.90
VEGFA	upregulates	gene	0.90
AEROBIC GLYCOLYSIS	activates	entity	0.90
Proinflammatory Macrophage Activation	promotes	process	0.90
aerobic glycolysis	associated_with	process	0.90
VEGF	upregulates	gene	0.90
PFKFB3	upregulates	gene	0.88
HK2	upregulates	gene	0.88
HYPOXIA	mediates	entity	0.85
Photoreceptor Cells	causes	cell_type	0.85
STRESS GRANULE FORMATION	regulates	entity	0.85
Cancer Stemness	associated_with	phenotype	0.85
ATHEROSCLEROSIS	associated_with	disease	0.85
PARKINSON'S DISEASE	involved_in	disease	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
Oxidative Stress	regulates	process	0.85
Angiogenesis	promotes	process	0.85
Glycolysis	upregulates	pathway	0.85
Bladder Tumorigenesis	involved_in	process	0.85
Bladder Cancer	associated_with	disease	0.80
Macrophage	expressed_in	cell_type	0.80
BDNF	regulates	protein	0.80
MITOCHONDRIA	regulates	cell_type	0.80
VEGF	regulates	gene	0.80
BNIP3	activates	protein	0.80
Neuroprotection	promotes	process	0.80
MTOR	interacts_with	gene	0.80
DJ1	interacts_with	gene	0.80
ferroptosis	regulates	process	0.78
Inflammation	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Aging	therapeutic_target	disease	0.75
NLRP3	expresses	gene	0.70

Incoming (507)

Source	Relation	Type	Str
HIF1A	encodes	gene	0.00
IDH2	associated_with	entity	0.95
USP22	deubiquitinates	protein	0.95
Autophagy	degrades	process	0.95
VHL	degrades	gene	0.93
Wnt Signaling	activates	pathway	0.90
SIRT3	inhibits	gene	0.90
h-646ae8f1	targets	hypothesis	0.90
UBIQUITIN	modulates	protein	0.90
hypoxia	associated_with	gene	0.90
BMAL1	interacts_with	entity	0.90
ERRΑ	stabilizes	protein	0.90
BMAL1	regulates	gene	0.90
JAK1/STAT1/3	activates	pathway	0.90
Pi3K/Akt Pathway	regulates	pathway	0.85
APOE4 Microglia	upregulates	cell_type	0.85
cardamom nanoemulsion	downregulates	compound	0.85
AKT1	regulates	protein	0.85
PI3K/AKT	regulates	pathway	0.85
PI3K/Akt	activates	pathway	0.85
HV1	upregulates	gene	0.85
HVCN1	upregulates	gene	0.85
PIK3CA	activates	gene	0.82
AKT1	activates	gene	0.82
PDI	activates	protein	0.80
EGLN2	inhibits	gene	0.80
NLRP3 inhibition	contributes_to	phenotype	0.80
FOXO3	interacts_with	protein	0.75
GASDERMIN	activates	gene	0.70
GPX4	activates	gene	0.70
ACHE	activates	gene	0.70
DBH	activates	gene	0.70
APOE	expresses	gene	0.70
CAT	targets	gene	0.70
BAX	activates	gene	0.70
nAChR-α7	associated_with	gene	0.70
NF-κB	activates	gene	0.70
acetylcholine	activates	gene	0.70
TNF	associated_with	gene	0.70
APOPTOSIS	activates	gene	0.70
acetylcholine	enhances	gene	0.70
IL6	activates	gene	0.70
nAChR-alpha7	activates	gene	0.70
BAX	inhibits	gene	0.70
BCL2	inhibits	gene	0.70
FRONTOTEMPORAL DEMENTIA	causes	disease	0.65
ATP	activates	gene	0.65
AMYLOID	interacts_with	protein	0.65
sorafenib	regulates	drug	0.64
STAT1	activates	protein	0.64

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HIF1A stabilization lowers the activation threshold of circa	0.566	neuroinflammation	Do microglia actually switch between gly
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Chromatin accessibility profiling (ATAC-seq) revealed unique chromatin	computational	Parkinson's disease	0.500	0.00	postmortem_human_tissue	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 4 · Score: 0.86 · 2026-04-12

Investigate mechanistic links between early microglial priming states, neuroinfl

closed · Rounds: 5 · Score: 0.95 · 2026-04-12

Related Research

Hypotheses and analyses mentioning HIF1A in their description or question text

No additional research found

HIF1A

Understanding Entity Pages

Summary

Wiki Pages (3)

HIF-1α Protein

HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor

HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha

Pathway Diagram

Outgoing (676)

Incoming (507)

Targeting Hypotheses (2)

Mentioning Analyses (1)

Neuroinflammation and microglial priming in early Alzheimer's Disease

Experiments (1)

Related Papers (0)

Debates (2)

Investigate mechanistic links between early microglial priming states, neuroinfl

Investigate mechanistic links between early microglial priming states, neuroinfl

Related Research