gene

ERN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

981Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for ERN1 — Endoplasmic Reticulum To Nucleus Signaling 1

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🧬 Gene Info

Gene Symbol	ERN1
Full Name	Endoplasmic Reticulum To Nucleus Signaling 1
Chromosome	6p24.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	1210 aa
Exons	54
Pathways	Akt, Apoptosis, Wnt
GeneCards	ERN1
Human Protein Atlas	ERN1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, ACETYL-COA, Actin, AKT, AKT1, AKT1S1
KG Connections	981 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ERN1["ERN1"] -->|"activates"| autophagy["autophagy"]
    ERN1["ERN1"] -->|"interacts with"| Dementia["Dementia"]
    ERN1["ERN1"] -->|"interacts with"| Cardiovascular["Cardiovascular"]
    ERN1["ERN1"] -->|"interacts with"| Als["Als"]
    ERN1["ERN1"] -->|"interacts with"| Alzheimer["Alzheimer"]
    ERN1["ERN1"] -->|"interacts with"| Parkinson["Parkinson"]
    ERS["ERS"] -->|"activates"| ERN1["ERN1"]
    CAT["CAT"] -->|"interacts with"| ERN1["ERN1"]
    OPTN["OPTN"] -->|"interacts with"| ERN1["ERN1"]
    DNM1L["DNM1L"] -->|"interacts with"| ERN1["ERN1"]
    style ERN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (622)

Target	Relation	Type	Str
MTORC1	activates	protein	0.85
autophagy	activates	process	0.84
AUTOPHAGY	activates	pathway	0.84
neural stem cells	regulates	cell_type	0.80
neural stem cells	activates	cell_type	0.80
NLR	regulates	gene	0.80
autophagy pathway	participates_in	pathway	0.80
NLR	activates	gene	0.80
SQSTM1	regulates	gene	0.80
ROS	activates	gene	0.80
necroptosis	participates_in	pathway	0.80
MAPK signaling	participates_in	pathway	0.80
LC3	regulates	gene	0.80
oxidative stress response	participates_in	pathway	0.80
ROS	regulates	gene	0.80
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
unfolded protein response	participates_in	pathway	0.70
Er Stress	activates	pathway	0.70
STAT3	regulates	gene	0.70
MAPK	regulates	gene	0.70
MTOR	regulates	gene	0.70
dendritic cells	regulates	cell_type	0.70
dendritic cells	activates	cell_type	0.70
RB1	regulates	gene	0.70
PI3K	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
RIPK3	regulates	gene	0.70
NLRP3	regulates	gene	0.70
NBR1	regulates	gene	0.70
OPTN	regulates	gene	0.70
STAT3	activates	gene	0.70
MTOR	activates	gene	0.70
RB1	activates	gene	0.70
PI3K	activates	gene	0.70
FIP200	regulates	gene	0.70
EIF2AK3	activates	gene	0.70
Autophagy	activates	pathway	0.70
NRBF2	activates	gene	0.70
JNK	regulates	gene	0.70
STING1	regulates	gene	0.70
JAK-STAT signaling	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
Alzheimer	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	interacts_with	disease	0.65

Incoming (359)

Source	Relation	Type	Str
Endoplasmic Reticulum Stress	activates	process	0.90
EIF2AK3	regulates	gene	0.80
DNA	activates	gene	0.70
ATG	activates	gene	0.70
DNA	regulates	gene	0.70
BECN1	regulates	gene	0.70
DDIT3	regulates	gene	0.70
ATG	regulates	gene	0.70
rapamycin	targets	drug	0.70
ERS	activates	pathway	0.64
BIM	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ATF4	activates	gene	0.60
DDIT3	activates	gene	0.60
XBP1	activates	gene	0.60
ATF6	activates	gene	0.60
RICTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
EIF2AK3	inhibits	entity	0.60
CANCER	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
ATP	activates	gene	0.60
NRBF2	interacts_with	gene	0.60
ASC	activates	gene	0.60
BRG1	activates	gene	0.60
ASC	regulates	gene	0.60
ROS	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
apoptosis	inhibits	pathway	0.60
SQSTM1	associated_with	gene	0.60
AMPK	regulates	gene	0.60
PI3K	associated_with	gene	0.60
BCL2	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ALS	regulates	gene	0.60
NLRP3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERN1 in their description or question text

No additional research found