gene

SESN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SESN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

551Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SESN2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 257 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SESN2
Full Name	Sestrin 2
Chromosome	1p35.3
Protein Family	Sestrin family (SESN1-3)
Function	is a stress-inducible protein that functions as a critical regulator of cellular homeostasis, metabolic adaptation, and stress resistance [1].
Molecular Weight	57 kDa
Amino Acids	504 aa
Pathways	signaling: ```mermaid, mTOR, mtor, AMPK, AMPK signaling
UniProt ID	Q9Y7X7
NCBI Gene ID	83667
Ensembl ID	ENSG00000140299
OMIM	607336
GeneCards	SESN2
Human Protein Atlas	SESN2
N-terminal domain (1-170)	Leucine-rich repeat (LRR) motif for protein-protein interactions
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	551 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SESN2 — AlphaFold Q9Y7X7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SESN2 Gene

gene · 1337 words

→

SESN2 Protein

protein · 1133 words

→

Pathway Diagram

graph TD
    SESN2["SESN2"] -->|"Associated With"| Alzheimer_s_disease["Alzheimer's disease"]
    SESN2["SESN2"] -->|"Interacts With"| Dementia["Dementia"]
    SESN2["SESN2"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    SESN2["SESN2"] -->|"Interacts With"| Als["Als"]
    SESN2["SESN2"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    SESN2["SESN2"] -->|"Interacts With"| Parkinson["Parkinson"]
    SESN2["SESN2"] -->|"Interacts With"| Ms["Ms"]
    SESN2["SESN2"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CAT["CAT"] -->|"Interacts With"| SESN2["SESN2"]
    OPTN["OPTN"] -->|"Interacts With"| SESN2["SESN2"]
    DNM1L["DNM1L"] -->|"Interacts With"| SESN2["SESN2"]
    CANX["CANX"] -->|"Interacts With"| SESN2["SESN2"]
    LGALS3["LGALS3"] -->|"Interacts With"| SESN2["SESN2"]
    style SESN2 fill:#8d4900,color:#e0e0e0
    style Alzheimer_s_disease fill:#b71c1c,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (243)

Target	Relation	Type	Str
PRKAA1	regulates	gene	0.95
NFE2L2	regulates	gene	0.95
KEAP1	regulates	gene	0.95
Alzheimer's disease	associated_with	disease	0.70
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Infection	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	activates	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Cardiac	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Chemoresistance	inhibits	pathway	0.60
Parkinson's disease	activates	disease	0.60
Alzheimer's disease	activates	disease	0.60
ALS	activates	disease	0.60
frontotemporal dementia	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
ULK1	associated_with	gene	0.60
TRAF2	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
dementia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60
neurons	expressed_in	cell_type	0.60
SNCA	interacts_with	gene	0.60
STX17	associated_with	gene	0.60
MAVS	associated_with	gene	0.60
IKBKE	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
BNIP3L	associated_with	gene	0.60

Incoming (308)

Source	Relation	Type	Str
Rhoifolin	upregulates	compound	0.90
BECN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
CTSD	activates	entity	0.60
BCL2	associated_with	gene	0.60
FUNDC1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
TNF	associated_with	gene	0.60
FIS1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BCL2L13	associated_with	gene	0.60
MFF	associated_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
PRKN	associated_with	gene	0.60
MTOR	activates	gene	0.60
EIF2S1	activates	entity	0.60
MDM2	activates	gene	0.60
SIRT1	activates	gene	0.60
ABCD3	activates	entity	0.60
HMOX1	expressed_in	gene	0.60
AMPK	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AMBRA1	activates	entity	0.60
ATM	activates	entity	0.60
PHB2	activates	gene	0.60
RB1	activates	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SESN2 in their description or question text

No additional research found