concept

PROTEINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1214Connections

5Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

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💡 Concept Info

Name	PROTEINS
Related Diseases	APOPTOSIS, LATE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

G Proteins

mechanism · 1607 words

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Pathway Diagram

graph TD
    PROTEINS["PROTEINS"]
    style PROTEINS fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PROTEINS -->|"involved_in"| Age_Related_Disease_Risk(Age-Related Disease Risk)
    PROTEINS -->|"regulates"| APOPTOSIS(APOPTOSIS)
    PROTEINS -->|"references"| SIRT6([SIRT6])
    PROTEINS -->|"references"| MMP2([MMP2])
    PROTEINS -->|"references"| PYCARD([PYCARD])
    PROTEINS -->|"references"| HNRNPA2B1([HNRNPA2B1])
    PROTEINS -->|"references"| AQP4([AQP4])
    PROTEINS -->|"references"| COX4I1([COX4I1])
    PROTEINS -->|"references"| HSPA1A([HSPA1A])
    PROTEINS -->|"references"| CREB1([CREB1])
    ROS(ROS) -->|"causes"| PROTEINS

Outgoing (113)

Target	Relation	Type	Str
Age-Related Disease Risk	involved_in	phenotype	0.90
Mortality Risk	risk_factor_for	phenotype	0.85
Disease Risk	risk_factor_for	phenotype	0.85
Prostate Cancer Biomarkers	associated_with	biomarker	0.80
APOPTOSIS	regulates	phenotype	0.64
WNT SIGNALING	inhibits	concept	0.50
STRESS GRANULES	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
α-SYNUCLEIN	interacts_with	concept	0.50
STRESS GRANULES	associated_with	concept	0.50
GSK3	activates	concept	0.50
PI3K/AKT SIGNALING	activates	concept	0.50
PEROXISOME	activates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	interacts_with	concept	0.50
SELECTIVE AUTOPHAGY	activates	concept	0.50
AUTOPHAGOSOME	regulates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50
AMYLOID-β	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
AUTOPHAGOSOME	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	interacts_with	concept	0.50
CX43	expressed_in	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
B CELLS	interacts_with	concept	0.50
FIBROBLASTS	activates	concept	0.50
ENDOPLASMIC RETICULUM	regulates	concept	0.50
GENE EXPRESSION	activates	concept	0.50
CEREBROSPINAL FLUID	interacts_with	concept	0.50
B CELLS	inhibits	concept	0.50
RAPAMYCIN	activates	concept	0.50
METFORMIN	associated_with	concept	0.50
METFORMIN	inhibits	concept	0.50
GLIOSIS	activates	concept	0.50
GENE EXPRESSION	inhibits	concept	0.50
Neuroprotection	activates	process	0.50
α-SYNUCLEIN	activates	concept	0.50
LEWY BODY	inhibits	concept	0.50
AMYGDALA	associated_with	concept	0.50
AMYGDALA	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
SELECTIVE AUTOPHAGY	regulates	concept	0.50
AMYLOID-β	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
NUCLEUS	associated_with	concept	0.50
Cognitive Decline	associated_with	disease	0.50
ISCHEMIC STROKE	expressed_in	concept	0.50

Incoming (1101)

Source	Relation	Type	Str
ROS	causes	phenotype	0.64
SDC1	expressed_in	concept	0.50
SYNCRIP	interacts_with	concept	0.50
TFEB	activates	protein	0.50
ATG12	activates	gene	0.50
ATG10	activates	gene	0.50
HSPB8	activates	gene	0.50
PPARGC1A	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
MCOLN1	activates	gene	0.50
BAG3	activates	gene	0.50
TREH	activates	gene	0.50
Autophagy	activates	process	0.50
CTSB	activates	gene	0.50
LAMP2A	activates	gene	0.50
TPP1	activates	gene	0.50
PPP3	activates	concept	0.50
TREHALOSE	activates	concept	0.50
MCOLN1	inhibits	gene	0.50
STX17	inhibits	gene	0.50
VAMP8	inhibits	gene	0.50
SNARE	inhibits	protein	0.50
LYSOSOME	inhibits	gene	0.50
Calcium Signaling	regulates	pathway	0.50
SYNCRIP	activates	concept	0.50
CDC42	associated_with	gene	0.50
SYNCRIP	associated_with	concept	0.50
Neurogenesis	interacts_with	pathway	0.50
TGM2	associated_with	gene	0.50
TARDBP	associated_with	gene	0.50
PTBP1	associated_with	gene	0.50
HNRNPA1	associated_with	gene	0.50
HNRNPK	associated_with	gene	0.50
CHIP	activates	protein	0.50
cancer	activates	disease	0.50
disease	activates	disease	0.50
MAP2	interacts_with	gene	0.50
MAP1B	interacts_with	gene	0.50
MAP6	interacts_with	gene	0.50
MAP6	regulates	gene	0.50
Neuron	interacts_with	cell_type	0.50
MICROTUBULES	interacts_with	concept	0.50
Neuron	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
GLUT4	activates	concept	0.50
INSULIN	activates	concept	0.50
NUDEL	interacts_with	protein	0.50
TGM2	expressed_in	gene	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.621	neurodegeneration	Mitochondrial transfer between astrocyte
Sulfated glycans and metal-binding CSF proteins brace alpha-	0.489	neurodegeneration	Which specific CSF molecular components
RNA-binding proteins stabilize or gate the lncRNA-0021:mmu-m	0.480	molecular neurobiology	How does lncRNA-0021 achieve sequence-sp
CHIP E3 Ligase Enhancement to Target Synaptic Proteins for D	0.472	proteomics	Quantitative proteomics of the aging syn
Alectinib Binds Mitochondrial C1q-like Proteins (C1QDC1) Rat	0.122	molecular biology	Does Alectinib truly bind C1q directly w

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AAV-LRRK2 IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Axonal Transport Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
AAV-LRRK2 Gene Therapy IND-Enabling Study Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson'	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Therapeutic developments in pancreatic cancer. [PMID:37798442]	["Hu Z", "O'Reilly E"]	Nature reviews. Gastroenterolo	2024	0
Defining treatment-resistant depression. [PMID:31638723]	["Gaynes B", "Lux L", "Gartlehner G", "A	Depression and anxiety	2020	0
Emerging trends in global freshwater availability. [PMID:29769728]	["Rodell M", "Famiglietti J", "Wiese D",	Nature	2018	0
Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969]	["Kurmani S", "Squire I"]	Current heart failure reports	2017	0
Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335]	["Aquino R", "Vasques P", "Cavalcante D"	Revista do Colegio Brasileiro	2017	0
The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062]	["Kane J", "Johnson R", "Robinson C", "J	The Journal of adolescent heal	2016	0
A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607]	["Naqvi N", "Li M", "Calvert J", "Tejada	Cell	2014	0
Family medicine match rate increases slightly. [PMID:22585896]	Sheri Porter	Annals of family medicine	2012	0
Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899]	["Pivac N", "Knezevi\u0107 A", "Gornik O	Molecular & cellular proteomic	2011	0
The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503]	["Bulgakova N", "Knust E"]	Journal of cell science	2009	0
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423]	["Landsman L", "Bar-On L", "Zernecke A",	Blood	2009	0
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324]	Brickley K, Smith MJ, Beck M, Stephenson	The Journal of biological chem	2005	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PROTEINS in their description or question text

No additional research found