gene

ALZHEIMER DISEASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALZHEIMER DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1800Connections

1Hypotheses

10Analyses

50Outgoing

50Incoming

0Experiments

12Debates

Summary

ALZHEIMER DISEASE is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with ALS, Aging, Als. Connected to 753 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ALZHEIMER DISEASE
Primary Expression	Ca1, Cortex, Hippocampus
Pathways	Autophagy, Oxidative Stress, Stem Cell, Complement, Immune Response
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Atherosclerosis
Known Drugs/Compounds	ANTI-AΒ ANTIBODIES, ds-cRNA
Interactions	ABCA1, ABCD3, ABI3, ACE, ACHE, ADAM10
KG Connections	1334 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Ms["Ms"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Cancer["Cancer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"therapeutic target"| Diabetes["Diabetes"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| Alzheimer_1["Alzheimer"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"activates"| Anxiety["Anxiety"]
    TREM2["TREM2"] -->|"associated"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    AKT1["AKT1"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    EGFR["EGFR"] -->|"therapeutic target"| ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    style ALZHEIMER_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (943)

Target	Relation	Type	Str
Als	associated_with	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Dementia	biomarker_for	disease	1.00
Alzheimer	activates	disease	1.00
Als	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
Aging	associated_with	disease	1.00
Alzheimer	biomarker_for	disease	0.95
Parkinson	associated_with	disease	0.95
Neurodegeneration	biomarker_for	disease	0.95
Molecular Heterogeneity	associated_with	process	0.95
Inflammation	associated_with	disease	0.95
Neurodegeneration	therapeutic_target	disease	0.95
ANTI-AΒ ANTIBODIES	targets	drug	0.90
APOE4	markers	protein	0.90
TREM2	associated_with	gene	0.90
PSEN1	associated_with	gene	0.90
P-Tau	markers	protein	0.90
Amyloid Beta 42/40	markers	protein	0.90
Premature Senescence	causes	phenotype	0.90
Autophagy	activates	pathway	0.90
ALZHEIMER	associated_with	gene	0.90
APOE	activates	gene	0.90
ALZHEIMER	activates	gene	0.90
DEMENTIA	biomarker_for	gene	0.90
Als	biomarker_for	disease	0.85
Cancer	associated_with	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Aging	activates	disease	0.85
Dementia	associated_with	disease	0.85
Neurodegeneration	activates	disease	0.85
Neuroinflammation	associated_with	disease	0.85
Obesity	associated_with	disease	0.85
Neurodegeneration	inhibits	disease	0.85
Alzheimer	causes	disease	0.85
Blood-Brain Barrier Dysfunction	associated_with	phenotype	0.85
Aging	biomarker_for	disease	0.85
CD2AP	associated_with	gene	0.80
BLNK	associated_with	gene	0.80
SORL1	associated_with	gene	0.80
CD33	associated_with	gene	0.80
PLCG2	associated_with	gene	0.80
CTSH	associated_with	gene	0.80
Neuroinflammation	disrupts	pathway	0.80
ACE	associated_with	gene	0.80
GRN	associated_with	gene	0.80
Cognitive Status	disrupts	pathway	0.80
INPP5D	associated_with	gene	0.80

Incoming (857)

Source	Relation	Type	Str
ALZHEIMER	therapeutic_target	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
ALZHEIMER	activates	gene	1.00
TAU	associated_with	gene	1.00
AUTOPHAGY	activates	gene	1.00
AMYLOID	activates	gene	1.00
AGING	associated_with	gene	1.00
Blood Test	biomarker_for	biomarker	0.98
Amyloid Probability Score 2	biomarker_for	biomarker	0.98
Donanemab	treats	drug	0.95
Amyloid Reduction	therapeutic_target	mechanism	0.95
Amyloid-Beta 42	biomarker_for	protein	0.95
Aβ42:Aβ40 Ratio	biomarker_for	biomarker	0.95
MAPT	biomarker_for	protein	0.95
Amyloid-Beta 40	biomarker_for	protein	0.95
Neuroinflammation	associated_with	process	0.95
APOE ε4	risk_factor_for	protein	0.95
APOE	associated_with	gene	0.95
Phosphorylated Tau at Threonine 181	biomarker_for	biomarker	0.95
Γ-SECRETASE	involved_in	enzyme	0.95
Amyloid-Beta Accumulation	contributes_to	phenotype	0.95
Amyloid-β Accumulation	contributes_to	phenotype	0.95
APOE ε4 Allele	risk_factor_for	biomarker	0.95
Amyloid-β	biomarker_for	biomarker	0.95
Mitochondrial Dysfunction	contributes_to	process	0.95
APOE*ε4	risk_factor_for	biomarker	0.95
Macrophages	contributes_to	cell_type	0.95
P-Tau217	biomarker_for	biomarker	0.95
TAU	associated_with	protein	0.95
Oxidative Stress	contributes_to	process	0.95
Cellular Senescence	contributes_to	process	0.95
Microglia	contributes_to	cell_type	0.95
Immune Activation	contributes_to	process	0.95
TAU	biomarker_for	protein	0.95
BETA-AMYLOID	biomarker_for	protein	0.95
Phosphorylated Tau 217	biomarker_for	biomarker	0.95
Microglial Phagocytosis	causes	process	0.95
Anti-Aβ Antibodies	treats	drug	0.95
Amyloid-Beta Plaque Deposition	biomarker_for	biomarker	0.95
Amyloid-beta	biomarker_for	biomarker	0.95
APOE	protects_against	gene	0.95
Neuritic Plaques	associated_with	phenotype	0.95
MAPT	causes	gene	0.95
Neurofibrillary Tangles	associated_with	phenotype	0.95
AMYLOID BETA	involved_in	protein	0.95
ISG15	implicated_in	gene	0.95
AMYLOID-Β	associated_with	protein	0.95
Ageing	risk_factor_for	process	0.95
AMYLOID-BETA	associated_with	protein	0.95

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-driven loss of neuronal PI(4,5)P2 bridges ganglioside-	0.380	Alzheimer disease	Lipid metabolism dysregulation and membr

Mentioning Analyses (10)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (12)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning ALZHEIMER DISEASE in their description or question text

No additional research found

ALZHEIMER DISEASE

Understanding Entity Pages

Summary

Pathway Diagram

Outgoing (943)

Incoming (857)

Targeting Hypotheses (1)

Mentioning Analyses (10)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

Allen Mouse Brain Aging Atlas: cross-age gene expression analysis

Gene Regulatory Network Inference in Alzheimer's Disease

Statistical Fine-Mapping of AD GWAS Loci to Identify Causal Variants

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

Why have numerous phase 3 clinical trials failed despite advances in understandi

What are the optimal temporal windows for TREM2 inhibition vs activation in Alzh

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Selective vulnerability of entorhinal cortex layer II neurons in AD

Experiments (0)

Related Papers (0)

Debates (12)

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

How does gene expression change across age groups (young/middle/old) in hippocam

The debate proposed biphasic TREM2 modulation but couldn't define when to switch

How do metabolomic alterations in glucose metabolism, mitochondrial function, an

Can Bayesian fine-mapping of the top 25 AD GWAS loci identify credible sets of c

Which transcription factors drive the gene regulatory networks that distinguish

Is REST the master regulator of neuronal vulnerability in AD, or is it one of se

Does fine-mapping to median 3-variant credible sets provide sufficient resolutio

The abstract shows that Gal3 binding to pTau greatly enhances tau fibrillation,

Why have numerous phase 3 clinical trials failed despite advances in understandi

Related Research