gene

DISC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DISC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

763Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DISC1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, regulates. Associated with AD, ALI, ALS. Connected to 408 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DISC1
Full Name	Disrupted in Schizophrenia 1
Chromosome	1q42.2
Protein Type	Scaffold Protein
Function	Centrosomal function: DISC1 localizes to the centrosome where it interacts with NDEL1, LIS1, and dynein to regulate neuronal migration during cortical development
Primary Expression	Hippocampus, Cerebral cortex, Cerebellum, Dentate gyrus
Exons	13
Pathways	Akt, Apoptosis, Complement, Exocytosis, Mitochondrial Function
UniProt ID	Q9NRI5
NCBI Gene ID	27185
Ensembl ID	ENSG00000162946
OMIM	605210
GeneCards	DISC1
Human Protein Atlas	DISC1
Associated Diseases	AD, ALI, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	763 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DISC1 — AlphaFold Q9NRI5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DISC1 — Disrupted in Schizophrenia 1

gene · 1334 words

→

DISC1 Protein

protein · 1045 words

→

Pathway Diagram

graph TD
    DISC1["DISC1"] -->|"Interacts With"| Dementia["Dementia"]
    DISC1["DISC1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    DISC1["DISC1"] -->|"Interacts With"| Als["Als"]
    DISC1["DISC1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    DISC1["DISC1"] -->|"Interacts With"| Parkinson["Parkinson"]
    DISC1["DISC1"] -->|"Interacts With"| Ms["Ms"]
    DISC1["DISC1"] -->|"Associated With"| Schizophrenia["Schizophrenia"]
    DISC1["DISC1"] -->|"Associated With"| Depression["Depression"]
    CAT["CAT"] -->|"Interacts With"| DISC1["DISC1"]
    OPTN["OPTN"] -->|"Interacts With"| DISC1["DISC1"]
    DNM1L["DNM1L"] -->|"Interacts With"| DISC1["DISC1"]
    CANX["CANX"] -->|"Interacts With"| DISC1["DISC1"]
    LGALS3["LGALS3"] -->|"Interacts With"| DISC1["DISC1"]
    style DISC1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Schizophrenia fill:#b71c1c,color:#e0e0e0
    style Depression fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (479)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.70
schizophrenia	interacts_with	disease	0.70
Bipolar Disorder	associated_with	disease	0.70
Autism	activates	disease	0.65
Ms	regulates	disease	0.65
Traumatic Brain Injury	interacts_with	disease	0.65
Bipolar	expressed_in	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Ms	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Autism	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Als	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Bipolar	regulates	disease	0.65
Als	expressed_in	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Depression	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Depression	regulates	disease	0.65
Aging	expressed_in	disease	0.65
Bipolar	interacts_with	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Autism	regulates	disease	0.65
Als	regulates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Schizophrenia	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Depression	activates	disease	0.65
Bipolar	activates	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Schizophrenia	inhibits	disease	0.65
Ms	associated_with	disease	0.65

Incoming (284)

Source	Relation	Type	Str
BCL2L11	activates	entity	0.60
BNIP3L	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CANX	activates	entity	0.60
CAT	activates	entity	0.60
CHOP	activates	entity	0.60
CTSD	activates	entity	0.60
TRAF2	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
ATM	regulates	gene	0.60
BCL2	regulates	gene	0.60
BCL2L13	regulates	gene	0.60
BECN1	regulates	gene	0.60
BNIP3	regulates	gene	0.60
BNIP3L	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CAT	regulates	gene	0.60
CHOP	regulates	gene	0.60
CTSD	regulates	gene	0.60
DDIT3	regulates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AXIN	therapeutic_target	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
DDIT3	activates	entity	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
BCL2	activates	entity	0.60
BCL2L13	activates	entity	0.60
BECN1	activates	entity	0.60
BNIP3	activates	entity	0.60
TCF3	therapeutic_target	gene	0.60
NDEL1	interacts_with	gene	0.60
LIS1	interacts_with	gene	0.60
GRM3	regulates	gene	0.60
APP	expressed_in	gene	0.60
NTRK2	interacts_with	gene	0.60
SRC	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DISC1 in their description or question text

No additional research found