gene

ABCD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

470Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ABCD3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, regulates. Associated with AD, ALI, ALS. Connected to 242 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ABCD3
Chromosome	1p22.1
Protein Family	ABC transporter subfamily D
Protein Type	Transporter
Function	ABCD3 functions as a peroxisomal membrane transporter
Primary Expression	multiple tissues, with highest levels in liver, kidney, and brain
Subcellular Localization	Peroxisomal membrane
Molecular Weight	79.7 kDa
Pathways	Tgf-Beta, Wnt
UniProt ID	[O75323](https://www.uniprot.org/uniprot/O75323)
GeneCards	ABCD3
Human Protein Atlas	ABCD3
Associated Diseases	AD, ALI, Als, Alzheimer, Cancer
Interactions	ABCD1, ABCD2, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	470 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABCD3 Gene

gene · 670 words

→

ABCD3 Protein

protein · 590 words

→

Pathway Diagram

graph TD
    ABCD3["ABCD3"] -->|"interacts"| Dementia["Dementia"]
    ABCD3["ABCD3"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    ABCD3["ABCD3"] -->|"interacts"| Als["Als"]
    ABCD3["ABCD3"] -->|"interacts"| Alzheimer["Alzheimer"]
    ABCD3["ABCD3"] -->|"interacts"| Parkinson["Parkinson"]
    ABCD3["ABCD3"] -->|"interacts"| Ms["Ms"]
    CAT["CAT"] -->|"interacts"| ABCD3["ABCD3"]
    OPTN["OPTN"] -->|"interacts"| ABCD3["ABCD3"]
    DNM1L["DNM1L"] -->|"interacts"| ABCD3["ABCD3"]
    CANX["CANX"] -->|"interacts"| ABCD3["ABCD3"]
    style ABCD3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (371)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Ftd	interacts_with	disease	0.65
Diabetes	regulates	disease	0.65
Ms	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	expressed_in	disease	0.65
Hypertension	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	associated_with	disease	0.65
Tumor	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
JNK	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
PHB2	interacts_with	gene	0.60
Rb	interacts_with	protein	0.60
PGAM5	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
ABCD1	associated_with	gene	0.60
ABCD2	associated_with	gene	0.60
Apoptosis	interacts_with	pathway	0.60
Mitophagy	interacts_with	pathway	0.60
Autophagy	interacts_with	pathway	0.60
FIP200	interacts_with	gene	0.60

Incoming (99)

Source	Relation	Type	Str
genes-abcd3	describes	wiki_page	0.95
LC3B	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABCD3 in their description or question text

No additional research found