gene

MFN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

924Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MFN1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 397 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MFN1
Chromosome	3q26.33
Function	Mitofusin 1 (MFN1) is a dynamin-like GTPase essential for mitochondrial outer membrane fusion
Primary Expression	hippocampus, Cerebellum, Cortex, Striatum, Substantia Nigra
Molecular Weight	83 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Lysosomal Degradation, Mitochondrial Function
GeneCards	MFN1
Human Protein Atlas	MFN1
Associated Diseases	AD, ALI, Als, Alzheimer, COPD
Interactions	ABCD3, Actin, AGING, AKT, ALS, ALZHEIMER
KG Connections	924 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFN1["MFN1"] -->|"Interacts With"| Dementia["Dementia"]
    MFN1["MFN1"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    MFN1["MFN1"] -->|"Interacts With"| Als["Als"]
    MFN1["MFN1"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    MFN1["MFN1"] -->|"Interacts With"| Parkinson["Parkinson"]
    MFN1["MFN1"] -->|"Interacts With"| Ms["Ms"]
    MFN1["MFN1"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MFN1["MFN1"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| MFN1["MFN1"]
    OPTN["OPTN"] -->|"Interacts With"| MFN1["MFN1"]
    DNM1L["DNM1L"] -->|"Interacts With"| MFN1["MFN1"]
    CANX["CANX"] -->|"Interacts With"| MFN1["MFN1"]
    LGALS3["LGALS3"] -->|"Interacts With"| MFN1["MFN1"]
    style MFN1 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (527)

Target	Relation	Type	Str
mitochondrial fusion	promotes	process	0.95
Mitochondrial fusion	activates	process	0.90
Mitochondrial Fusion	mediates	process	0.88
mitochondrial fusion	involved_in	process	0.85
Mitochondrial Fusion	promotes	process	0.85
autophagy	regulates	process	0.85
nutrient deprivation	modulates	process	0.80
Inflammation	activates	disease	0.75
Als	activates	disease	0.75
Als	expressed_in	disease	0.75
MITOPHAGY	activates	gene	0.70
Mitophagy	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
OXIDATIVE STRESS	activates	gene	0.70
TFAM	activates	gene	0.70
OPA1	inhibits	gene	0.70
mitochondrial dynamics	participates_in	pathway	0.70
Als	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Huntington	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Ms	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	associated_with	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Parkinson	activates	disease	0.65
Ischemia	regulates	disease	0.65
Stroke	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Hypertension	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Aging	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65

Incoming (397)

Source	Relation	Type	Str
Paclitaxel	downregulates	drug	0.85
PM10	downregulates	compound	0.85
MFN2	inhibits	gene	0.70
PARKIN	modifies	gene	0.70
NEURONS	inhibits	cell_type	0.70
Copper	inhibits	drug	0.70
TAX1BP1	interacts_with	gene	0.60
CTSD	regulates	gene	0.60
STING1	interacts_with	gene	0.60
EIF2AK3	regulates	gene	0.60
FIP200	regulates	gene	0.60
LMNA	regulates	gene	0.60
DDIT3	regulates	gene	0.60
G3BP1	regulates	gene	0.60
MAP1LC3	activates	gene	0.60
HIF1A	regulates	gene	0.60
JNK	regulates	gene	0.60
LC3	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
AMPK	therapeutic_target	gene	0.60
MAP1LC3B	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
FUNDC1	regulates	gene	0.60
LC3B	activates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
DISC1	regulates	gene	0.60
CHOP	regulates	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
ALS	activates	entity	0.60
AMPK	activates	entity	0.60
FTD	activates	entity	0.60
LGALS3	regulates	gene	0.60
ERN1	regulates	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MITOPHAGY	activates	gene	0.60
PARKINSON	activates	gene	0.60
CAT	regulates	gene	0.60
ERK1/2	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MFN1 in their description or question text

No additional research found