protein

TIA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TIA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

256Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TIA1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Aging, Als. Connected to 136 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	TIA1
Aliases	Page for TIA1
Chromosome	2p16.3
Protein Family	TIA1/TIAR family
Function	TIA1 functions as a multifunctional RNA-binding protein with critical roles in several cellular processes.
Subcellular Localization	</strong></td><td>Cytoplasm, stress granules</td></tr>
Molecular Weight	43 kDa
Amino Acids	386 aa
Pathways	Er Stress
UniProt ID	P52912
NCBI Gene ID	4678
Ensembl ID	ENSG00000173166
OMIM	603518
GeneCards	TIA1
Human Protein Atlas	TIA1
Associated Diseases	Als, amyotrophic lateral sclerosis, dementia
Known Drugs/Compounds	rapamycin
Interactions	ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOPTOSIS
KG Connections	256 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TIA1 — AlphaFold P52912 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TIA1["TIA1"]
    TIA1 -->|"regulates"| stress_granules["stress granules"]
    TIA1 -->|"inhibits"| HSP70["HSP70"]
    TIA1 -->|"activates"| motor_neurons["motor neurons"]
    TIA1 -->|"interacts"| Cancer["Cancer"]
    TIA1 -->|"interacts"| Aging["Aging"]
    TIA1 -->|"interacts"| Ms["Ms"]
    TIA1 -->|"interacts"| Als["Als"]
    TIA1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    RRAGA["RRAGA"] -->|"interacts"| TIA1
    JUN["JUN"] -->|"interacts"| TIA1
    MAPT["MAPT"] -->|"interacts"| TIA1
    RRAGB["RRAGB"] -->|"interacts"| TIA1
    VCP["VCP"] -->|"contributes to"| TIA1
    SQSTM1["SQSTM1"] -->|"contributes to"| TIA1
    RANK["RANK"] -->|"activates"| TIA1
    RANKL["RANKL"] -->|"activates"| TIA1
    GAIN["GAIN"] -->|"activates"| TIA1

Outgoing (148)

Target	Relation	Type	Str
Multisystem Proteinopathy	causes	disease	0.90
RNA Stress Granule	involved_in	process	0.90
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
ALS	activates	disease	0.75
motor neurons	activates	cell_type	0.70
stress granules	regulates	process	0.70
HSP70	inhibits	protein	0.70
ALS	associated_with	disease	0.70
amyotrophic lateral sclerosis	associated_with	disease	0.70
autophagy pathway	participates_in	pathway	0.70
Ms	activates	disease	0.65
Dementia	associated_with	disease	0.65
Cancer	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	activates	disease	0.65
ALS	interacts_with	disease	0.65
Neuroinflammation	treats	disease	0.65
Inflammation	treats	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cancer	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Tauopathy	inhibits	disease	0.65
Als	inhibits	disease	0.65
neurodegeneration	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
TAUOPATHY	inhibits	gene	0.60
Rna Splicing	inhibits	pathway	0.60
GABA	associated_with	gene	0.60
ATG	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
MATR3	associated_with	gene	0.60
HNRNPA1	degrades	gene	0.60
JUN	activates	gene	0.60
RANKL	activates	gene	0.60
GABARAP	associated_with	gene	0.60
TPRKB	activates	gene	0.60

Incoming (108)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.70
HNRNPA1	degrades	gene	0.60
VALOSIN	associated_with	gene	0.60
OPTN	degrades	gene	0.60
OPTINEURIN	degrades	gene	0.60
SQSTM1	degrades	gene	0.60
TAU	interacts_with	gene	0.60
TAU	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
ATF4	activates	entity	0.60
EIF2A	activates	entity	0.60
FMR1	activates	entity	0.60
G3BP1	activates	entity	0.60
GABARAP	activates	entity	0.60
MTOR	activates	entity	0.60
HNRNPA1	causes	entity	0.60
HNRNPA2B1	causes	entity	0.60
SQSTM1	causes	entity	0.60
FUNDC1	activates	gene	0.60
ATXN2	associated_with	gene	0.60
CNTN4	expressed_in	gene	0.60
PLIN4	expressed_in	gene	0.60
BID	expressed_in	gene	0.60
TDP-43	associated_with	gene	0.60
TBC1D24	expressed_in	gene	0.60
MAPT	associated_with	gene	0.60
CDKN1A	activates	gene	0.60
FUS	interacts_with	protein	0.60
NEURODEGENERATION	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
MATR3	degrades	gene	0.60
MITOPHAGY	activates	gene	0.60
NEURON	associated_with	gene	0.60
RANKL	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
TNFRSF11A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
ALS	associated_with	gene	0.60
RANK	activates	gene	0.60
RANKL	activates	gene	0.60
EIF2A	associated_with	gene	0.60
RANK	associated_with	gene	0.60
DEMENTIA	activates	gene	0.60
ATG	activates	gene	0.60
RNA	activates	gene	0.60
SARS	activates	gene	0.60
rapamycin	targets	drug	0.60
HNRNPA2B1	associated_with	gene	0.60
RNA	associated_with	gene	0.60
MATR3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TIA1 in their description or question text

No additional research found