protein

CATALASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CATALASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

602Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive page on Catalase - structure, function, role in oxidative stress and neurodegenerative diseases, and therapeutic potential

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🔬 Protein Info

Gene Symbol	CATALASE
Aliases	Comprehensive page on Catalase
Chromosome	11q13.1.
Primary Expression	Cortex, Hippocampus
Subcellular Localization	to peroxisomes in astrocytes and neurons, where it serves as a critical componen
Molecular Weight	60 kDa
Pathways	Autophagy, Mitophagy, Cell Cycle, Mapk, Apoptosis
GeneCards	CATALASE
Human Protein Atlas	CATALASE
Associated Diseases	cancer, oxidative stress
Known Drugs/Compounds	NICOTINAMIDE
Interactions	ABCD3, ACHE, Actin, AGING, AKT, ALS
KG Connections	596 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Catalase Protein

redirect · 645 words

→

Pathway Diagram

graph TD
    CATALASE["CATALASE"]
    CATALASE -->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
    CATALASE -->|"treats"| Parkinson_s_disease["Parkinson's disease"]
    CATALASE -->|"expressed in"| Neuronal_cells["Neuronal cells"]
    CATALASE -->|"activates"| AKT["AKT"]
    CATALASE -->|"activates"| GBM["GBM"]
    CATALASE -->|"activates"| HIF_1_["HIF-1Alpha"]
    CATALASE -->|"activates"| PI3K["PI3K"]
    NRF2["NRF2"] -->|"regulates"| CATALASE
    Exosomes["Exosomes"] -->|"interacts"| CATALASE
    ALS["ALS"] -->|"activates"| CATALASE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CATALASE
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| CATALASE
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CATALASE
    BECN1["BECN1"] -->|"activates"| CATALASE
    AMPK["AMPK"] -->|"activates"| CATALASE

Outgoing (393)

Target	Relation	Type	Str
Oxidative Stress	inhibits	process	0.70
Parkinson's disease	treats	disease	0.70
Parkinson's disease	treats	disease	0.70
Neuronal cells	expressed_in	cell_type	0.70
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Pyroptosis	activates	disease	0.65
Aging	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Aging	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Ferroptosis	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Als	biomarker_for	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Tumor	degrades	disease	0.65
Inflammation	activates	disease	0.65
ALS	biomarker_for	disease	0.65
Parkinson	activates	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
Aging	interacts_with	disease	0.65
NRF2	regulates	gene	0.60
Fus	interacts_with	protein	0.60
Erk	interacts_with	protein	0.60
Actin	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
GSH	associated_with	gene	0.60
Apoptosis	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
BCL-2	interacts_with	gene	0.60
BAX	interacts_with	gene	0.60
BAK	interacts_with	gene	0.60
Oxidative Stress	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
GSH	stabilizes	gene	0.60

Incoming (209)

Source	Relation	Type	Str
NRF2	upregulates	protein	0.90
PDGF-BB	upregulates	growth_factor	0.80
NRF2	regulates	protein	0.72
Exosomes	interacts_with	cell_type	0.70
GSH	associated_with	gene	0.60
NRF1	activates	gene	0.60
ROS	expressed_in	gene	0.60
GENES	activates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PARKINSON	activates	gene	0.60
TNF	expressed_in	gene	0.60
HSF1	activates	gene	0.60
IL-6	expressed_in	gene	0.60
ROS	regulates	gene	0.60
IL10	expressed_in	gene	0.60
RANK	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
GSH	stabilizes	gene	0.60
ACHE	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
BDNF	activates	gene	0.60
CREB	activates	gene	0.60
APP	activates	gene	0.60
C-JUN	activates	gene	0.60
DEMENTIA	activates	gene	0.60
EXERCISE	activates	gene	0.60
CAT	expressed_in	gene	0.60
GBM	activates	gene	0.60
AKT	activates	gene	0.60
DNA	interacts_with	gene	0.60
GSH	inhibits	gene	0.60
CAT	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
ERK	activates	gene	0.60
IL-18	activates	gene	0.60
IL-1	activates	gene	0.60
NLRP3	activates	gene	0.60
GSH	activates	gene	0.60
NRF2	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
IL-10	degrades	gene	0.60
BNIP3	interacts_with	gene	0.60
JNK	activates	gene	0.60
AGING	inhibits	gene	0.60
G3BP1	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CATALASE in their description or question text

No additional research found