gene

MAP1LC3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1973Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Microtubule-Associated Protein 1 Light Chain 3 Beta in autophagy and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	MAP1LC3B
Full Name	Microtubule-Associated Protein 1 Light Chain 3 Beta (LC3B)
Aliases	LC3B
Chromosome	16q24.2
Function	MAP1LC3B encodes LC3B, a key protein in the autophagy pathway.
Primary Expression	Ubiquitous, high in brain (neurons and glia), liver, heart, skeletal muscle
Molecular Weight	14.5 kDa
Amino Acids	125 aa
Pathways	Apoptosis, Autophagy, Immune Response, Innate Immunity, Mapk
UniProt ID	Q9GZQ8
NCBI Gene ID	81631
Ensembl ID	ENSG00000140941
OMIM	609605
GeneCards	MAP1LC3B
Human Protein Atlas	MAP1LC3B
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	cocaine, LPS, rapamycin
Interactions	ABCD3, ACTB, AGING, AIF1, AIFM1, ALOX
KG Connections	1972 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAP1LC3B — AlphaFold Q9GZQ8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP1LC3B["MAP1LC3B"] -->|"encodes"| LC3B["LC3B"]
    MAP1LC3B["MAP1LC3B"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| Ischemia["Ischemia"]
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| Ms["Ms"]
    MAP1LC3B["MAP1LC3B"] -->|"interacts"| Dementia["Dementia"]
    MAP1LC3B["MAP1LC3B"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    ACTB["ACTB"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    PPARA["PPARA"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    CAT["CAT"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    SQSTM1["SQSTM1"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    style MAP1LC3B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1123)

Target	Relation	Type	Str
Autophagy	activates	pathway	1.00
Als	activates	disease	1.00
Autophagy	associated_with	pathway	1.00
Aβ Clearance	involved_in	process	0.94
Aβ Aggregates	suppresses	process	0.92
cognitive function	protects_against	phenotype	0.90
amyloid beta	inhibits	protein	0.90
oxidative stress response	participates_in	pathway	0.90
ALZHEIMER'S DISEASE	involved_in	disease	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
Autophagy	regulates	pathway	0.90
autophagy	regulates	process	0.90
Autophagy	biomarker_for	process	0.85
Autophagy	component_of	process	0.85
Als	regulates	disease	0.85
CD274	binds	protein	0.85
Inflammation	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Parkinson's disease	regulates	disease	0.80
autophagy	part_of	pathway	0.80
CD274	interacts_with	protein	0.80
MEN1	regulates	gene	0.80
baicalein	enhances	drug	0.80
Parkinson's disease	activates	disease	0.80
apoptosis pathway	participates_in	pathway	0.80
Mitophagy	associated_with	process	0.80
PRKN	regulates	gene	0.80
OPTN	regulates	gene	0.80
RNA	activates	gene	0.80
SQSTM1	participates_in	gene	0.80
BAG3	participates_in	gene	0.80
HSPD1	biomarker_for	gene	0.80
HSPB8	participates_in	gene	0.80
BECN1	participates_in	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
Mtor	associated_with	pathway	0.80
AUTOPHAGY	activates	gene	0.80
MTOR	associated_with	gene	0.80
MITOCHONDRIA	activates	gene	0.80
RAS	activates	gene	0.75
Cancer	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Parkinson	regulates	disease	0.75
Cancer	associated_with	disease	0.75
Inflammation	inhibits	disease	0.75
Als	inhibits	disease	0.75
Inflammation	regulates	disease	0.75
Aging	associated_with	disease	0.75

Incoming (850)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	1.00
Menin	regulates	protein	0.97
rapamycin	targets	drug	0.90
Autophagy	upregulates	process	0.90
CD274	interacts_with	protein	0.90
amyloid beta	contributes_to	protein	0.90
CD274/PD-L1	interacts_with	protein	0.90
Tspan1	binds	protein	0.90
Dopamine-Conjugated Extracellular Vesicles	upregulates	compound	0.90
LC3	associated_with	gene	0.90
ROS	associated_with	gene	0.90
TFEB	upregulates	protein	0.85
CKLF	upregulates	protein	0.80
AR	activates	gene	0.80
SQSTM1	participates_in	gene	0.80
LAMP2	regulates	gene	0.80
DNA	activates	gene	0.80
CKLF1	contributes_to	gene	0.80
CKLF	contributes_to	protein	0.80
autophagy	regulates	pathway	0.80
AUTOPHAGY	regulates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
BECN1	associated_with	gene	0.80
P62	associated_with	gene	0.80
LC3B	activates	gene	0.80
SQSTM1	activates	gene	0.80
LC3B	interacts_with	gene	0.80
P62	activates	gene	0.80
TLR4	inhibits	protein	0.80
ATG	associated_with	gene	0.80
ATG5	associated_with	gene	0.75
BECN1	regulates	gene	0.70
LAMP1	associated_with	gene	0.70
DNM1L	regulates	gene	0.70
INFLAMMATION	regulates	gene	0.70
CANCER	associated_with	gene	0.70
LC3	activates	gene	0.70
ATG7	activates	gene	0.70
AMBRA1	regulates	gene	0.70
BECN1	activates	gene	0.70
CTSB	interacts_with	gene	0.70
LC3B	associated_with	gene	0.70
AMYLOID	associated_with	gene	0.70
HDAC6	regulates	gene	0.70
PARKINSON	regulates	gene	0.70
AMPK	regulates	gene	0.70
NEURODEGENERATIVE DISEASES	regulates	gene	0.70
ATP	activates	gene	0.70
PPARA	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAP1LC3B in their description or question text

No additional research found