concept

PGAM5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGAM5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

444Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PGAM5 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with AD, ALI, ALS. Connected to 187 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PGAM5
Key Genes/Proteins	ABCD3, Actin, AIFM1, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
Related Diseases	AD, ALI, Als, ALS, Alzheimer

Pathway Diagram

graph TD
    PGAM5["PGAM5"]
    PGAM5 -->|"regulates"| DRP1["DRP1"]
    PGAM5 -->|"interacts"| Alzheimer["Alzheimer"]
    PGAM5 -->|"interacts"| ALS["ALS"]
    PGAM5 -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    PGAM5 -->|"interacts"| Dementia["Dementia"]
    PGAM5 -->|"interacts"| Cardiovascular["Cardiovascular"]
    PGAM5 -->|"interacts"| Parkinson["Parkinson"]
    PGAM5 -->|"regulates"| Senescence["Senescence"]
    PGAM5 -->|"activates"| mitochondrial_fission["mitochondrial_fission"]
    PGAM5 -->|"inhibits"| cellular_senescence["cellular_senescence"]
    BCL2L11["BCL2L11"] -->|"interacts"| PGAM5
    DNA["DNA"] -->|"interacts"| PGAM5
    NIX["NIX"] -->|"interacts"| PGAM5
    HIF1["HIF1"] -->|"interacts"| PGAM5
    RB1["RB1"] -->|"interacts"| PGAM5
    NLRP3["NLRP3"] -->|"interacts"| PGAM5
    PARKINSON["PARKINSON"] -->|"interacts"| PGAM5
    FMR1["FMR1"] -->|"interacts"| PGAM5
    RB1CC1["RB1CC1"] -->|"interacts"| PGAM5
    PARL["PARL"] -->|"interacts"| PGAM5

Outgoing (224)

Target	Relation	Type	Str
Mitochondrial Dna Leakage	contributes_to	process	0.95
Mitochondrial Permeability Transition Pore	promotes	mechanism	0.95
Mitochondrial Dynamics	regulates	process	0.95
Cgas-Sting Pathway	activates	pathway	0.95
DRP1	promotes	protein	0.95
Cellular Senescence	modulates	process	0.95
Ubiquitin-Proteasome Degradation	suppresses	process	0.90
Mitochondrial Fission	activates	process	0.90
Neuronal Apoptosis	promotes	process	0.90
PINK1	associated_with	protein	0.85
Neurotoxic Astrocyte Reactivity	correlates_with	phenotype	0.85
Intracerebral Hemorrhage	implicated_in	disease	0.85
DRP1	regulates	protein	0.72
Cancer	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Cardiac	regulates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Senescence	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	activates	disease	0.65
Myocardial Infarction	implicated_in	disease	0.65
cellular_senescence	inhibits	phenotype	0.64
mitochondrial_fission	activates	phenotype	0.64
ALZHEIMER DISEASE	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60

Incoming (220)

Source	Relation	Type	Str
USP11	associated_with	gene	0.95
MITOCHONDRIA	regulates	gene	0.70
NIX	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
PTEN	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ATP	causes	gene	0.60
DRP1	activates	gene	0.60
ROS	causes	gene	0.60
MTOR	activates	gene	0.60
MITOPHAGY	causes	gene	0.60
IFN	causes	gene	0.60
FMR1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
MAPK8	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PGAM5 in their description or question text

No additional research found