gene

MUL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MUL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

589Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MUL1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 306 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MUL1
Full Name	Mitochondrial E3 Ubiquitin Protein Ligase 1
Chromosome	1p36.22
Protein Type	Ligase
Function	MUL1 encodes a mitochondrial outer membrane E3 ubiquitin protein ligase that plays crucial roles in mitochondrial dynamics, mitophagy, and apoptosis regulation.
Molecular Weight	37 kDa
Pathways	Akt, Apoptosis, Mitochondrial Function, Mitophagy, Nf-Κb
UniProt ID	[Q9H3K2](https://www.uniprot.org/uniprot/Q9H3K2)
Ensembl ID	ENSG00000067082
OMIM	612148
GeneCards	MUL1
Human Protein Atlas	MUL1
Mitophagy enhancers	Boosting MUL1 activity to improve mitochondrial quality control
Ubiquitin-proteasome modulators	Targeting MUL1-mediated degradation pathways
Mitochondrial protectants	Supporting mitochondrial function downstream of MUL1
Associated Diseases	AD, ALI, Als, Alzheimer, Cancer
Interactions	ABCD3, ACETYL-COA, Actin, ADRB2, AKT, ALS
KG Connections	589 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MUL1 Gene

gene · 556 words

→

MUL1 Protein

protein · 959 words

→

Pathway Diagram

flowchart TD
    MUL1["MUL1
E3 Ubiquitin Ligase"]
    
    DRP1["DRP1
Mitochondrial Fission"]
    BNIP3["BNIP3
Mitophagy Receptor"]
    BECN1["BECN1
Autophagy Initiation"]
    NBR1["NBR1
Autophagy Adapter"]
    
    CHOP["CHOP/DDIT3
ER Stress Response"]
    EIF2S1["EIF2S1
Translation Control"]
    RIPK3["RIPK3
Necroptosis"]
    MAPK8["MAPK8/JNK
Stress Signaling"]
    
    PTEN["PTEN
PI3K/AKT Inhibitor"]
    DISC1["DISC1
Neurodevelopment"]
    
    Mitophagy["Mitochondrial
Quality Control"]
    ER_Stress["ER Stress
Response"]
    Cell_Death["Neuronal
Cell Death"]
    
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    FTD["Frontotemporal
Dementia"]
    
    MUL1 -->|"regulates"| DRP1
    MUL1 -->|"activates"| BNIP3
    MUL1 -->|"promotes"| BECN1
    MUL1 -->|"interacts"| NBR1
    
    DRP1 -->|"promotes"| Mitophagy
    BNIP3 -->|"promotes"| Mitophagy
    BECN1 -->|"promotes"| Mitophagy
    NBR1 -->|"promotes"| Mitophagy
    
    MUL1 -->|"interacts"| CHOP
    MUL1 -->|"regulates"| EIF2S1
    CHOP -->|"promotes"| ER_Stress
    EIF2S1 -->|"regulates"| ER_Stress
    
    MUL1 -->|"inhibits"| RIPK3
    MUL1 -->|"modulates"| MAPK8
    RIPK3 -->|"promotes"| Cell_Death
    MAPK8 -->|"promotes"| Cell_Death
    
    MUL1 -->|"interacts"| PTEN
    MUL1 -->|"interacts"| DISC1
    
    ER_Stress -->|"contributes"| Cell_Death
    Cell_Death -->|"leads_to"| Alzheimer
    Cell_Death -->|"leads_to"| Parkinson
    Cell_Death -->|"leads_to"| ALS
    Cell_Death -->|"leads_to"| FTD
    
    style MUL1 fill:#006494
    style Mitophagy fill:#1b5e20
    style BECN1 fill:#1b5e20
    style BNIP3 fill:#1b5e20
    style NBR1 fill:#1b5e20
    style PTEN fill:#4a1a6b
    style DISC1 fill:#4a1a6b
    style CHOP fill:#ef5350
    style RIPK3 fill:#ef5350
    style ER_Stress fill:#ef5350
    style Cell_Death fill:#ef5350
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style ALS fill:#5d4400
    style FTD fill:#5d4400

Outgoing (295)

Target	Relation	Type	Str
Cancer	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Cardiac	activates	disease	0.65
Ms	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Als	inhibits	disease	0.65
Cardiovascular	regulates	disease	0.65
Inflammation	contributes_to	disease	0.65
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Tumor	regulates	disease	0.65
Tumor	inhibits	disease	0.65
Als	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Aging	activates	disease	0.65
Inflammation	regulates	disease	0.65
Obesity	activates	disease	0.65
Ms	inhibits	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
ALS	interacts_with	disease	0.65
ABCD3	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
TBK1	associated_with	gene	0.60
Cholesterol	inhibits	pathway	0.60
Complement	inhibits	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Immune Response	activates	pathway	0.60
Akt	regulates	pathway	0.60
Apoptosis	contributes_to	pathway	0.60
Mitophagy	contributes_to	pathway	0.60
Immune Response	contributes_to	pathway	0.60

Incoming (294)

Source	Relation	Type	Str
USP30	regulates	gene	0.60
CPT2	activates	gene	0.60
PARKIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
PINK1	therapeutic_target	gene	0.60
UBIQUITIN	activates	gene	0.60
LC3B	activates	gene	0.60
G6PD	activates	gene	0.60
GSH	activates	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
DDIT3	activates	entity	0.60
DISC1	activates	entity	0.60
DNM1L	activates	entity	0.60
VHL	regulates	gene	0.60
MAVS	inhibits	gene	0.60
UBIQUITIN	associated_with	gene	0.60
HERC5	activates	gene	0.60
MAVS	activates	gene	0.60
PPP1R15B	interacts_with	gene	0.60
ADRB2	inhibits	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
AKT	regulates	gene	0.60
SLC44A2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MUL1 in their description or question text

No additional research found