gene

PEX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PEX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

466Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for PEX3 Gene - Peroxisome Biogenesis Factor 3

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🧬 Gene Info

Gene Symbol	PEX3
Full Name	Peroxisome Biogenesis Factor 3
Aliases	Page for PEX3 Gene, Page for PEX3 Protein
Function	is a 476-amino acid peroxisomal membrane protein that plays a central role in peroxisome biogenesis.
Molecular Weight	52 kDa
Amino Acids	476 aa
Pathways	MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway, autophagy pathway
Ensembl ID	ENSG00000034693
GeneCards	PEX3
Human Protein Atlas	PEX3
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	466 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PEX3 Gene - Peroxisome Biogenesis Factor 3

gene · 1225 words

→

PEX3 Protein - Peroxisome Biogenesis Factor 3

protein · 719 words

→

Pathway Diagram

flowchart TD
    PEX3["PEX3
Peroxisome Biogenesis
Factor 3"]
    
    SQSTM1["SQSTM1/p62
Autophagy Receptor"]
    LC3["LC3
Autophagy Marker"]
    RB1CC1["RB1CC1/FIP200
Autophagy Initiation"]
    
    PARKIN["PARKIN
E3 Ubiquitin Ligase"]
    SNCA["SNCA
alpha-Synuclein"]
    SNCAIP["SNCAIP
Synphilin-1"]
    
    MFN1["MFN1
Mitofusin 1
Mitochondrial Fusion"]
    BCL2["BCL2
Anti-apoptotic
Protein"]
    
    ERN1["ERN1/IRE1alpha
ER Stress
Sensor"]
    FAM134B["FAM134B
ER-phagy
Receptor"]
    
    ATM["ATM
DNA Damage
Response"]
    STING1["STING1
Innate Immunity
Signaling"]
    
    PD["Parkinson's
Disease"]
    AD["Alzheimer's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    FTD["Frontotemporal
Dementia"]
    
    PEX3 -->|"regulates"| SQSTM1
    SQSTM1 -->|"binds"| LC3
    PEX3 -->|"interacts"| RB1CC1
    
    PEX3 -->|"interacts"| PARKIN
    PARKIN -->|"ubiquitinates"| SNCA
    PEX3 -->|"interacts"| SNCAIP
    SNCA -->|"aggregates"| PD
    
    PEX3 -->|"regulates"| MFN1
    PEX3 -->|"interacts"| BCL2
    MFN1 -->|"maintains"| BCL2
    
    PEX3 -->|"responds_to"| ERN1
    PEX3 -->|"interacts"| FAM134B
    ERN1 -->|"activates"| FAM134B
    
    PEX3 -->|"interacts"| ATM
    PEX3 -->|"modulates"| STING1
    ATM -->|"triggers"| STING1
    
    SQSTM1 -->|"dysfunction"| AD
    PARKIN -->|"mutations"| PD
    ERN1 -->|"stress_response"| ALS
    ATM -->|"damage_response"| FTD
    
    style PEX3 fill:#006494
    style SQSTM1 fill:#4a1a6b
    style LC3 fill:#4a1a6b
    style PARKIN fill:#4a1a6b
    style BCL2 fill:#1b5e20
    style MFN1 fill:#1b5e20
    style ERN1 fill:#ef5350
    style ATM 填:#ef5350
    style PD fill:#5d4400
    style AD fill:#5d4400
    style ALS fill:#5d4400
    style FTD fill:#5d4400

Outgoing (225)

Target	Relation	Type	Str
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
RAS	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
Endothelial	interacts_with	cell_type	0.60
PARKINSON	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60

Incoming (241)

Source	Relation	Type	Str
PPAR	activates	gene	0.60
PEX5	activates	gene	0.60
PEX19	interacts_with	gene	0.60
PEX19	expressed_in	gene	0.60
PPP1R7	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PEX3 in their description or question text

No additional research found