concept

ENDOTHELIAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOTHELIAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2037Connections

4Hypotheses

0Analyses

50Outgoing

50Incoming

10Experiments

0Debates

Summary

ENDOTHELIAL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, causes. Associated with ALS, ALZHEIMER, ATHEROSCLEROSIS. Connected to 168 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ENDOTHELIAL
Key Genes/Proteins	AB, ABCA1, ABCD3, ACHE, AD, adamts4
Related Diseases	aging, ALS, ALZHEIMER, Alzheimer Disease

Pathway Diagram

graph TD
    ENDOTHELIAL["ENDOTHELIAL"]
    ENDOTHELIAL -->|"causes"| INFLAMMATION["INFLAMMATION"]
    ENDOTHELIAL -->|"contributes to"| IMMUNE_RESPONSE["IMMUNE RESPONSE"]
    ENDOTHELIAL -->|"degrades"| FRONTOTEMPORAL["FRONTOTEMPORAL"]
    ENDOTHELIAL -->|"degrades"| FTD["FTD"]
    ENDOTHELIAL -->|"degrades"| GBA["GBA"]
    ENDOTHELIAL -->|"causes"| HIF1A["HIF1A"]
    ENDOTHELIAL -->|"activates"| JNK["JNK"]
    ENDOTHELIAL -->|"interacts"| LC3["LC3"]
    ENDOTHELIAL -->|"activates"| MAPK["MAPK"]
    ENDOTHELIAL -->|"activates"| NLRP3["NLRP3"]
    ENDOTHELIAL -->|"activates"| OPTN["OPTN"]
    ENDOTHELIAL -->|"activates"| P62["P62"]
    CD2AP["CD2AP"] -->|"causes"| ENDOTHELIAL
    ALS["ALS"] -->|"activates"| ENDOTHELIAL
    ALZHEIMER["ALZHEIMER"] -->|"activates"| ENDOTHELIAL
    AMPK["AMPK"] -->|"activates"| ENDOTHELIAL
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ENDOTHELIAL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ENDOTHELIAL
    BCL2["BCL2"] -->|"regulates"| ENDOTHELIAL
    BECN1["BECN1"] -->|"interacts"| ENDOTHELIAL
    CAT["CAT"] -->|"causes"| ENDOTHELIAL
    DEMENTIA["DEMENTIA"] -->|"degrades"| ENDOTHELIAL

Outgoing (588)

Target	Relation	Type	Str
ds-f2c28aed24a7	provides_data_for	dataset	1.00
PERICYTE	targets	cell_type	0.70
NOTCH	disrupts	gene	0.70
VEGF	expresses	gene	0.70
PERICYTE	interacts_with	cell_type	0.70
STING	inhibits	gene	0.70
NRF2	inhibits	gene	0.70
NRF2	activates	gene	0.70
RAGE	causes	gene	0.70
TAU	expresses	gene	0.70
GASDERMIN	inhibits	gene	0.70
NEURONS	disrupts	cell_type	0.70
STAT3	regulates	gene	0.70
XIAP	inhibits	gene	0.70
MMP2	activates	gene	0.70
PERICYTES	expresses	cell_type	0.70
MACROPHAGE	activates	cell_type	0.70
SHH	activates	gene	0.70
OCLN	expresses	gene	0.70
VEGF	activates	gene	0.70
LRP1	causes	gene	0.70
RAGE	activates	gene	0.70
LRP1	expresses	gene	0.70
NOTCH	expresses	gene	0.70
NLRP3	inhibits	gene	0.70
HUNTINGTON'S DISEASE	activates	disease	0.70
LRP1	interacts_with	gene	0.70
IGF1	activates	gene	0.70
MMP2	associated_with	gene	0.70
SOD1	activates	gene	0.70
SMPD1	regulates	gene	0.70
STAT3	interacts_with	gene	0.70
TAU	causes	gene	0.70
PERICYTE	expresses	cell_type	0.70
LRP1	associated_with	gene	0.70
LRP1	activates	gene	0.70
GPX4	activates	gene	0.70
MULTIPLE SCLEROSIS	enhances	disease	0.70
OLIGODENDROCYTE	inhibits	cell_type	0.70
NEURONS	protects_against	cell_type	0.70
TAU	activates	gene	0.70
P2RX7	activates	gene	0.70
INSULIN SIGNALING	activates	pathway	0.70
TNF	associated_with	gene	0.70
PERICYTE	activates	cell_type	0.70
GASDERMIN	activates	gene	0.70
PARP1	activates	gene	0.70
RAGE	interacts_with	gene	0.70
RAGE	expresses	gene	0.70
PERICYTES	targets	cell_type	0.70

Incoming (1449)

Source	Relation	Type	Str
ds-f2c28aed24a7	data_in	dataset	1.00
CX3CL1	activates	gene	0.70
ACHE	activates	gene	0.70
ASTROCYTE	targets	cell_type	0.70
APP	interacts_with	gene	0.70
CCL2	interacts_with	gene	0.70
CREB	regulates	gene	0.70
DBH	activates	gene	0.70
APP	causes	gene	0.70
CXCL10	inhibits	gene	0.70
CDK5	activates	gene	0.70
APOE	regulates	gene	0.70
BACE1	inhibits	gene	0.70
ATG7	interacts_with	gene	0.70
BECN1	regulates	gene	0.70
BMP	activates	gene	0.70
APOE	transports	gene	0.70
CLDN5	protects_against	gene	0.70
BACE1	protects_against	gene	0.70
APOE	expresses	gene	0.70
ASTROCYTE	disrupts	cell_type	0.70
ASTROCYTE	protects_against	cell_type	0.70
ASTROCYTE	expressed_in	cell_type	0.70
AMPK	protects_against	gene	0.70
CD2AP	expressed_in	gene	0.70
BECN1	associated_with	gene	0.70
ASTROCYTE	regulates	cell_type	0.70
BACE1	associated_with	gene	0.70
ABCA1	interacts_with	gene	0.70
CX3CL1	targets	gene	0.70
CX3CR1	targets	gene	0.70
ALZHEIMER'S DISEASE	contributes_to	disease	0.65
ATHEROSCLEROSIS	causes	disease	0.65
CANCER	regulates	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
ASTROCYTES	expressed_in	cell_type	0.65
ATHEROSCLEROSIS	processes	disease	0.65
ALZHEIMER	associated_with	disease	0.65
ASTROCYTES	enhances	cell_type	0.60
ASTROCYTE	enhances	cell_type	0.60
TNF	associated_with	gene	0.60
PEX3	interacts_with	gene	0.60
MIRNAS	associated_with	gene	0.60
AKT	causes	gene	0.60
BCL2	regulates	gene	0.60
AMPK	activates	gene	0.60
ALZHEIMER	activates	disease	0.60
DIABETES	associated_with	disease	0.60
AKT	targets	gene	0.60
PARL	interacts_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Synthetic Biology BBB Endothelial Cell Reprogramming	0.727	neurodegeneration	Blood-brain barrier transport mechanisms
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat	0.705	neurodegeneration	Perivascular spaces and glymphatic clear
Endothelial NRF2 Activation as a Master Switch for Post-CA B	0.689	neurodegeneration	View

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and dow [PMID:38677244]	Fei Y, Huang X, Ning F, Qian T, Cui J, W	Biomed Pharmacother	2024	1
Protectin conjugates in tissue regeneration 1 restores lipopolysaccharide-induce [PMID:34217286]	Wang XY, Li XY, Wu CH, Hao Y, Fu PH, Mei	Respir Res	2021	1
The glycocalyx: a novel diagnostic and therapeutic target in sepsis. [PMID:30654825]	Uchimido R, Schmidt EP, Shapiro NI	Crit Care	2019	1
Pathogenic Significance of Serum Syndecan-1 and Syndecan-4 in Psoriasis. [PMID:41839009]	Yıldırım MA, Korkmaz S, Çelik HHA, Büyük	Cutis	2026	0
CD138 expression in the endometrium associates with endometrial timing and infla [PMID:41858134]	Odendaal J, Fishwick K, Correia GDS, Lee	Human reproduction (Oxford, En	2026	0
[Multicenter prospective study on the diagnostic value of syndecan-1 for necroti [PMID:41914411]	Yin XY, Zhao ZH, Wang Y, Cai N, Chen S	Zhongguo dang dai er ke za zhi	2026	0
Association of Viraemic Phase Viral Load, Antibody Responses, and Immune Biomark [PMID:41891425]	Alagarasu K, Gurav YK, Pulinchani A, Bac	Journal of medical virology	2026	0
Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Tra [PMID:41847595]	Mathis S, Putzer G, Gasteiger L, Staier	Transplant international : off	2026	0
Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic bas [PMID:36577758]	Gharbi Severine Isabelle; Pelletier Laur	NPJ breast cancer	2022	0
The biology of beauty sleep. [PMID:35256810]	Jordan A Anderson; Jenny Tung	Nature ecology & evolution	2022	0
Cathepsin S is a novel target for age-related dry eye. [PMID:34910926]	["Yu Z", "Li J", "Govindarajan G", "Hamm	Experimental eye research	2022	0
Ageing alters the lipid sensing process in the hypothalamus of Wistar rats. Effe [PMID:33544062]	["Rodr\u00edguez M", "Pintado C", "Torri	Nutritional neuroscience	2022	0
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound [PMID:33947867]	["Yu K", "Niu X", "Krook-Magnuson E", "H	Nature communications	2021	0
Warning wristbands for patients with intra-ocular gas [PMID:31745326]	Naderi Khayam; Masoero Pietro; Karthikey	Eye	2020	0
NK cells for cancer immunotherapy. [PMID:31907401]	["Shimasaki N", "Jain A", "Campana D"]	Nature reviews. Drug discovery	2020	0
Potent and specific MTH1 inhibitors targeting gastric cancer. [PMID:31164636]	["Zhou W", "Ma L", "Yang J", "Qiao H", "	Cell death & disease	2019	0
Clinical factors associated with worse quality-of-life scores in United States t [PMID:30898373]	["Goswami S", "Peipert B", "Mongelli M",	Surgery	2019	0
Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through [PMID:31393853]	["Parimon T", "Yao C", "Habiel D", "Ge L	JCI insight	2019	0
Arabidopsis Duodecuple Mutant of PYL ABA Receptors Reveals PYL Repression of ABA [PMID:29898403]	["Zhao Y", "Zhang Z", "Gao J", "Wang P",	Cell reports	2018	0
Cell transplantation therapy for spinal cord injury. [PMID:28440805]	["Assinck P", "Duncan G", "Hilton B", "P	Nature neuroscience	2017	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOTHELIAL in their description or question text

No additional research found