gene

CANX

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CANX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

549Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Calnexin is an ER membrane chaperone protein involved in protein folding, calcium homeostasis, and ER stress responses in neurodegeneration.

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🧬 Gene Info

Gene Symbol	CANX
Full Name	Calnexin
Protein Type	Chaperone
Function	is a calcium-binding chaperone protein located in the endoplasmic reticulum (ER) membrane that plays a critical role in protein folding, quality control, and calcium homeostasis.
Primary Expression	Hippocampus
Pathways	Apoptosis, Mitophagy, Autophagy, Mapk, Cell Cycle
GeneCards	CANX
Human Protein Atlas	CANX
ERp57	A thiol-disulfide oxidoreductase that works with calnexin to promote proper disulfide bond formation
ERp72	Another ER-resident chaperone involved in protein folding
Bip/GRP78	The major ER chaperone that binds to misfolded proteins
Calreticulin	The soluble counterpart of calnexin in the ER lumen
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	549 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CANX — Calnexin

gene · 1744 words

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Pathway Diagram

graph TD
    CANX["CANX"] -->|"Interacts With"| ULK1["ULK1"]
    CANX["CANX"] -->|"Regulates"| autophagy["autophagy"]
    CANX["CANX"] -->|"Modulates"| cognitive_function["cognitive function"]
    CANX["CANX"] -->|"Expressed In"| hippocampal_neurons["hippocampal neurons"]
    CANX["CANX"] -->|"Interacts With"| Dementia["Dementia"]
    CANX["CANX"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    CANX["CANX"] -->|"Interacts With"| Als["Als"]
    CANX["CANX"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    WLS["WLS"] -->|"Interacts With"| CANX["CANX"]
    CAT["CAT"] -->|"Interacts With"| CANX["CANX"]
    OPTN["OPTN"] -->|"Interacts With"| CANX["CANX"]
    DNM1L["DNM1L"] -->|"Interacts With"| CANX["CANX"]
    MFN1["MFN1"] -->|"Interacts With"| CANX["CANX"]
    style CANX fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#0d47a1,color:#e0e0e0
    style autophagy fill:#1b5e20,color:#e0e0e0
    style cognitive_function fill:#1b5e20,color:#e0e0e0
    style hippocampal_neurons fill:#795548,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style WLS fill:#0d47a1,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style MFN1 fill:#8d4900,color:#e0e0e0

Outgoing (361)

Target	Relation	Type	Str
autophagy pathway	participates_in	pathway	0.70
Alzheimer's disease	protects_against	disease	0.70
ULK1	interacts_with	protein	0.70
autophagy	regulates	process	0.70
hippocampal neurons	expressed_in	cell_type	0.70
cognitive function	regulates	process	0.70
Ftd	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Necroptosis	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	expressed_in	disease	0.65
Necroptosis	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	expressed_in	disease	0.65
GLIOBLASTOMA	expressed_in	gene	0.60
Fus	interacts_with	protein	0.60
NLR	interacts_with	gene	0.60
Pi3K	expressed_in	protein	0.60
Raf	regulates	protein	0.60
CATALASE	regulates	gene	0.60
dementia	associated_with	disease	0.60
Akt	expressed_in	protein	0.60
Mtor	expressed_in	pathway	0.60
Neuron	regulates	cell_type	0.60
JNK	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
Macrophage	expressed_in	cell_type	0.60
Actin	expressed_in	protein	0.60
IL-1B	inhibits	gene	0.60
DRP1	activates	entity	0.60
Immune Response	inhibits	pathway	0.60
MAPK	expressed_in	gene	0.60
Raf	activates	protein	0.60
Il-1	inhibits	protein	0.60
endothelial cells	expressed_in	cell_type	0.60
DNM1L	interacts_with	gene	0.60
Parkinson	associated_with	disease	0.60
Pi3K/Akt	expressed_in	pathway	0.60

Incoming (188)

Source	Relation	Type	Str
WLS	interacts_with	protein	0.70
MAPK8	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
EMD	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
CHOP	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
RAB7A	therapeutic_target	gene	0.60
IGF2R	therapeutic_target	gene	0.60
CAPZB	therapeutic_target	gene	0.60
RAB5A	therapeutic_target	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
RAB8A	therapeutic_target	gene	0.60
KAT7	regulates	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
PHB2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
ATP	activates	gene	0.60
PRESENILIN	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
PGAM5	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
ALZHEIMER DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURON	activates	gene	0.60
AMPK	interacts_with	gene	0.60
HIF1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
CATALASE	interacts_with	gene	0.60
AMPK	activates	entity	0.60
ALS	activates	entity	0.60
AND	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CANX in their description or question text

No additional research found