gene

ABCA7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

594Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	ABCA7
Chromosome	19q13
Function	ABCA7 encodes ATP-binding cassette transporter A7, a member of the ABC transporter family.
Primary Expression	immune cells and the brain, where it plays important roles in lipid transport and cellular homeostasis
Subcellular Localization	and processing of APP, potentially increasing amyloidogenic cleavage pathways
Pathways	Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Nf-Κb
Ensembl ID	ENSG00000064687
GeneCards	ABCA7
Human Protein Atlas	ABCA7
Associated Diseases	age-related macular degeneration, Als, Alzheimer, Alzheimer's disease
Interactions	ABCA1, ABCA4, ABCG1, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	594 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ABCA7["ABCA7"] -->|"modulates"| Cholesterol_Transport["Cholesterol Transport"]
    ABCA7["ABCA7"] -->|"associated"| APOE["APOE"]
    ABCA7["ABCA7"] -->|"associated"| Alzheimer["Alzheimer"]
    ABCA7["ABCA7"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ABCA7["ABCA7"] -->|"associated"| TREM2["TREM2"]
    ABCA7["ABCA7"] -->|"associated"| ALZHEIMER["ALZHEIMER"]
    ABCA1["ABCA1"] -->|"associated"| ABCA7["ABCA7"]
    PLCG2["PLCG2"] -->|"associated"| ABCA7["ABCA7"]
    TREM2_1["TREM2"] -->|"regulates"| ABCA7["ABCA7"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"protects against"| ABCA7["ABCA7"]
    style ABCA7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (459)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA7	data_in	dataset_row	0.00
ad_genetic_risk_loci:ABCA7	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Macrophages	expressed_in	cell_type	0.95
Alzheimer's Disease	risk_factor_for	disease	0.95
Phagocytosis	regulates	process	0.90
Phospholipid Homeostasis	regulates	process	0.90
Microglial Aβ Clearance	involved_in	process	0.90
APP Processing	modulates	process	0.85
Phagocytosis	mediates	process	0.85
Neuropeptide Y	induces	protein	0.80
Amyloid-β	transports	compound	0.80
cholesterol transport	regulates	process	0.80
ATP	interacts_with	gene	0.80
BDNF	induces	protein	0.80
ApoE particles	interacts_with	protein	0.80
Oxidized Unsaturated Lipids	transports	compound	0.80
Lipid Processing	modulates	process	0.80
Cholesterol Transport	modulates	process	0.80
stem cells	expressed_in	cell_type	0.80
neurons	expressed_in	cell_type	0.80
Alzheimer	associated_with	disease	0.75
APOE	associated_with	gene	0.75
Alzheimer's disease	interacts_with	disease	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
ABCA1	interacts_with	protein	0.70
Alzheimer	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
Alzheimer	activates	disease	0.65
Alzheimer	regulates	disease	0.65
GLUTAMATE	exacerbates	phenotype	0.65
NEURON	produces	cell_type	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	associated_with	disease	0.65
SNCA	co_discussed	gene	0.65
Als	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
ALS	regulates	disease	0.65
SQSTM1	co_discussed	gene	0.65
TREM2	co_discussed	gene	0.65
PSEN2	co_discussed	gene	0.65
OPTN	co_discussed	gene	0.65
ATP13A2	co_discussed	gene	0.65
TREM2	associated_with	gene	0.65
Macular Degeneration	transports	disease	0.65

Incoming (135)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA7	data_in	dataset_row	0.00
ad_genetic_risk_loci:ABCA7	data_in	dataset_row	0.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
ds-f50762b67605	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-db4a006ea647	data_in	dataset	1.00
genes-abca7	describes	wiki_page	0.95
AMYLOID	associated_with	protein	0.82
APOE2	interacts_with	protein	0.80
APOE	associated_with	gene	0.74
TREM2	associated_with	gene	0.66
MICROGLIA	associated_with	cell_type	0.66
APP	exacerbates	gene	0.65
ABCA1	associated_with	gene	0.65
AMYLOID	treats	protein	0.65
APOE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
APP/PS1	regulates	gene	0.60
TREM2	regulates	gene	0.60
LPL	regulates	gene	0.60
AMPK	regulates	gene	0.60
HIF-1Α	regulates	gene	0.60
MS4A6A	interacts_with	gene	0.60
TYK2	regulates	gene	0.60
PILRA	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
MAF	associated_with	gene	0.60
PLD3	associated_with	gene	0.60
CR1	associated_with	gene	0.60
ZCWPW1	interacts_with	gene	0.60
GAB2	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
GENES	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
GENES	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
INOS	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ATP	transports	gene	0.60
ABCA4	transports	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ZCWPW1	activates	gene	0.60
FERMT2	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF Biomarker-Guided ABCA7 Therapeutic Dosing	0.619	neurodegeneration	Why does the V1613M variant reduce amylo
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.619

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mi

closed · Rounds: 4 · Score: 0.60 · 2026-04-15