Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PTEN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PTEN is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 1455 entities in the SciDEX knowledge graph.
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| Gene Symbol | PTEN |
| Chromosome | 10 |
| Function | is a critical tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway, playing essential roles in neuronal survival, synaptic plasticity, and cellular homeostasis[@pten2021]. |
| Molecular Weight | 47 kDa |
| Amino Acids | 403 aa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone |
| GeneCards | PTEN |
| Human Protein Atlas | PTEN |
| Phosphorylation | Ser380/Thr382/Thr383 phosphorylation inhibits PTEN activity and promotes stability |
| Oxidation | Reactive oxygen species can transiently inhibit PTEN |
| Ubiquitination | WWP2-mediated ubiquitination targets PTEN for degradation |
| Acetylation | p300/CBP-mediated acetylation reduces PTEN function |
| SUMOylation | Modulates PTEN localization and function |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | circRNA, dimethyl fumarate, metformin, quercetin, rapamycin, RAPAMYCIN |
| Interactions | ABCD3, ABP, ACETYL-COA, Actin, ACVR1, ADSL |
| KG Connections | 2527 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PTEN["PTEN"] -.->|"inhibits"| PI3K["PI3K"]
PTEN["PTEN"] -->|"interacts"| Dementia["Dementia"]
PTEN["PTEN"] -->|"interacts"| Cardiovascular["Cardiovascular"]
PTEN["PTEN"] -->|"interacts"| Als["Als"]
PTEN["PTEN"] -->|"interacts"| Alzheimer["Alzheimer"]
PTEN["PTEN"] -->|"interacts"| Parkinson["Parkinson"]
CAT["CAT"] -->|"interacts"| PTEN["PTEN"]
OPTN["OPTN"] -->|"interacts"| PTEN["PTEN"]
DNM1L["DNM1L"] -->|"interacts"| PTEN["PTEN"]
CANX["CANX"] -->|"interacts"| PTEN["PTEN"]
style PTEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | inhibits | disease | 1.00 |
| PI3K | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PI3K | inhibits | protein | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| MTOR | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| AKT | inhibits | protein | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| MTOR | activates | gene | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | activates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 0.98 |
| MITOPHAGY | activates | gene | 0.98 |
| PARKIN | activates | gene | 0.98 |
| FBXO32 | binds_to | protein | 0.95 |
| FBXO32 | cleaves | protein | 0.90 |
| TET1 | upregulates | gene | 0.85 |
| Theranekron | upregulates | drug | 0.85 |
| AKT | activates | gene | 0.82 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.82 |
| Structural Variations | associated_with | mechanism | 0.80 |
| oncogenic microRNAs | inhibits | protein | 0.80 |
| phosphorylation | inhibits | phenotype | 0.80 |
| oxidation | inhibits | phenotype | 0.80 |
| GABPB1 | upregulates | gene | 0.80 |
| ubiquitination | inhibits | phenotype | 0.80 |
| CHD7 | coexpressed_with | gene | 0.80 |
| MIRNAS | activates | gene | 0.80 |
| PI3K | activates | gene | 0.74 |
| MTOR | associated_with | gene | 0.74 |
| PI3K | associated_with | gene | 0.74 |
| MTOR | activates | gene | 0.74 |
| NF-KB | associated_with | protein | 0.74 |
| STAT3 | activates | gene | 0.70 |
| fumarate | regulates | process | 0.70 |
| MAP1LC3B | regulates | gene | 0.70 |
| NLR | regulates | gene | 0.70 |
| LC3B | regulates | gene | 0.70 |
| CANCER | associated_with | gene | 0.70 |
| MIRNAS | therapeutic_target | gene | 0.70 |
| PRKN | regulates | gene | 0.70 |
| NEURODEGENERATION | activates | gene | 0.70 |
| circRNA | modulates | drug | 0.70 |
| CANCER | inhibits | gene | 0.70 |
| CANCER | expressed_in | gene | 0.70 |
| INFLAMMATION | activates | gene | 0.70 |
| OPTN | regulates | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| Ubiquitination | regulates | mechanism | 0.70 |
| AGO2 | activates | gene | 0.70 |
| GSK3β | activates | protein | 0.70 |
| CANCER | therapeutic_target | gene | 0.70 |
| DNM1L | biomarker_for | gene | 0.70 |
| CALCOCO2 | regulates | gene | 0.70 |
| EGFR | interacts_with | entity | 0.70 |
| BECN1 | activates | gene | 0.66 |
| EGFR | associated_with | gene | 0.66 |
| PARKIN | associated_with | gene | 0.66 |
| LC3 | activates | gene | 0.66 |
| AKT | associated_with | gene | 0.66 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PTEN in their description or question text
No additional research found