concept

ATG8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

272Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG8 is a concept in neurodegeneration research. Key relationships include: interacts with, activates, implicated in. Associated with ALS, Aging, Als. Connected to 128 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ATG8
Key Genes/Proteins	Actin, AGING, AND, APOPTOSIS, App, ATF4
Related Diseases	Aging, Als, ALS, Ataxia
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    ATG8["ATG8"]
    ATG8 -->|"interacts"| PE["PE"]
    ATG8 -->|"interacts"| PS["PS"]
    ATG8 -->|"interacts"| Aging["Aging"]
    ATG8 -->|"interacts"| ALS["ALS"]
    ATG8 -->|"interacts"| Cancer["Cancer"]
    ATG8 -->|"activates"| Ms["Ms"]
    ATG8 -->|"activates"| Parkinson["Parkinson"]
    ATG8 -->|"inhibits"| Als["Als"]
    ATG8 -->|"interacts"| LGALS8["LGALS8"]
    ATG8 -->|"regulates"| MTOR["MTOR"]
    ATG8 -->|"interacts"| MAPT["MAPT"]
    ATG["ATG"] -->|"component_of"| ATG8
    NON_CANONICAL_AUTOPHAGY["NON_CANONICAL_AUTOPHAGY"] -->|"regulates"| ATG8
    ATG4["ATG4"] -->|"regulates"| ATG8
    LAP["LAP"] -->|"activates"| ATG8
    G3BP1["G3BP1"] -->|"interacts"| ATG8
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| ATG8
    GABARAP["GABARAP"] -->|"interacts"| ATG8
    LGALS8 -->|"interacts"| ATG8
    RRAGA["RRAGA"] -->|"interacts"| ATG8
    TAU["TAU"] -->|"interacts"| ATG8
    JUN["JUN"] -->|"interacts"| ATG8
    RRAGB["RRAGB"] -->|"interacts"| ATG8

Outgoing (160)

Target	Relation	Type	Str
LC3	interacts_with	gene	1.00
Autophagy	associated_with	process	0.95
Phosphatidylethanolamine	binds	compound	0.95
Phosphatidylserine	binds	compound	0.95
Casm	involved_in	process	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagy	interacts_with	pathway	0.90
AUTOPHAGY	associated_with	gene	0.80
Als	associated_with	disease	0.75
Cancer	interacts_with	disease	0.75
Parkinson	activates	disease	0.75
Als	regulates	disease	0.75
PE	interacts_with	protein	0.72
PS	interacts_with	protein	0.72
Autophagy	activates	pathway	0.70
Lysosomal Degradation	interacts_with	pathway	0.70
CANCER	interacts_with	gene	0.70
LC3	associated_with	gene	0.70
ALS	interacts_with	disease	0.65
Infection	regulates	disease	0.65
Bacterial Infection	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Infection	expressed_in	disease	0.65
Inflammation	implicated_in	disease	0.65
Breast Cancer	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Infection	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Infection	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	activates	disease	0.65
ALS	activates	disease	0.65
Ms	regulates	disease	0.65
Ataxia	regulates	disease	0.65
Tumor	regulates	disease	0.65
Aging	implicated_in	disease	0.65
Mitophagy	implicated_in	pathway	0.60
Apoptosis	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
MTORC1	inhibits	gene	0.60
STING	activates	gene	0.60
ATG16L1	activates	gene	0.60
TFEB	activates	gene	0.60
CGAS-STING	activates	gene	0.60
MITF	activates	gene	0.60

Incoming (112)

Source	Relation	Type	Str
Non-canonical Autophagy	involved_in	pathway	0.95
Casm	involved_in	process	0.95
RAVZ	cleaves	protein	0.90
ATG4B	associated_with	gene	0.90
ATG	component_of	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
NON_CANONICAL_AUTOPHAGY	regulates	pathway	0.72
PARKINSON	activates	gene	0.70
ATG	interacts_with	gene	0.70
LAP	activates	pathway	0.64
ATG4	regulates	protein	0.64
LYSOSOME	interacts_with	gene	0.60
FMR1	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NFKB	implicated_in	gene	0.60
MAVS	activates	gene	0.60
SQSTM1	implicated_in	gene	0.60
IKBKE	activates	gene	0.60
SQSTM1	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AND	expressed_in	gene	0.60
LC3	activates	gene	0.60
STING	activates	gene	0.60
ATG5	associated_with	gene	0.60
G3BP1	interacts_with	gene	0.60
EIF2A	associated_with	gene	0.60
GABARAP	interacts_with	gene	0.60
LGALS8	interacts_with	gene	0.60
RRAGA	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
JUN	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
ATG14L	interacts_with	gene	0.60
VAMP8	interacts_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
TRPML1	activates	gene	0.60
ATG16L1	activates	gene	0.60
SNAP29	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
NBR1	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
PINK1	activates	gene	0.60
MITOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG8 in their description or question text

No additional research found