gene

NDP52

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDP52: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1123Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

NDP52 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 559 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NDP52
Chromosome	21q22.12.
Protein Type	Gene
Function	Mitophagy: NDP52 recognizes ubiquitinated damaged mitochondria and recruits LC3-positive autophagosomes through its LIR domain
Primary Expression	various tissues with particularly high expression in immune cells and neurons
Amino Acids	452 aa
Exons	11
Pathways	Adaptive Immunity, Autophagy, Complement, Immune Response, Innate Immunity
GeneCards	NDP52
Human Protein Atlas	NDP52
Associated Diseases	AD, ALI, Als, Alzheimer, AMI
Known Drugs/Compounds	dimethyl fumarate, EGCG, rapamycin
Interactions	ABCD3, ABP, ACAT1, ACTB, Actin, AIFM1
KG Connections	1123 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NDP52 Gene

gene · 825 words

→

NDP52 Protein

protein · 776 words

→

Pathway Diagram

graph TD
    NDP52["NDP52"] -->|"recruits"| ULK1["ULK1"]
    NDP52["NDP52"] -->|"activates"| ULK1_1["ULK1"]
    NDP52["NDP52"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    NDP52["NDP52"] -->|"interacts"| Dementia["Dementia"]
    NDP52["NDP52"] -->|"interacts"| Als["Als"]
    NDP52["NDP52"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    PINK1["PINK1"] -->|"recruits"| NDP52["NDP52"]
    TBK1["TBK1"] -->|"facilitates"| NDP52["NDP52"]
    ACTB["ACTB"] -->|"interacts"| NDP52["NDP52"]
    OPTN["OPTN"] -->|"interacts"| NDP52["NDP52"]
    style NDP52 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (685)

Target	Relation	Type	Str
Als	interacts_with	disease	0.95
Als	regulates	disease	0.95
ubiquitin-proteasome	participates_in	pathway	0.90
AUTOPHAGY	regulates	gene	0.90
Mitophagy	mediates	process	0.90
selective autophagy	participates_in	pathway	0.90
Autophagy	activates	pathway	0.90
Mitophagy	regulates	pathway	0.90
OPTN	activates	gene	0.90
UBIQUITIN	interacts_with	gene	0.90
P62	activates	gene	0.90
UBIQUITIN	activates	gene	0.90
Autophagy	interacts_with	pathway	0.90
FIP200	associated_with	protein	0.85
Damaged Organelles	targets	phenotype	0.85
Damaged Organelle Clearance	involved_in	process	0.85
Intracellular Pathogen Clearance	involved_in	process	0.85
PINK1/Parkin signaling pathway	interacts_with	pathway	0.85
Selective Autophagy	involved_in	process	0.85
FIP200	interacts_with	protein	0.84
neural stem cells	activates	cell_type	0.80
LC3B	interacts_with	protein	0.80
ULK1	regulates	gene	0.80
STING	regulates	protein	0.80
nucleocapsid protein	interacts_with	protein	0.80
OPTN	interacts_with	gene	0.80
MITOCHONDRIA	regulates	gene	0.80
P62	interacts_with	gene	0.80
Autophagy	associated_with	pathway	0.80
Infection	regulates	disease	0.75
Cancer	regulates	disease	0.75
MITOPHAGY	activates	pathway	0.74
ULK1	activates	protein	0.72
ULK1	associated_with	protein	0.72
ULK1	interacts_with	gene	0.70
Mitophagy	activates	pathway	0.70
OPTN	associated_with	gene	0.70
RB1	regulates	gene	0.70
TAX1BP1	interacts_with	gene	0.70
TAX1BP1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
Mtor	activates	pathway	0.70
NBR1	activates	gene	0.70
PARKIN	regulates	gene	0.70
TBK1	regulates	gene	0.70
CGAS	regulates	gene	0.70
Mitophagy	interacts_with	pathway	0.70
NLR	regulates	gene	0.70
neural stem cells	regulates	cell_type	0.70
autophagy	regulates	process	0.70

Incoming (438)

Source	Relation	Type	Str
BEX2	interacts_with	protein	0.90
NAP1	promotes	protein	0.90
AUTOPHAGY	interacts_with	gene	0.90
AUTOPHAGY	activates	gene	0.90
TBK1	associated_with	protein	0.85
ATG	regulates	gene	0.80
NBR1	regulates	gene	0.80
BECN1	regulates	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
PINK1	recruits	protein	0.72
G3BP1	regulates	gene	0.70
EGCG	activates	drug	0.70
ALS	regulates	gene	0.70
PINK1	interacts_with	gene	0.70
MITOPHAGY	activates	gene	0.70
MAP1LC3	activates	gene	0.70
ATG	activates	gene	0.70
MAP1LC3	regulates	gene	0.70
AMPK	regulates	gene	0.70
MITOPHAGY	regulates	gene	0.70
FIP200	regulates	gene	0.70
GFP	regulates	gene	0.70
PINK1	activates	gene	0.70
PTEN	interacts_with	gene	0.70
CALCOCO2	encodes	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
MITOCHONDRIA	therapeutic_target	gene	0.60
ALZHEIMER	protects_against	gene	0.60
PTEN-INDUCED PUTATIVE KINASE 1	interacts_with	gene	0.60
AND	therapeutic_target	gene	0.60
COX2	activates	gene	0.60
FIP200	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
HNRNPA1	activates	gene	0.60
PARKIN	regulates	gene	0.60
P62	regulates	gene	0.60
OPTN	regulates	gene	0.60
PINK1	regulates	gene	0.60
AKT	activates	gene	0.60
DRP1	activates	entity	0.60
PERK	interacts_with	gene	0.60
SESN2	interacts_with	gene	0.60
FUNDC1	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
RTN3	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
UBIQUITIN	degrades	gene	0.60
EIF2S1	activates	entity	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle	0.772	neurodegeneration	How do different organelle-specific auto

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDP52 in their description or question text

No additional research found