protein

MIRO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIRO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1117Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

10Experiments

1Debates

Summary

Miro1 (RHOT1) is a mitochondrial Rho GTPase that regulates mitochondrial transport, calcium homeostasis, and quality control in neurons, with critical roles in Alzheimer's disease, Parkinson's disease, and ALS pathogenesis

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🔬 Protein Info

Gene Symbol	MIRO1
Aliases	RHOT1
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	MIRO1-targeting drugs modulate GTPase activity to enhance mitochondrial transport along axons and improve mitochondrial quality control through selective autophagy. By regulating MIRO1's interactio...
Mechanism of Action	MIRO1-targeting drugs modulate GTPase activity to enhance mitochondrial transport along axons and improve mitochondrial quality control through selective autophagy. By regulating MIRO1's interaction with kinesin motor proteins and PINK1-mediated mitophagy, these compounds restore energy homeostasis and reduce neuronal stress in neurodegenerative diseases.
Druggability	Low (0.29)
Clinical Stage	Phase II
Molecular Weight	71 kDa
Pathways	Mitochondrial Function, Mitochondrial dynamics / bioenergetics, Therapeutic Target Development
UniProt ID	Q8IXI2
GeneCards	MIRO1
Human Protein Atlas	MIRO1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Miro-inhibitor-001, GTPASE-mod-42, Mitochondrial transport enhancer XR-789, MIRO1-stabilizing compound MRS-2
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Mitochondrial Transfer Pathway Enhancement
KG Connections	1099 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MIRO1 — AlphaFold Q8IXI2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

RHOT1 Protein - MIRO1 - Mitochondrial Rho GTPase 1

protein · 1223 words

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Pathway Diagram

graph TD
    MIRO1["MIRO1"] -->|"interacts with"| Dementia["Dementia"]
    MIRO1["MIRO1"] -->|"interacts with"| Cardiovascular["Cardiovascular"]
    MIRO1["MIRO1"] -->|"interacts with"| Als["Als"]
    MIRO1["MIRO1"] -->|"interacts with"| Alzheimer["Alzheimer"]
    MIRO1["MIRO1"] -->|"interacts with"| Parkinson["Parkinson"]
    MIRO1["MIRO1"] -->|"interacts with"| Ms["Ms"]
    h_969bd8e0["h-969bd8e0"] -->|"targets"| MIRO1["MIRO1"]
    CAT["CAT"] -->|"interacts with"| MIRO1["MIRO1"]
    OPTN["OPTN"] -->|"interacts with"| MIRO1["MIRO1"]
    DNM1L["DNM1L"] -->|"interacts with"| MIRO1["MIRO1"]
    style MIRO1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (659)

Target	Relation	Type	Str
ALS	downregulated_in	disease	1.00
mitochondrial transfer	mediates	process	0.95
Mitochondrial Transfer	involved_in	process	0.95
Mitochondrial-Derived Vesicle Biogenesis	activates	process	0.95
mitochondrial-derived vesicle biogenesis	drives	process	0.95
Neurological Disorders	targets	disease	0.95
Mitochondrial-Derived Vesicle Biogenesis	promotes	process	0.95
Mitochondrial Transport	regulates	pathway	0.95
Mitochondrial Transport	involved_in	process	0.95
Mitochondrial Transfer	regulates	process	0.95
MITOCHONDRIAL TRANSFER	regulates	entity	0.95
Parkinson'S Disease	associated_with	disease	0.95
Cerebral Ischemia-Reperfusion Injury	protects_against	disease	0.95
Intercellular Mitochondrial Transport	regulates	process	0.95
Neurological Disorders	therapeutic_target	disease	0.90
Mitochondrial Rho Gtpase	encodes	protein	0.90
Mitochondrial motility	regulates	process	0.90
Mesenchymal Stem Cell	expressed_in	cell_type	0.90
Calcium Sequestration	involved_in	process	0.90
MITOCHONDRIAL QUALITY CONTROL	involved_in	entity	0.90
OSTEOCLAST	regulates	entity	0.90
Therapeutic Target Development	involved_in	process	0.90
mitochondrial function	modulates	process	0.90
ASTROCYTES	expressed_in	cell_type	0.90
TRAK1	binds	protein	0.90
Neurological Disorders	associated_with	disease	0.90
membrane protrusion formation	mediates	process	0.90
Neurological Disorders	associated_with	disease	0.90
Mitochondrial Motility	mediates	process	0.90
EPITHELIAL CELL INJURY	protects_against	entity	0.90
epithelial cell mitochondrial dysfunction	regulates	phenotype	0.90
MESENCHYMAL STEM CELL	expressed_in	entity	0.90
epithelial injury rescue	promotes	process	0.90
Parkinson'S Disease	associated_with	disease	0.90
Mitochondrial Function	involved_in	process	0.85
Neurodegeneration	involved_in	process	0.85
Mitochondrial Function	regulates	process	0.85
Neurodegeneration	contributes_to	phenotype	0.85
Mitochondrial Transfer	mediates	mechanism	0.85
bone resorption	suppresses	process	0.85
Mitochondrial Dynamics	regulates	process	0.85
Parkinson disease	associated_with	disease	0.85
neuronal viability	promotes	phenotype	0.85
Epithelial Cell Injury	inhibits	process	0.85
MITOCHONDRIAL DYSFUNCTION	protects_against	entity	0.85
mitochondrial transfer	associated_with	process	0.85
FERROPTOSIS	involved_in	entity	0.85
asthma	therapeutic_target	disease	0.85
airway hyperresponsiveness	suppresses	phenotype	0.85
airway remodeling	suppresses	phenotype	0.85

Incoming (458)

Source	Relation	Type	Str
RHOT1	encodes	gene	1.00
RHOT1	encodes	gene	0.95
SNCA	upregulates	protein	0.95
h-969bd8e0	targets_gene	hypothesis	0.90
GJ-PD	upregulates	drug	0.90
PARKIN	ubiquitinates	gene	0.80
GJ-PD herbal pair	upregulates	drug	0.80
h-969bd8e0	targets	hypothesis	0.80
electroacupuncture	upregulates	drug	0.80
Geum japonicum Thunb. var. chinense-Potentilla decorata H. Andres	upregulates	drug	0.80
PRKN	targets	protein	0.80
CD38	interacts_with	gene	0.75
PINK1	phosphorylates	protein	0.75
HIF	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
BIM	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
DRP1	activates	entity	0.60
PARKINSON	associated_with	gene	0.60
AGING	regulates	gene	0.60
FERROPTOSIS	activates	gene	0.60
PARKINSON	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
FTLD	activates	gene	0.60
ASTROCYTES	transports	gene	0.60
ASTROCYTE	transports	gene	0.60
ASTROCYTES	regulates	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
ALS	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
MITOCHONDRIA	protects_against	gene	0.60
ATP	protects_against	gene	0.60
DYNEIN	interacts_with	gene	0.60
TNF	inhibits	gene	0.60
AND	inhibits	gene	0.60
NF-ΚB	activates	gene	0.60
MITOCHONDRIA	transports	gene	0.60
BRAIN INJURY	expressed_in	gene	0.60
PARKINSON	causes	gene	0.60
BCL-2	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
MOTOR NEURONS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
PARKIN	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial Transfer Pathway Enhancement	0.695	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso	validation	Parkinson's Disease	0.400	0.50	human	proposed	$3,000,000
Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$160,000
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment Design	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Exercise-BDNF-Mitophagy Biomarker Study in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Cytochrome Therapeutics	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886]	Yao RQ, Ren C, Xia ZF, Yao YM	Autophagy	2021	2
Miro1: A potential target for treating neurological disorders. [PMID:40403957]	Zeng L, Yang J, Zhang C, Zhu J, Zhong S,	Neuroscience	2025	1
Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020]	Ding P, Gao C, Zhou J, Mei J, Li G, Liu	Nat Commun	2024	1
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote qualit [PMID:34873283]	König T, Nolte H, Aaltonen MJ, Tatsuta T	Nat Cell Biol	2021	1
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal ste [PMID:24431222]	Ahmad T, Mukherjee S, Pattnaik B, Kumar	EMBO J	2014	1
L-Carnitine and Acetyl-L-Carnitine in Drug Poisonings: A Systematic Review of Cl [PMID:41692009]	["Rezaee H", "Abbasgholizadeh F"]	Journal of applied toxicology	2026	0
Mechanistic Insights into the Cardioprotective Effects of Mesenchymal Stem Cell- [PMID:41900832]	["Othman Basri N", "Che Roos N", "Aminud	Pharmaceutics	2026	0
Miro1 in Parkinson's Disease: A Key Regulator of Mitochondrial Homeostasis and N [PMID:41792389]	Singh G, Kaur S, Aran KR	Neuromolecular medicine	2026	0
Boronophenylalanine-Mediated Boron Neutron Capture Therapy Confers Selective Kil [PMID:41817167]	["Zhang L", "Quan R", "Huang H", "Wu M",	Cancer biotherapy & radiopharm	2026	0
Miro1 Mediates the Neuroprotective Effects of Electroacupuncture Against Cerebra [PMID:41914243]	["Lian H", "Sun Y", "Zhang M", "Gao X",	Journal of integrative neurosc	2026	0
Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates C [PMID:41678910]	["Sun F", "She R", "Yang T", "Chen B", "	Phytomedicine : international	2026	0
Selenium nanoparticles activate selenoproteins to mitigate septic lung injury th [PMID:40114196]	["Gu W", "Zhao F", "Huang W", "Zhu M", "	Journal of nanobiotechnology	2025	0
Targeting Mitochondrial Dynamics via EV Delivery in Regenerative Cardiology: Mec [PMID:41227383]	["Shahannaz D", "Sugiura T", "Ferrell B"	Cells	2025	0
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminerg [PMID:39913247]	Chemla A, Arena G, Sacripanti G, Barmpa	Brain : a journal of neurology	2025	0
Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria [PMID:41145425]	["Wang Y", "Yu H", "Yi Z", "Qi L", "Yang	Nature communications	2025	0
Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity [PMID:41116174]	["Jiang H", "Liu L", "He S", "Qu S", "Ya	Journal of biomedical science	2025	0
Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: t [PMID:40598228]	["Guo Y", "Fu T", "Cheng Y", "Li Y", "Zh	Cell communication and signali	2025	0
The tumour microenvironment, treatment resistance and recurrence in glioblastoma [PMID:38844944]	["White J", "White M", "Wickremesekera A	Journal of translational medic	2024	0
The Emerging Role of RHOT1/Miro1 in the Pathogenesis of Parkinson's Disease. [PMID:33041957]	Grossmann D, Berenguer-Escuder C, Chemla	Frontiers in neurology	2020	0
Precision Neurology for Parkinson's Disease: Coupling Miro1-Based Diagnosis With [PMID:32710675]	["Bharat V", "Wang X"]	Movement disorders : official	2020	0

Debates (1)

Multi-agent debates referencing this entity

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10