gene

RTN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RTN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

526Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RTN3 (Reticulon 3): ER morphogenesis protein involved in autophagy, APP processing, and neurodegenerative diseases including Alzheimer's and Huntington's disease

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🧬 Gene Info

Gene Symbol	RTN3
Full Name	Reticulon 3
Aliases	Reticulon-3
Chromosome	6p22.3
Function	is a member of the reticulon family of membrane proteins primarily localized to the endoplasmic reticulum (ER).
Subcellular Localization	the endoplasmic reticulum (ER). RTN3 plays critical roles in ER morphology, autophagosome formation, and protein quality
Amino Acids	200 aa
Pathways	mTOR, mtor
UniProt ID	Q9Y3I0
NCBI Gene ID	10318
Ensembl ID	ENSG00000148681
OMIM	604258
GeneCards	RTN3
Human Protein Atlas	RTN3
Tubular network formation	RTN3 promotes the formation and maintenance of ER tubules
Associated Diseases	AD, ALI, Als, Alzheimer, dementia
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, Actin, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections	526 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RTN3 — AlphaFold Q9Y3I0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RTN3 Gene

gene · 702 words

→

RTN3 Protein (Reticulon-3)

protein · 856 words

→

Pathway Diagram

graph TD
    RTN3["RTN3"] -->|"Interacts With"| Dementia["Dementia"]
    RTN3["RTN3"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    RTN3["RTN3"] -->|"Interacts With"| Als["Als"]
    RTN3["RTN3"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    RTN3["RTN3"] -->|"Interacts With"| Parkinson["Parkinson"]
    RTN3["RTN3"] -->|"Interacts With"| Ms["Ms"]
    RTN3["RTN3"] -->|"Interacts With"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    RTN3["RTN3"] -->|"Interacts With"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    CAT["CAT"] -->|"Interacts With"| RTN3["RTN3"]
    OPTN["OPTN"] -->|"Interacts With"| RTN3["RTN3"]
    DNM1L["DNM1L"] -->|"Interacts With"| RTN3["RTN3"]
    CANX["CANX"] -->|"Interacts With"| RTN3["RTN3"]
    LGALS3["LGALS3"] -->|"Interacts With"| RTN3["RTN3"]
    style RTN3 fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Amyotrophic_Lateral_Sclerosis fill:#b71c1c,color:#e0e0e0
    style Frontotemporal_Dementia fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (230)

Target	Relation	Type	Str
ubiquitin-proteasome	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
ALS	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
endothelial cells	expressed_in	cell_type	0.60
Lysosomal Degradation	associated_with	pathway	0.60
Mitophagy	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
PRESENILIN	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NUCLEOPHAGY	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MFN1	interacts_with	gene	0.60
PARL	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
FMR1	interacts_with	gene	0.60

Incoming (296)

Source	Relation	Type	Str
RB1	activates	gene	0.70
ATG	activates	gene	0.70
ATP	activates	gene	0.60
BIM	activates	gene	0.60
DNA	activates	gene	0.60
HIF	activates	gene	0.60
HIF1	activates	gene	0.60
LC3B	activates	gene	0.60
NIX	activates	gene	0.60
NLR	activates	gene	0.60
PGAM5	activates	gene	0.60
RETREG1	activates	gene	0.60
RIP3	activates	gene	0.60
ROS	activates	gene	0.60
GABARAP	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
RB1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60
RAB2A	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
PARL	interacts_with	gene	0.60
PERK	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
EIF2AK3	activates	entity	0.60
EPAS1	activates	entity	0.60
PHB2	interacts_with	gene	0.60
LYSOSOME	associated_with	gene	0.60
CATALASE	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
RIP3	interacts_with	gene	0.60
SESTRIN2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
BCL2	activates	entity	0.60
BCL2L11	activates	entity	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
ATM	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RTN3 in their description or question text

No additional research found