protein

ATF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

563Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

ATF4 is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 313 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	ATF4
Full Name	Activating Transcription Factor 4
Chromosome	22q13.1
Protein Type	Transcription Factor
Function	Amino acid metabolism: Upregulates genes involved in amino acid transport and synthesis
Molecular Weight	38.6 kDa
Pathways	Apoptosis, Autophagy, Epigenetic, Er Stress, Ferroptosis
UniProt ID	[P18848](https://www.uniprot.org/uniprot/P18848)
GeneCards	ATF4
Human Protein Atlas	ATF4
Associated Diseases	Aging, Atherosclerosis, cancer, Glioblastoma, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACSL4, Actin, AGING, AKT, AMPK, AMYLOID
SciDEX Hypotheses	ATF4-DDIT3 stress signaling indirectly represses M
KG Connections	563 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATF4["ATF4"] -->|"regulates"| mitophagy["mitophagy"]
    ATF4["ATF4"] -->|"therapeutic target"| Ms["Ms"]
    ATF4["ATF4"] -->|"therapeutic target"| Als["Als"]
    ATF4["ATF4"] -->|"interacts"| Cancer["Cancer"]
    ATF4["ATF4"] -->|"interacts"| Aging["Aging"]
    ATF4["ATF4"] -->|"interacts"| Ms_1["Ms"]
    CXCL2["CXCL2"] -->|"therapeutic target"| ATF4["ATF4"]
    IL6["IL6"] -->|"therapeutic target"| ATF4["ATF4"]
    GABARAP["GABARAP"] -->|"associated"| ATF4["ATF4"]
    RANK["RANK"] -->|"regulates"| ATF4["ATF4"]
    style ATF4 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (353)

Target	Relation	Type	Str
Integrated Stress Response	regulates	pathway	0.88
Apoptosis	upregulates	process	0.88
Integrated Stress Response	mediates	pathway	0.85
Apoptosis	associated_with	process	0.85
Cell Death	promotes	phenotype	0.85
INTEGRATED STRESS RESPONSE	mediates	entity	0.85
integrated stress response	promotes	pathway	0.85
Als	activates	disease	0.85
Er Stress	activates	pathway	0.80
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
Tumor	activates	disease	0.75
Als	regulates	disease	0.75
DDIT3	activates	gene	0.70
Mtor	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
mitophagy	regulates	process	0.70
ACSL4	activates	protein	0.70
apoptosis pathway	participates_in	pathway	0.70
Glaucoma	regulates	disease	0.65
Leukemia	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Glioblastoma	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Senescence	activates	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Ischemia	protects_against	disease	0.65
Fibrosis	activates	disease	0.65
Tumor	associated_with	disease	0.65
Aging	regulates	disease	0.65
Anxiety	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Atherosclerosis	associated_with	disease	0.65

Incoming (210)

Source	Relation	Type	Str
p38 MAPK	phosphorylates	protein	0.90
Identified Compounds	upregulates	compound	0.90
PERK	upregulates	protein	0.85
EFTUD2	regulates	gene	0.85
DTG	upregulates	drug	0.85
ATG2A-G433A	upregulates	variant	0.85
DDIT3	upregulates	gene	0.80
APOPTOSIS	activates	gene	0.70
APOE4	inhibits	protein	0.70
MITOPHAGY	activates	gene	0.70
PERK	activates	gene	0.70
GPX4	biomarker_for	gene	0.60
RELA	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
SP1	expressed_in	gene	0.60
IRF7	expressed_in	gene	0.60
PPARGC1A	activates	gene	0.60
TAZ	associated_with	gene	0.60
SATB2	associated_with	gene	0.60
PIEZO1	regulates	gene	0.60
PUMA	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
AKT	activates	gene	0.60
NOXA	activates	gene	0.60
MDM2	activates	gene	0.60
CDK4	activates	gene	0.60
SEL1L	activates	gene	0.60
TIMM17B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ERN1	activates	gene	0.60
IL12B	activates	gene	0.60
HSPA5	activates	gene	0.60
CXCL2	activates	gene	0.60
IL23A	activates	gene	0.60
OCLN	activates	gene	0.60
IL6	activates	gene	0.60
CLDN5	activates	gene	0.60
DDIT3	activates	gene	0.60
IRE1	activates	gene	0.60
CXCL1	activates	gene	0.60
EIF2A	associated_with	gene	0.60
RRAGA	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
RRAGB	interacts_with	gene	0.60
FMR1	associated_with	gene	0.60
TIA1	associated_with	gene	0.60
FAM134B	activates	gene	0.60
VEGF	inhibits	gene	0.60
OCLN	therapeutic_target	gene	0.60
IL23A	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ATF4-DDIT3 stress signaling indirectly represses MAPT transc	0.624	neurodegeneration	Which specific transcription factors med

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While ACSL4-driven ferroptosis was strongly supported, the molecular triggers th

closed · Rounds: 4 · Score: 0.80 · 2026-04-16

Related Research

Hypotheses and analyses mentioning ATF4 in their description or question text

No additional research found