gene

CHOP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

907Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CHOP is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ALI, ALS. Connected to 421 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHOP
Chromosome	12q13.12
Protein Type	Protein
Function	is a leucine zipper transcription factor that functions as a critical regulator of cellular stress responses, particularly during endoplasmic reticulum (ER) stress and the unfolded protein response...
Pathways	Apoptosis, Epigenetic, Er Stress, Ferroptosis, Glycolysis
UniProt ID	Search UniProt
GeneCards	CHOP
Human Protein Atlas	CHOP
Associated Diseases	AD, ALI, Als, Alzheimer, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	907 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHOP — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHOP["CHOP"] -->|"Interacts With"| Dementia["Dementia"]
    CHOP["CHOP"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    CHOP["CHOP"] -->|"Interacts With"| Als["Als"]
    CHOP["CHOP"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    CHOP["CHOP"] -->|"Interacts With"| Parkinson["Parkinson"]
    CHOP["CHOP"] -->|"Interacts With"| Ms["Ms"]
    CHOP["CHOP"] -->|"Associated With"| Lymphoma["Lymphoma"]
    CHOP["CHOP"] -->|"Associated With"| Inflammation["Inflammation"]
    CAT["CAT"] -->|"Interacts With"| CHOP["CHOP"]
    OPTN["OPTN"] -->|"Interacts With"| CHOP["CHOP"]
    DNM1L["DNM1L"] -->|"Interacts With"| CHOP["CHOP"]
    CANX["CANX"] -->|"Interacts With"| CHOP["CHOP"]
    LGALS3["LGALS3"] -->|"Interacts With"| CHOP["CHOP"]
    style CHOP fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Lymphoma fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (557)

Target	Relation	Type	Str
Als	activates	disease	0.85
Er Stress	activates	pathway	0.80
Neurodegeneration	activates	disease	0.75
Inflammation	activates	disease	0.75
Cancer	inhibits	disease	0.75
Apoptosis	inhibits	pathway	0.70
neural stem cells	activates	cell_type	0.70
Unfolded Protein Response	activates	pathway	0.70
Parkinson	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	activates	disease	0.65
Lymphoma	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ftd	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Cirrhosis	inhibits	disease	0.65
Ovarian Cancer	inhibits	disease	0.65
Glaucoma	regulates	disease	0.65
Hepatitis	inhibits	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Autoimmune	activates	disease	0.65
Als	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Tumor	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Lymphoma	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Senescence	activates	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
unfolded protein response	participates_in	pathway	0.65

Incoming (350)

Source	Relation	Type	Str
ATG2A-G433A	upregulates	variant	0.85
CANCER	inhibits	gene	0.70
NEURODEGENERATION	activates	gene	0.70
BIP	activates	gene	0.70
APOE4	activates	gene	0.65
SNCA	interacts_with	gene	0.60
FAM134B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
EPAS1	interacts_with	gene	0.60
MIRO1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
EIF2S1	interacts_with	gene	0.60
RIPK3	interacts_with	gene	0.60
ATF3	regulates	gene	0.60
ASC	activates	gene	0.60
NLRP3	activates	gene	0.60
DRP1	activates	gene	0.60
DRP1	interacts_with	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
FMR1	interacts_with	gene	0.60
LC3B	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
PROTEASOME INHIBITION	inhibits	gene	0.60
JAK	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PROINFLAMMATORY CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
MIR-9-5P	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AMYLOID-Β PLAQUES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
MYOD	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
ASNS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHOP in their description or question text

No additional research found