gene

CHOP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

905Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CHOP is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ALI, ALS. Connected to 421 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHOP
Chromosome	12q13.12
Protein Type	Protein
Function	is a leucine zipper transcription factor that functions as a critical regulator of cellular stress responses, particularly during endoplasmic reticulum (ER) stress and the unfolded protein response...
Pathways	Apoptosis, Epigenetic, Er Stress, Ferroptosis, Glycolysis
UniProt ID	Search UniProt
GeneCards	CHOP
Human Protein Atlas	CHOP
Associated Diseases	AD, ALI, Als, Alzheimer, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	904 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHOP — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHOP["CHOP"] -->|"Interacts With"| Dementia["Dementia"]
    CHOP["CHOP"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    CHOP["CHOP"] -->|"Interacts With"| Als["Als"]
    CHOP["CHOP"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    CHOP["CHOP"] -->|"Interacts With"| Parkinson["Parkinson"]
    CHOP["CHOP"] -->|"Interacts With"| Ms["Ms"]
    CHOP["CHOP"] -->|"Associated With"| Lymphoma["Lymphoma"]
    CHOP["CHOP"] -->|"Associated With"| Inflammation["Inflammation"]
    CAT["CAT"] -->|"Interacts With"| CHOP["CHOP"]
    OPTN["OPTN"] -->|"Interacts With"| CHOP["CHOP"]
    DNM1L["DNM1L"] -->|"Interacts With"| CHOP["CHOP"]
    CANX["CANX"] -->|"Interacts With"| CHOP["CHOP"]
    LGALS3["LGALS3"] -->|"Interacts With"| CHOP["CHOP"]
    style CHOP fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Lymphoma fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (555)

Target	Relation	Type	Str
CHOP	encodes	protein	0.00
Als	activates	disease	0.85
Er Stress	activates	pathway	0.80
Inflammation	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Cancer	inhibits	disease	0.75
Apoptosis	inhibits	pathway	0.70
Unfolded Protein Response	activates	pathway	0.70
neural stem cells	activates	cell_type	0.70
Oligodendrocyte death	causes	mechanism	0.70
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Glaucoma	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	expressed_in	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Senescence	activates	disease	0.65
Als	expressed_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Autoimmune	activates	disease	0.65
Ms	inhibits	disease	0.65
Neuropathy	associated_with	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Lymphoma	expressed_in	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Carcinoma	regulates	disease	0.65
Als	regulates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cirrhosis	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Ms	regulates	disease	0.65
Tumor	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ovarian Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65

Incoming (350)

Source	Relation	Type	Str
CHOP	encodes	gene	0.00
ATG2A-G433A	upregulates	variant	0.85
BIP	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
CANCER	inhibits	gene	0.70
APOE4	activates	gene	0.65
SGK1	therapeutic_target	gene	0.60
MYD88	therapeutic_target	gene	0.60
SOCS1	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
NOTCH1	therapeutic_target	gene	0.60
ATF3	contributes_to	gene	0.60
CAT	associated_with	gene	0.60
MYC	associated_with	gene	0.60
BNIP3	activates	gene	0.60
PARKIN	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MFN2	activates	gene	0.60
ATF3	regulates	gene	0.60
AXON REGENERATION	regulates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MTORC1	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
MIR-9-5P	regulates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
MICROGLIA	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AMYLOID-Β PLAQUES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ASTROCYTES	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
ROS	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
TET2	therapeutic_target	gene	0.60
NOX	associated_with	gene	0.60
BCL-2	associated_with	gene	0.60
P53	associated_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
P53	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2alpha Dephosphorylation Threshold Prevents Pro-Apoptotic	0.445	-	What is the minimum effective dose of tr

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific gene expression signatures in aging mouse white matter predict hum

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate initiated investigation into white matter aging and myelin changes bu

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning CHOP in their description or question text

No additional research found